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WO2008000950A3 - Dérivés d'urées de piperidine ou pyrrolidine, leur préparation et leur application en thérapeutique - Google Patents

Dérivés d'urées de piperidine ou pyrrolidine, leur préparation et leur application en thérapeutique Download PDF

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Publication number
WO2008000950A3
WO2008000950A3 PCT/FR2007/001069 FR2007001069W WO2008000950A3 WO 2008000950 A3 WO2008000950 A3 WO 2008000950A3 FR 2007001069 W FR2007001069 W FR 2007001069W WO 2008000950 A3 WO2008000950 A3 WO 2008000950A3
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WO
WIPO (PCT)
Prior art keywords
preparation
ureas
pyrrolidine
piperidine
derivatives
Prior art date
Application number
PCT/FR2007/001069
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English (en)
Other versions
WO2008000950A2 (fr
Inventor
Alain Braun
Stefan Gussregen
Patrick Mougenot
Claudie Namane
Eric Nicolai
Francois Pacquet
Christophe Philippo
Olivier Venier
Olivier Crespin
Cecile Pascal
Michel Aletru
Original Assignee
Sanofi Aventis
Alain Braun
Stefan Gussregen
Patrick Mougenot
Claudie Namane
Eric Nicolai
Francois Pacquet
Christophe Philippo
Olivier Venier
Olivier Crespin
Cecile Pascal
Michel Aletru
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0605786A external-priority patent/FR2902790A1/fr
Application filed by Sanofi Aventis, Alain Braun, Stefan Gussregen, Patrick Mougenot, Claudie Namane, Eric Nicolai, Francois Pacquet, Christophe Philippo, Olivier Venier, Olivier Crespin, Cecile Pascal, Michel Aletru filed Critical Sanofi Aventis
Priority to MX2008016563A priority Critical patent/MX2008016563A/es
Priority to BRPI0713042-2A priority patent/BRPI0713042A2/pt
Priority to JP2009517318A priority patent/JP2009541463A/ja
Priority to EP07803781A priority patent/EP2044057A2/fr
Priority to AU2007264791A priority patent/AU2007264791A1/en
Priority to CA002652852A priority patent/CA2652852A1/fr
Publication of WO2008000950A2 publication Critical patent/WO2008000950A2/fr
Publication of WO2008000950A3 publication Critical patent/WO2008000950A3/fr
Priority to IL195820A priority patent/IL195820A0/en
Priority to US12/337,967 priority patent/US7947834B2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'invention concerne des composés répondant à la formule (I): dans laquelle R1a, R1b, R 1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b, R4, n, j, j, o, p, q, r et X sont tels que définis dans la description et leur utilisation comme modulateurs de la 11 β- hydroxystéroïde déhydrogénase de type 1 pour le traitement du syndrome métabolique ou du diabète de type 2.
PCT/FR2007/001069 2006-06-27 2007-06-26 Dérivés d'urées de piperidine ou pyrrolidine, leur préparation et leur application en thérapeutique WO2008000950A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MX2008016563A MX2008016563A (es) 2006-06-27 2007-06-26 Derivados de ureas de piperidina o pirrolidina, su preparación y su aplicación en terapeutica.
BRPI0713042-2A BRPI0713042A2 (pt) 2006-06-27 2007-06-26 derivados de urÉias de piperidina ou pirrolidina, o respectivo preparo e a respectiva aplicaÇço em terapÊutica
JP2009517318A JP2009541463A (ja) 2006-06-27 2007-06-26 ピペリジンまたはピロリジンの尿素誘導体、これらの調製およびこれらの治療的使用
EP07803781A EP2044057A2 (fr) 2006-06-27 2007-06-26 Dérivés d'urées de piperidine ou pyrrolidine, leur préparation et leur application en thérapeutique
AU2007264791A AU2007264791A1 (en) 2006-06-27 2007-06-26 Derivatives of ureas of piperidine or pyrrolidine, their preparation and their therapeutical use
CA002652852A CA2652852A1 (fr) 2006-06-27 2007-06-26 Derives d'urees de piperidine ou pyrrolidine, leur preparation et leur application en therapeutique
IL195820A IL195820A0 (en) 2006-06-27 2008-12-09 Derivatives of ureas of piperidine or pyrrolidine, their preparation and their therapeutical use
US12/337,967 US7947834B2 (en) 2006-06-27 2008-12-18 Substituted quinoxalines, their preparation and their therapeutical use as 11βHSD1 modulators

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0605786A FR2902790A1 (fr) 2006-06-27 2006-06-27 Derives d'urees de piperidine ou pyrrolidine,leur preparation et leur application en therapeutique
FR0605786 2006-06-27
FR0611239 2006-12-22
FR0611239 2006-12-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/337,967 Continuation US7947834B2 (en) 2006-06-27 2008-12-18 Substituted quinoxalines, their preparation and their therapeutical use as 11βHSD1 modulators

Publications (2)

Publication Number Publication Date
WO2008000950A2 WO2008000950A2 (fr) 2008-01-03
WO2008000950A3 true WO2008000950A3 (fr) 2008-02-14

Family

ID=38692075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/001069 WO2008000950A2 (fr) 2006-06-27 2007-06-26 Dérivés d'urées de piperidine ou pyrrolidine, leur préparation et leur application en thérapeutique

Country Status (16)

Country Link
US (1) US7947834B2 (fr)
EP (1) EP2044057A2 (fr)
JP (1) JP2009541463A (fr)
KR (1) KR20090021192A (fr)
AR (1) AR061643A1 (fr)
AU (1) AU2007264791A1 (fr)
BR (1) BRPI0713042A2 (fr)
CA (1) CA2652852A1 (fr)
CL (1) CL2007001886A1 (fr)
IL (1) IL195820A0 (fr)
MX (1) MX2008016563A (fr)
PE (1) PE20080212A1 (fr)
RU (1) RU2009102527A (fr)
TW (1) TW200811158A (fr)
UY (1) UY30448A1 (fr)
WO (1) WO2008000950A2 (fr)

Families Citing this family (18)

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ES2450081T3 (es) 2006-06-27 2014-03-21 Takeda Pharmaceutical Company Limited Compuestos cíclicos condensados como moduladores del receptor GPR40
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
TW200936136A (en) * 2008-01-28 2009-09-01 Sanofi Aventis Tetrahydroquinoxaline urea derivatives, their preparation and their therapeutic application
ES2350077B1 (es) 2009-06-04 2011-11-04 Laboratorios Salvat, S.A. Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
FR2948369B1 (fr) * 2009-07-27 2013-04-12 Sanofi Aventis Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique
FR2948370B1 (fr) 2009-07-27 2013-04-05 Sanofi Aventis Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
WO2011157827A1 (fr) 2010-06-18 2011-12-22 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
MX370535B (es) 2013-11-18 2019-12-17 Forma Therapeutics Inc Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer.
US9422281B2 (en) 2013-11-18 2016-08-23 Forma Therapeutics, Inc. Benzopiperazine compositions as BET bromodomain inhibitors
JP2024516455A (ja) * 2021-05-07 2024-04-15 オルガノン・アール・アンド・ディ・フィンランド・リミテッド 新規ヘテロ環式化合物、組成物、その製造および使用方法
CN119630659A (zh) * 2022-06-10 2025-03-14 萨皮恩斯生物有限公司 新型化合物和包含其作为活性成分的药物组合物

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WO1992022552A1 (fr) * 1991-06-14 1992-12-23 The Upjohn Company IMIDAZO[1,5-a]QUINOXALINES
EP1283199A1 (fr) * 2000-05-16 2003-02-12 Takeda Chemical Industries, Ltd. Antagoniste de l'hormone de concentration de la melanine
WO2003031436A1 (fr) * 2001-10-05 2003-04-17 Recordati S.A. Composes heterocycliques utilises pour traiter des troubles de la voie urinaire
WO2004033427A1 (fr) * 2002-10-11 2004-04-22 Astrazeneca Ab Derives de piperidine 1,4 disubstituee et leur utilisation en tant qu'inhibiteurs de 11-betahsd1
WO2005047250A1 (fr) * 2003-11-05 2005-05-26 Astrazeneca Ab Utilisation de 3-(benzoyl)-pyrrolidines n-acylees comme inhibiteurs de 11-beta-hsdi pour le traitement de troubles metaboliques
WO2006053024A2 (fr) * 2004-11-10 2006-05-18 Incyte Corporation Composes de lactame et leur utilisation en temps que substances pharmaceutiques
WO2006055752A2 (fr) * 2004-11-18 2006-05-26 Incyte Corporation INHIBITEURS DE LA 11-β-HYDROXYSTEROIDE DEHYDROGENASE DE TYPE 1 ET PROCEDES D’UTILISATION
WO2006105127A2 (fr) * 2005-03-31 2006-10-05 Takeda San Diego, Inc. Inhibiteurs de l'hydroxysteroide deshydrogenase
WO2006132436A1 (fr) * 2005-06-08 2006-12-14 Japan Tobacco Inc. Composé hétérocyclique

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HUP0202001A2 (hu) 2002-06-14 2005-08-29 Sanofi-Aventis DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
EP1787982B1 (fr) 2003-04-11 2010-05-12 High Point Pharmaceuticals, LLC Composés ayant une activité sur la 11beta-hydroxysteroid dehydrogenase

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WO1992022552A1 (fr) * 1991-06-14 1992-12-23 The Upjohn Company IMIDAZO[1,5-a]QUINOXALINES
EP1283199A1 (fr) * 2000-05-16 2003-02-12 Takeda Chemical Industries, Ltd. Antagoniste de l'hormone de concentration de la melanine
WO2003031436A1 (fr) * 2001-10-05 2003-04-17 Recordati S.A. Composes heterocycliques utilises pour traiter des troubles de la voie urinaire
WO2004033427A1 (fr) * 2002-10-11 2004-04-22 Astrazeneca Ab Derives de piperidine 1,4 disubstituee et leur utilisation en tant qu'inhibiteurs de 11-betahsd1
WO2005047250A1 (fr) * 2003-11-05 2005-05-26 Astrazeneca Ab Utilisation de 3-(benzoyl)-pyrrolidines n-acylees comme inhibiteurs de 11-beta-hsdi pour le traitement de troubles metaboliques
WO2006053024A2 (fr) * 2004-11-10 2006-05-18 Incyte Corporation Composes de lactame et leur utilisation en temps que substances pharmaceutiques
WO2006055752A2 (fr) * 2004-11-18 2006-05-26 Incyte Corporation INHIBITEURS DE LA 11-β-HYDROXYSTEROIDE DEHYDROGENASE DE TYPE 1 ET PROCEDES D’UTILISATION
WO2006105127A2 (fr) * 2005-03-31 2006-10-05 Takeda San Diego, Inc. Inhibiteurs de l'hydroxysteroide deshydrogenase
WO2006132436A1 (fr) * 2005-06-08 2006-12-14 Japan Tobacco Inc. Composé hétérocyclique

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Title
GRZYB J A ET AL: "Carbamoylimidazolium and thiocarbamoylimidazolium salts: novel reagents for the synthesis of ureas, thioureas, carbamates, thiocarbamates and amides", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 61, no. 30, 25 July 2005 (2005-07-25), pages 7153 - 7175, XP004970475, ISSN: 0040-4020 *

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Publication number Publication date
CA2652852A1 (fr) 2008-01-03
MX2008016563A (es) 2009-03-02
BRPI0713042A2 (pt) 2013-01-08
IL195820A0 (en) 2009-09-01
TW200811158A (en) 2008-03-01
US20090176775A1 (en) 2009-07-09
WO2008000950A2 (fr) 2008-01-03
PE20080212A1 (es) 2008-04-25
JP2009541463A (ja) 2009-11-26
AU2007264791A1 (en) 2008-01-03
AR061643A1 (es) 2008-09-10
KR20090021192A (ko) 2009-02-27
US7947834B2 (en) 2011-05-24
CL2007001886A1 (es) 2009-11-10
RU2009102527A (ru) 2010-08-10
UY30448A1 (es) 2008-01-31
EP2044057A2 (fr) 2009-04-08

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