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WO2008019651A3 - Arrangement for detecting substances, production of said arrangement and use thereof - Google Patents

Arrangement for detecting substances, production of said arrangement and use thereof Download PDF

Info

Publication number
WO2008019651A3
WO2008019651A3 PCT/DE2007/001362 DE2007001362W WO2008019651A3 WO 2008019651 A3 WO2008019651 A3 WO 2008019651A3 DE 2007001362 W DE2007001362 W DE 2007001362W WO 2008019651 A3 WO2008019651 A3 WO 2008019651A3
Authority
WO
WIPO (PCT)
Prior art keywords
substance
arrangement
insulating layer
examination
substrate
Prior art date
Application number
PCT/DE2007/001362
Other languages
German (de)
French (fr)
Other versions
WO2008019651A2 (en
Inventor
Nikolaus Bartels
Bernhard Ay
Prosper Hartig
Michael Portwich
Original Assignee
Nikolaus Bartels
Bernhard Ay
Prosper Hartig
Michael Portwich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikolaus Bartels, Bernhard Ay, Prosper Hartig, Michael Portwich filed Critical Nikolaus Bartels
Publication of WO2008019651A2 publication Critical patent/WO2008019651A2/en
Publication of WO2008019651A3 publication Critical patent/WO2008019651A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to an arrangement and to the use thereof for specifically detecting substances from samples, in particular a biochip, based on a substrate and a connecting layer arranged on a substrate. Said arrangement comprises a connecting layer formed on a carrier substrate and an examination substance coupled to the connecting layer. Said carrier substrate is a semi-conductor substrate and the connecting layer is at least one inorganic insulating layer formed on the semi-conductor substrate. At least one medium and at least one organic examination substance is applied to at least one area on and/or in the insulating layer, and a coupling element is arranged in the at least one relevant area between the insulating layer and the at least one examination substance. The test substance coupled to the insulating layer can interact with a test substance. The invention also relates to a method for producing the arrangement in which at least one medium and at least one organic examination substance is applied to at least one area of an inorganic insulating layer formed on a semi-conductor substrate, and as a result of interactions between the organic examination substance and the inorganic examination substance, a coupling is formed between the organic examination substance and the inorganic insulating layer, and the area is formed in order to interact with a test substance and/or to interact with said examination substance by applying a test substance.
PCT/DE2007/001362 2006-07-31 2007-07-31 Arrangement for detecting substances, production of said arrangement and use thereof WO2008019651A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102006036528 2006-07-31
DE102006036528.3 2006-07-31
DE102006051482A DE102006051482A1 (en) 2006-07-31 2006-10-31 Arrangement for detecting substances, manufacturing the arrangement and its use
DE102006051482.3 2006-10-31

Publications (2)

Publication Number Publication Date
WO2008019651A2 WO2008019651A2 (en) 2008-02-21
WO2008019651A3 true WO2008019651A3 (en) 2008-06-05

Family

ID=38922189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2007/001362 WO2008019651A2 (en) 2006-07-31 2007-07-31 Arrangement for detecting substances, production of said arrangement and use thereof

Country Status (2)

Country Link
DE (1) DE102006051482A1 (en)
WO (1) WO2008019651A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1215186A1 (en) * 2000-12-14 2002-06-19 Commissariat A L'energie Atomique Solid support for the immobilization of oligonucleotides
WO2002048691A1 (en) * 2000-12-14 2002-06-20 Commissariat A L'energie Atomique Device for enhancing wideband fluorescence with low losses and biological or chemical optical sensor using same
US20030082658A1 (en) * 1998-04-10 2003-05-01 Francois Mallet Method for fixing a biological molecule on a support surface
EP1364702A2 (en) * 2002-05-15 2003-11-26 Samsung Electronics Co., Ltd. Process for producing array plate for biomolecules having hydrophilic and hydrophobic regions
EP1542009A1 (en) * 2002-08-12 2005-06-15 Hitachi High-Technologies Corporation Method of detecting nucleic acid by using dna microarrays and nucleic acid detection apparatus
US20060121501A1 (en) * 2004-10-22 2006-06-08 Stanislaw Burzynski Method for immobilizing molecular probes to a semiconductor oxide surface

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL140949A0 (en) * 2001-01-17 2002-02-10 Yeda Res & Dev Nitric oxide (no) detector
US6707038B2 (en) * 2001-02-14 2004-03-16 Picoliter Inc. Method and system using acoustic ejection for selective fluid deposition on a nonuniform sample surface
EP1373574A4 (en) * 2001-03-30 2007-01-03 Ge Healthcare Bio Sciences Ab P450 single nucleotide BIOCHIPs ANALYSIS
US10539561B1 (en) * 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
US20060194327A1 (en) * 2003-07-30 2006-08-31 Koninklijke Philips Electronics N.V. On-chip magnetic particle sensor with improved snr
EP1720015A1 (en) * 2004-03-17 2006-11-08 Matsushita Electric Industrial Co., Ltd. Process for producing biochip, probe solution, and biochip
DE102004021904B4 (en) * 2004-05-04 2011-08-18 Carl Zeiss Microlmaging GmbH, 07745 Method and device for generating an analysis arrangement with discrete, separate measurement ranges for biological, biochemical or chemical analysis
US7364898B2 (en) * 2004-05-04 2008-04-29 Eppendorf Ag Customized micro-array construction and its use for target molecule detection

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030082658A1 (en) * 1998-04-10 2003-05-01 Francois Mallet Method for fixing a biological molecule on a support surface
EP1215186A1 (en) * 2000-12-14 2002-06-19 Commissariat A L'energie Atomique Solid support for the immobilization of oligonucleotides
WO2002048691A1 (en) * 2000-12-14 2002-06-20 Commissariat A L'energie Atomique Device for enhancing wideband fluorescence with low losses and biological or chemical optical sensor using same
EP1364702A2 (en) * 2002-05-15 2003-11-26 Samsung Electronics Co., Ltd. Process for producing array plate for biomolecules having hydrophilic and hydrophobic regions
EP1542009A1 (en) * 2002-08-12 2005-06-15 Hitachi High-Technologies Corporation Method of detecting nucleic acid by using dna microarrays and nucleic acid detection apparatus
US20060121501A1 (en) * 2004-10-22 2006-06-08 Stanislaw Burzynski Method for immobilizing molecular probes to a semiconductor oxide surface

Also Published As

Publication number Publication date
DE102006051482A1 (en) 2008-02-14
WO2008019651A2 (en) 2008-02-21

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