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WO2008119009A3 - Matériaux et procédés pour une production efficace d'alanine - Google Patents

Matériaux et procédés pour une production efficace d'alanine Download PDF

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Publication number
WO2008119009A3
WO2008119009A3 PCT/US2008/058410 US2008058410W WO2008119009A3 WO 2008119009 A3 WO2008119009 A3 WO 2008119009A3 US 2008058410 W US2008058410 W US 2008058410W WO 2008119009 A3 WO2008119009 A3 WO 2008119009A3
Authority
WO
WIPO (PCT)
Prior art keywords
sugars
alanine
efficient
materials
methods
Prior art date
Application number
PCT/US2008/058410
Other languages
English (en)
Other versions
WO2008119009A4 (fr
WO2008119009A2 (fr
Inventor
Xueli Zhang Zhang
Kaemwich Jantama
Jonathan C Moore
Keelnatham T Shanmugam
Lonnie O'neal Ingram
Original Assignee
Univ Florida
Xueli Zhang Zhang
Kaemwich Jantama
Jonathan C Moore
Keelnatham T Shanmugam
Lonnie O'neal Ingram
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida, Xueli Zhang Zhang, Kaemwich Jantama, Jonathan C Moore, Keelnatham T Shanmugam, Lonnie O'neal Ingram filed Critical Univ Florida
Publication of WO2008119009A2 publication Critical patent/WO2008119009A2/fr
Publication of WO2008119009A3 publication Critical patent/WO2008119009A3/fr
Publication of WO2008119009A4 publication Critical patent/WO2008119009A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des micro-organismes génétiquement modifiés qui produisent de la L-alanine comme produit de fermentation primaire à partir de sucres. Des sucres de pentose, tels que le xylose, et des sucres d'hexose, tels que le glucose, peuvent être efficacement fermentés en L-alanine. Les souches décrites ici ont la capacité de métaboliser tous les sucres qui constituent la biomasse lignocellulosique et une variété de disaccharides, y compris le lactose, le maltose, le saccharose et d'autres.
PCT/US2008/058410 2007-03-27 2008-03-27 Matériaux et procédés pour une production efficace d'alanine WO2008119009A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90823407P 2007-03-27 2007-03-27
US60/908,234 2007-03-27

Publications (3)

Publication Number Publication Date
WO2008119009A2 WO2008119009A2 (fr) 2008-10-02
WO2008119009A3 true WO2008119009A3 (fr) 2009-02-26
WO2008119009A4 WO2008119009A4 (fr) 2009-04-16

Family

ID=39789270

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/058410 WO2008119009A2 (fr) 2007-03-27 2008-03-27 Matériaux et procédés pour une production efficace d'alanine

Country Status (1)

Country Link
WO (1) WO2008119009A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040152159A1 (en) 2002-11-06 2004-08-05 Causey Thomas B. Materials and methods for the efficient production of acetate and other products
EP2570481B1 (fr) 2007-03-20 2014-11-26 University of Florida Research Foundation, Inc. Matériaux et procédés de production efficace de succinate et de malate
US8993287B2 (en) 2008-11-18 2015-03-31 University Of Florida Research Foundation, Inc. Biocatalysts and methods for conversion of hemicellulose hydrolysates to biobased products
CA2756705C (fr) 2009-04-02 2017-04-11 University Of Florida Research Foundation, Inc. Cellules bacteriennes modifiees pour production de scuccinate
CN101974476A (zh) * 2010-08-31 2011-02-16 安徽华恒生物工程有限公司 一种高产l-丙氨酸的xz-a26菌株及构建方法与应用
US20150247174A1 (en) * 2012-12-28 2015-09-03 Anhui Huaheng Bioengineering Co., Ltd, Engineering bacteria for producing dl-alanine and method for producing dl-alanine by using engineering bacteria
CN103045528B (zh) * 2012-12-28 2014-05-07 安徽华恒生物工程有限公司 生产dl-丙氨酸的工程菌及利用该工程菌生产dl-丙氨酸的方法
US20160304917A1 (en) * 2013-08-30 2016-10-20 Basf Se Modified Microorganism for Improved Production of Alanine
MY193287A (en) * 2013-12-13 2022-09-30 Basf Se Recombinant microorganism for improved production of fine chemicals
RU2702416C2 (ru) * 2014-04-30 2019-10-08 Эвоник Дегусса Гмбх Способ получения l-аминокислот с помощью алкалифильной бактерии
EP3271467A1 (fr) * 2015-03-18 2018-01-24 Basf Se Micro-organisme recombinant pour la production améliorée de produits chimiques fins
CN104774790B (zh) * 2015-04-03 2020-11-06 江南大学 一种高效发酵生产l-丙氨酸的大肠杆菌
BR112017025923A2 (pt) * 2015-06-04 2018-08-14 Basf Se molécula de ácido nucleico recombinante, molécula de aminoácido recombinante, construto de expressão recombinante, vetor recombinante, micro-organismo recombinante, composição, métodos para produção de um micro-organismo recombinante e para cultivo e crescimento de um micro-organismo geneticamente modificado, uso de uma molécula de ácido nucleico recombinante, e, processo para produção fermentativa de um composto.
CN107690478B (zh) * 2015-06-12 2023-02-03 巴斯夫欧洲公司 用于改善丙氨酸生产的重组微生物
CN110904062B (zh) * 2018-09-18 2022-03-15 安徽华恒生物科技股份有限公司 一株高产l-丙氨酸的菌株
CN110982857A (zh) * 2019-09-23 2020-04-10 安徽丰原生物化学股份有限公司 一种l-丙氨酸的发酵生产方法
CN114457122B (zh) * 2020-05-13 2023-06-20 安徽华恒生物科技股份有限公司 生产l-缬氨酸的重组微生物及构建方法、应用
CN115960942A (zh) * 2021-10-08 2023-04-14 安徽丰原生物技术股份有限公司 一种生产l-丙氨酸的基因工程菌株及其构建方法和应用
CN115960941A (zh) * 2021-10-08 2023-04-14 安徽丰原生物技术股份有限公司 一种生产dl-丙氨酸的基因工程菌株及其构建方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372457B1 (en) * 1997-01-14 2002-04-16 Arkion Life Sciences Llc Process and materials for production of glucosamine
US7037504B2 (en) * 2001-10-23 2006-05-02 Waratah Pharmaceuticals, Inc. Epidermal growth factor protein and gene, and methods of use therefor
US7052883B2 (en) * 2001-04-03 2006-05-30 Degussa Ag Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated fruR gene
US7083942B2 (en) * 2002-03-09 2006-08-01 Degussa Ag Alleles of the aceA gene from coryneform bacteria

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372457B1 (en) * 1997-01-14 2002-04-16 Arkion Life Sciences Llc Process and materials for production of glucosamine
US7052883B2 (en) * 2001-04-03 2006-05-30 Degussa Ag Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated fruR gene
US7037504B2 (en) * 2001-10-23 2006-05-02 Waratah Pharmaceuticals, Inc. Epidermal growth factor protein and gene, and methods of use therefor
US7083942B2 (en) * 2002-03-09 2006-08-01 Degussa Ag Alleles of the aceA gene from coryneform bacteria

Also Published As

Publication number Publication date
WO2008119009A4 (fr) 2009-04-16
WO2008119009A2 (fr) 2008-10-02

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