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WO2008152969A1 - 近赤外発光蛍光体ナノ粒子、その製造方法、それを用いた生体物質標識剤 - Google Patents

近赤外発光蛍光体ナノ粒子、その製造方法、それを用いた生体物質標識剤 Download PDF

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Publication number
WO2008152969A1
WO2008152969A1 PCT/JP2008/060351 JP2008060351W WO2008152969A1 WO 2008152969 A1 WO2008152969 A1 WO 2008152969A1 JP 2008060351 W JP2008060351 W JP 2008060351W WO 2008152969 A1 WO2008152969 A1 WO 2008152969A1
Authority
WO
WIPO (PCT)
Prior art keywords
infrared light
same
near infrared
emitting phosphor
phosphor nanoparticle
Prior art date
Application number
PCT/JP2008/060351
Other languages
English (en)
French (fr)
Inventor
Naoko Furusawa
Kazuya Tsukada
Original Assignee
Konica Minolta Medical & Graphic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konica Minolta Medical & Graphic, Inc. filed Critical Konica Minolta Medical & Graphic, Inc.
Publication of WO2008152969A1 publication Critical patent/WO2008152969A1/ja

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
    • A61K49/0067—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/77—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals
    • C09K11/7766—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals containing two or more rare earth metals
    • C09K11/7777—Phosphates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Luminescent Compositions (AREA)

Abstract

　本発明は、平均粒径が２～５０ｎｍであり、かつ７００～９００ｎｍの範囲内の波長の近赤外光により励起されたときに、７００～２０００ｎｍの範囲内の波長の近赤外光の発光を示す近赤外発光蛍光体ナノ粒子であり、下記一般式（１）で表されることを特徴とし、発光強度が高く生体物質標識剤に適した近赤外発光蛍光体ナノ粒子、その製造方法、及びそれを用いた生体物質標識剤が提供できる。 一般式（１）：（Ｙ）ａ（Ｌｕ）ｂ（Ｌａ）ｃ（Ｎｄ）ｘ（Ｙｂ）ｙ（Ｐｒ）ｍ（Ｔｂ）ｎＰＯ４（式中、ａ＋ｂ＋ｃ＝１－ｘ－ｙ－ｍ－ｎ、０＜ｘ＋ｙ＋ｍ＋ｎ＜１、０≦ａ＜１、０≦ｂ＜１、０≦ｃ＜１、０≦ｍ≦０．１、０≦ｎ≦０．１、０＜ａ＋ｂ＋ｃ＜１かつ０＜ｘ＋ｙ＜１である。）
PCT/JP2008/060351 2007-06-13 2008-06-05 近赤外発光蛍光体ナノ粒子、その製造方法、それを用いた生体物質標識剤 WO2008152969A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007156060 2007-06-13
JP2007-156060 2007-06-13

Publications (1)

Publication Number Publication Date
WO2008152969A1 true WO2008152969A1 (ja) 2008-12-18

Family

ID=40129574

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060351 WO2008152969A1 (ja) 2007-06-13 2008-06-05 近赤外発光蛍光体ナノ粒子、その製造方法、それを用いた生体物質標識剤

Country Status (1)

Country Link
WO (1) WO2008152969A1 (ja)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09127115A (ja) * 1995-01-30 1997-05-16 Dai Ichi Pure Chem Co Ltd 診断用マーカー
JPH1153496A (ja) * 1997-07-31 1999-02-26 Hitachi Maxell Ltd 印刷物
JP2003329686A (ja) * 2002-05-09 2003-11-19 Kenichi Hanaki 発光性微粒子
WO2004085571A1 (en) * 2003-03-24 2004-10-07 Innovation And Development Corporation Lanthanide-doped nanoparticles, their synthesis and uses thereof
JP2005172429A (ja) * 2003-12-05 2005-06-30 Sony Corp 生体物質蛍光標識剤及び生体物質蛍光標識方法、並びにバイオアッセイ方法及び装置
JP2006023140A (ja) * 2004-07-07 2006-01-26 Hitachi Maxell Ltd 複合化粒子
JP2006328032A (ja) * 2005-05-30 2006-12-07 Fujifilm Holdings Corp 核酸プローブ及び多重鎖核酸蛍光検出方法
WO2007034657A1 (ja) * 2005-09-22 2007-03-29 Konica Minolta Medical & Graphic, Inc. 微粒子蛍光体とその製造方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09127115A (ja) * 1995-01-30 1997-05-16 Dai Ichi Pure Chem Co Ltd 診断用マーカー
JPH1153496A (ja) * 1997-07-31 1999-02-26 Hitachi Maxell Ltd 印刷物
JP2003329686A (ja) * 2002-05-09 2003-11-19 Kenichi Hanaki 発光性微粒子
WO2004085571A1 (en) * 2003-03-24 2004-10-07 Innovation And Development Corporation Lanthanide-doped nanoparticles, their synthesis and uses thereof
JP2005172429A (ja) * 2003-12-05 2005-06-30 Sony Corp 生体物質蛍光標識剤及び生体物質蛍光標識方法、並びにバイオアッセイ方法及び装置
JP2006023140A (ja) * 2004-07-07 2006-01-26 Hitachi Maxell Ltd 複合化粒子
JP2006328032A (ja) * 2005-05-30 2006-12-07 Fujifilm Holdings Corp 核酸プローブ及び多重鎖核酸蛍光検出方法
WO2007034657A1 (ja) * 2005-09-22 2007-03-29 Konica Minolta Medical & Graphic, Inc. 微粒子蛍光体とその製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALLPORT J.R. ET AL.: "In vivo imaging of gene and cell therapies", EXPERIMENTAL HEMATOLOGY, vol. 29, 2001, pages 1237 - 1246, XP002969698 *
VAN VEGGEL F.C.J.M.: "Lanthanide(III)-doped nanoparticles that emit in the near infrared", PROC. OF SPIE, vol. 5224, 2003, pages 164 - 175 *

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