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WO2008133274A1 - 環式基で置換されたアミノジヒドロチアジン誘導体 - Google Patents

環式基で置換されたアミノジヒドロチアジン誘導体 Download PDF

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Publication number
WO2008133274A1
WO2008133274A1 PCT/JP2008/057847 JP2008057847W WO2008133274A1 WO 2008133274 A1 WO2008133274 A1 WO 2008133274A1 JP 2008057847 W JP2008057847 W JP 2008057847W WO 2008133274 A1 WO2008133274 A1 WO 2008133274A1
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WIPO (PCT)
Prior art keywords
optionally substituted
substituted lower
lower alkyl
cyclic groups
derivatives substituted
Prior art date
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PCT/JP2008/057847
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English (en)
French (fr)
Inventor
Yuusuke Tamura
Shinji Suzuki
Yukio Tada
Shuji Yonezawa
Chiaki Fujikoshi
Sae Matsumoto
Yuuji Kooriyama
Tatsuhiko Ueno
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Shionogi & Co., Ltd.
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Publication date
Priority to US12/596,796 priority Critical patent/US8168630B2/en
Priority to BRPI0811034-4A2A priority patent/BRPI0811034A2/pt
Priority to ES08751985.6T priority patent/ES2476605T3/es
Priority to MX2009011498A priority patent/MX2009011498A/es
Priority to CN200880021335.4A priority patent/CN101687827B/zh
Priority to AU2008245082A priority patent/AU2008245082B8/en
Priority to RU2009143333/04A priority patent/RU2476430C2/ru
Priority to JP2009511888A priority patent/JP5383484B2/ja
Priority to CA002683887A priority patent/CA2683887A1/en
Priority to EP08751985.6A priority patent/EP2147914B1/en
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Publication of WO2008133274A1 publication Critical patent/WO2008133274A1/ja
Priority to US13/417,786 priority patent/US8541408B2/en
Priority to US13/887,745 priority patent/US8884062B2/en

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
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Abstract

アミロイドβタンパク質の産生、分泌または沈着により誘発される疾患の治療剤として有用な式（Ｉ）に示される化合物を提供する。 式（Ｉ）： （式中、環Ａは置換基を有していてもよい炭素環式基または置換基を有していてもよい複素環式基であり、 Ｒ1は置換基を有していてもよい低級アルキル、置換基を有していてもよい低級アルケニルまたは置換基を有していてもよい低級アルキニルであり、 Ｒ２ａおよびＲ２ｂは各々独立して水素、置換基を有していてもよい低級アルキルまたは置換基を有していてもよいアシルであり、 Ｒ３ａ、Ｒ３ｂ、Ｒ３cおよびＲ３dは各々独立して水素、ハロゲン、ヒドロキシ、置換基を有していてもよい低級アルキル等である） で示される化合物もしくはその製薬上許容される塩またはそれらの溶媒和物。
PCT/JP2008/057847 2007-04-24 2008-04-23 環式基で置換されたアミノジヒドロチアジン誘導体 WO2008133274A1 (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CA002683887A CA2683887A1 (en) 2007-04-24 2008-04-23 Aminodihydrothiazine derivatives substituted with a cyclic group having inhibitory activity against production of amyloid beta protein
ES08751985.6T ES2476605T3 (es) 2007-04-24 2008-04-23 Derivados de aminohidrotiazina sustituidos con grupos cíclicos
MX2009011498A MX2009011498A (es) 2007-04-24 2008-04-23 Derivados de aminodihidrotiazina sustituida con un grupo ciclico.
CN200880021335.4A CN101687827B (zh) 2007-04-24 2008-04-23 环状基团取代的氨基二氢噻嗪衍生物
AU2008245082A AU2008245082B8 (en) 2007-04-24 2008-04-23 Aminodihydrothiazine derivatives substituted with a cyclic group
US12/596,796 US8168630B2 (en) 2007-04-24 2008-04-23 Aminodihydrothiazine derivatives substituted with a cyclic group
JP2009511888A JP5383484B2 (ja) 2007-04-24 2008-04-23 環式基で置換されたアミノジヒドロチアジン誘導体
RU2009143333/04A RU2476430C2 (ru) 2007-04-24 2008-04-23 Производные аминодигидротиазина, замещенные циклической группой
EP08751985.6A EP2147914B1 (en) 2007-04-24 2008-04-23 Aminodihydrothiazine derivatives substituted with cyclic groups
BRPI0811034-4A2A BRPI0811034A2 (pt) 2007-04-24 2008-04-23 Derivados de aminodi-hidrotiazina substituídos com um grupo cíclico e seus usos e composições farmacêuticas
US13/417,786 US8541408B2 (en) 2007-04-24 2012-03-12 Aminodihydrothiazine derivatives substituted with a cyclic group
US13/887,745 US8884062B2 (en) 2007-04-24 2013-05-06 Aminodihydrothiazine derivatives substituted with a cyclic group

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-114288 2007-04-24
JP2007114288 2007-04-24
JP2007-290589 2007-11-08
JP2007290589 2007-11-08

Related Child Applications (2)

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US12/596,796 A-371-Of-International US8168630B2 (en) 2007-04-24 2008-04-23 Aminodihydrothiazine derivatives substituted with a cyclic group
US13/417,786 Division US8541408B2 (en) 2007-04-24 2012-03-12 Aminodihydrothiazine derivatives substituted with a cyclic group

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US (3) US8168630B2 (ja)
EP (2) EP2147914B1 (ja)
JP (2) JP5383484B2 (ja)
KR (1) KR20100017255A (ja)
CN (1) CN101687827B (ja)
AU (1) AU2008245082B8 (ja)
BR (1) BRPI0811034A2 (ja)
CA (1) CA2683887A1 (ja)
ES (1) ES2476605T3 (ja)
MX (1) MX2009011498A (ja)
RU (1) RU2476430C2 (ja)
TW (1) TW200902526A (ja)
WO (1) WO2008133274A1 (ja)

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US8541408B2 (en) 2013-09-24
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