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WO2008152969A1 - Near infrared light-emitting phosphor nanoparticle, method for producing the same, and agent for labeling biological substance using the same - Google Patents

Near infrared light-emitting phosphor nanoparticle, method for producing the same, and agent for labeling biological substance using the same Download PDF

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Publication number
WO2008152969A1
WO2008152969A1 PCT/JP2008/060351 JP2008060351W WO2008152969A1 WO 2008152969 A1 WO2008152969 A1 WO 2008152969A1 JP 2008060351 W JP2008060351 W JP 2008060351W WO 2008152969 A1 WO2008152969 A1 WO 2008152969A1
Authority
WO
WIPO (PCT)
Prior art keywords
infrared light
same
near infrared
emitting phosphor
phosphor nanoparticle
Prior art date
Application number
PCT/JP2008/060351
Other languages
French (fr)
Japanese (ja)
Inventor
Naoko Furusawa
Kazuya Tsukada
Original Assignee
Konica Minolta Medical & Graphic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konica Minolta Medical & Graphic, Inc. filed Critical Konica Minolta Medical & Graphic, Inc.
Publication of WO2008152969A1 publication Critical patent/WO2008152969A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
    • A61K49/0067—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/77—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals
    • C09K11/7766—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals containing two or more rare earth metals
    • C09K11/7777—Phosphates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Luminescent Compositions (AREA)

Abstract

Disclosed is a near infrared light-emitting phosphor nanoparticle having an average particle diameter of 2-50 nm, which emits a near infrared light having a wavelength within the range of 700-2000 nm when excited by a near infrared light having a wavelength within the range of 700-900 nm. This near infrared light-emitting phosphor nanoparticle is characterized by being represented by the general formula (1) below, and has high luminous intensity. This near infrared light-emitting phosphor nanoparticle is suitable for an agent for labeling biological substances. Also disclosed are a method for producing such a infrared light-emitting phosphor nanoparticle, and an agent for labeling biological substances using such a infrared light-emitting phosphor nanoparticle. General formula (1): (Y)a(Lu)b(La)c(Nd)x(Yb)y(Pr)m(Tb)nPO4 (In the formula, a + b + c = 1 - x - y - m - n, 0 < x + y + m + n < 1, 0 ≤ a < 1, 0 ≤ b < 1, 0 ≤ c < 1, 0 ≤ m ≤ 0.1, 0 ≤ n ≤ 0.1, 0 < a + b + c < 1 and 0 < x + y < 1.)
PCT/JP2008/060351 2007-06-13 2008-06-05 Near infrared light-emitting phosphor nanoparticle, method for producing the same, and agent for labeling biological substance using the same WO2008152969A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007156060 2007-06-13
JP2007-156060 2007-06-13

Publications (1)

Publication Number Publication Date
WO2008152969A1 true WO2008152969A1 (en) 2008-12-18

Family

ID=40129574

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060351 WO2008152969A1 (en) 2007-06-13 2008-06-05 Near infrared light-emitting phosphor nanoparticle, method for producing the same, and agent for labeling biological substance using the same

Country Status (1)

Country Link
WO (1) WO2008152969A1 (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09127115A (en) * 1995-01-30 1997-05-16 Dai Ichi Pure Chem Co Ltd Diagnostic marker
JPH1153496A (en) * 1997-07-31 1999-02-26 Hitachi Maxell Ltd Printed matter
JP2003329686A (en) * 2002-05-09 2003-11-19 Kenichi Hanaki Luminescent fine particle
WO2004085571A1 (en) * 2003-03-24 2004-10-07 Innovation And Development Corporation Lanthanide-doped nanoparticles, their synthesis and uses thereof
JP2005172429A (en) * 2003-12-05 2005-06-30 Sony Corp Biosubstance fluorescence-labeling agent and method, and bioassay method and device
JP2006023140A (en) * 2004-07-07 2006-01-26 Hitachi Maxell Ltd Compounded particle
JP2006328032A (en) * 2005-05-30 2006-12-07 Fujifilm Holdings Corp Nucleic acid probe and method for fluorescence detection of multiple-stranded nucleic acid
WO2007034657A1 (en) * 2005-09-22 2007-03-29 Konica Minolta Medical & Graphic, Inc. Finely particulate fluorescent material and process for producing the same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09127115A (en) * 1995-01-30 1997-05-16 Dai Ichi Pure Chem Co Ltd Diagnostic marker
JPH1153496A (en) * 1997-07-31 1999-02-26 Hitachi Maxell Ltd Printed matter
JP2003329686A (en) * 2002-05-09 2003-11-19 Kenichi Hanaki Luminescent fine particle
WO2004085571A1 (en) * 2003-03-24 2004-10-07 Innovation And Development Corporation Lanthanide-doped nanoparticles, their synthesis and uses thereof
JP2005172429A (en) * 2003-12-05 2005-06-30 Sony Corp Biosubstance fluorescence-labeling agent and method, and bioassay method and device
JP2006023140A (en) * 2004-07-07 2006-01-26 Hitachi Maxell Ltd Compounded particle
JP2006328032A (en) * 2005-05-30 2006-12-07 Fujifilm Holdings Corp Nucleic acid probe and method for fluorescence detection of multiple-stranded nucleic acid
WO2007034657A1 (en) * 2005-09-22 2007-03-29 Konica Minolta Medical & Graphic, Inc. Finely particulate fluorescent material and process for producing the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALLPORT J.R. ET AL.: "In vivo imaging of gene and cell therapies", EXPERIMENTAL HEMATOLOGY, vol. 29, 2001, pages 1237 - 1246, XP002969698 *
VAN VEGGEL F.C.J.M.: "Lanthanide(III)-doped nanoparticles that emit in the near infrared", PROC. OF SPIE, vol. 5224, 2003, pages 164 - 175 *

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