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WO2008066878A3 - Methods and products for diagnosing cancer - Google Patents

Methods and products for diagnosing cancer Download PDF

Info

Publication number
WO2008066878A3
WO2008066878A3 PCT/US2007/024553 US2007024553W WO2008066878A3 WO 2008066878 A3 WO2008066878 A3 WO 2008066878A3 US 2007024553 W US2007024553 W US 2007024553W WO 2008066878 A3 WO2008066878 A3 WO 2008066878A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cancer
products
diagnosing cancer
detection
Prior art date
Application number
PCT/US2007/024553
Other languages
French (fr)
Other versions
WO2008066878A9 (en
WO2008066878A2 (en
Inventor
Marcus Bosenberg
Viswanathan Muthasamy
Sekhar Duraisamy
Original Assignee
Univ Vermont
Marcus Bosenberg
Viswanathan Muthasamy
Sekhar Duraisamy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vermont, Marcus Bosenberg, Viswanathan Muthasamy, Sekhar Duraisamy filed Critical Univ Vermont
Priority to US12/312,807 priority Critical patent/US20100143899A1/en
Publication of WO2008066878A2 publication Critical patent/WO2008066878A2/en
Publication of WO2008066878A3 publication Critical patent/WO2008066878A3/en
Publication of WO2008066878A9 publication Critical patent/WO2008066878A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to methods and kits for the detection and diagnosis of cancer or precancerous conditions. Methylation of specific genes has been identified as indicative of cancer and methods of the invention, in part, relate to the detection of methylation levels in cells as a determination of cancer or a precancerous condition in the cell. In particular, the methylation levels of QPCT, LXN, PCSKl, MFAP2, WFDCl, CDH8 and LRRC2 in melanoma is measured.
PCT/US2007/024553 2005-05-17 2007-11-29 Methods and products for diagnosing cancer WO2008066878A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/312,807 US20100143899A1 (en) 2005-05-17 2007-11-29 Methods and products for diagnosing cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86175506P 2006-11-29 2006-11-29
US60/861,755 2006-11-29

Publications (3)

Publication Number Publication Date
WO2008066878A2 WO2008066878A2 (en) 2008-06-05
WO2008066878A3 true WO2008066878A3 (en) 2008-12-11
WO2008066878A9 WO2008066878A9 (en) 2009-05-28

Family

ID=39468508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/024553 WO2008066878A2 (en) 2005-05-17 2007-11-29 Methods and products for diagnosing cancer

Country Status (1)

Country Link
WO (1) WO2008066878A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8445442B2 (en) 2007-04-26 2013-05-21 University Of Vermont And State Agricultural College CCL18 and CCL3 methods and compositions for detecting and treating cancer
US20110076283A1 (en) * 2008-01-24 2011-03-31 Universite De Lausanne Method for predicting and diagnosing brain tumor
CN101962684B (en) * 2010-11-04 2012-03-28 徐州师范大学 Single nucleotide polymorphism for cattle PCSK1 gene and detection method thereof
WO2012081017A1 (en) 2010-12-15 2012-06-21 Yeda Research And Development Co. Ltd. Compositions and methods for treating cancer and neurodegenerative diseases
EP3037545A1 (en) * 2014-12-23 2016-06-29 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin A DNA-methylation test for prostate cancer
WO2020019268A1 (en) * 2018-07-26 2020-01-30 北京艾克伦医疗科技有限公司 Method for identifying state of breast cancer and kit
CN114410792B (en) * 2022-02-10 2023-07-25 博尔诚（北京）科技有限公司 Marker for kidney cancer screening, probe composition and application thereof
CN118441051B (en) * 2024-05-28 2025-05-02 南通大学 MeQTL-SNPs biomarker related to lung adenocarcinoma and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095644A2 (en) * 2004-04-04 2005-10-13 Oligene Gmbh Method for recognizing signatures in complex gene expression profiles
WO2007149269A2 (en) * 2006-06-12 2007-12-27 Oncomethylome Sciences S.A. Methylation markers for early detection and prognosis of colon cancers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095644A2 (en) * 2004-04-04 2005-10-13 Oligene Gmbh Method for recognizing signatures in complex gene expression profiles
WO2007149269A2 (en) * 2006-06-12 2007-12-27 Oncomethylome Sciences S.A. Methylation markers for early detection and prognosis of colon cancers

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FURUTA JUNICHI ET AL: "Silencing of the thrombomodulin gene in human malignant melanoma", MELANOMA RESEARCH, vol. 15, no. 1, February 2005 (2005-02-01), pages 15 - 20, XP009103389, ISSN: 0960-8931 *
GILLIS JOHN STUART: "Microarray evidence of glutaminyl cyclase gene expression in melanoma: implications for tumor antigen specific immunotherapy", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, vol. 4, no. 1, 4 July 2006 (2006-07-04), pages 27, XP021018978, ISSN: 1479-5876 *
KORABIOWSKA MONIKA ET AL: "Analysis of adenomatous polyposis coli gene expression, APC locus-microsatellite instability and APC promoter methylation in the progression of melanocytic tumours", MODERN PATHOLOGY, vol. 17, no. 12, December 2004 (2004-12-01), pages 1539 - 1544, XP002489097, ISSN: 0893-3952 *
MIRMOHAMMADSADEGH ALIREZA ET AL: "Epigenetic silencing of the PTEN gene in melanoma.", CANCER RESEARCH 1 JUL 2006, vol. 66, no. 13, 1 July 2006 (2006-07-01), pages 6546 - 6552, XP002489096, ISSN: 0008-5472 *
MUTHUSAMY VISWANATHAN ET AL: "Epigenetic silencing of novel tumor suppressors in malignant melanoma", CANCER RESEARCH, vol. 66, no. 23, December 2006 (2006-12-01), pages 11187 - 11193, XP002489098, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
WO2008066878A9 (en) 2009-05-28
WO2008066878A2 (en) 2008-06-05

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