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WO2008060568A3 - Arylpipéridines à substitution amide - Google Patents

Arylpipéridines à substitution amide Download PDF

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Publication number
WO2008060568A3
WO2008060568A3 PCT/US2007/023936 US2007023936W WO2008060568A3 WO 2008060568 A3 WO2008060568 A3 WO 2008060568A3 US 2007023936 W US2007023936 W US 2007023936W WO 2008060568 A3 WO2008060568 A3 WO 2008060568A3
Authority
WO
WIPO (PCT)
Prior art keywords
amide
substituted aryl
cgrp
compounds
methods
Prior art date
Application number
PCT/US2007/023936
Other languages
English (en)
Other versions
WO2008060568A2 (fr
Inventor
Rajagopal Bakthavatchalam
Scott M Capitosti
Alan J Hutchison
Guiying Li
John M Peterson
Charles S Cheng
Original Assignee
Neurogen Corp
Rajagopal Bakthavatchalam
Scott M Capitosti
Alan J Hutchison
Guiying Li
John M Peterson
Charles S Cheng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp, Rajagopal Bakthavatchalam, Scott M Capitosti, Alan J Hutchison, Guiying Li, John M Peterson, Charles S Cheng filed Critical Neurogen Corp
Publication of WO2008060568A2 publication Critical patent/WO2008060568A2/fr
Publication of WO2008060568A3 publication Critical patent/WO2008060568A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'invention concerne des dérivés d'arylpipéridines à substitution amide de formules A, I et II dans lesquelles les variables sont telles que définies dans la description. Ces composés peuvent être utilisés pour moduler l'activité des récepteurs au peptide alternatif du gène de la calcitonine (CGRP) in vivo ou in vitro, et peuvent en particulier être employés pour traiter des états sensibles à une modulation du CGRP, y compris les céphalées telles que la migraine, chez les êtres humains, les animaux domestiques de compagnie, et le bétail. Cette invention concerne également des compositions pharmaceutiques et leurs procédés d'utilisation pour traiter ce type de troubles, ainsi que des procédés d'utilisation desdits composés pour réaliser des études de localisation de récepteur et divers essais in vitro.
PCT/US2007/023936 2006-11-15 2007-11-14 Arylpipéridines à substitution amide WO2008060568A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86586206P 2006-11-15 2006-11-15
US60/865,862 2006-11-15

Publications (2)

Publication Number Publication Date
WO2008060568A2 WO2008060568A2 (fr) 2008-05-22
WO2008060568A3 true WO2008060568A3 (fr) 2008-08-21

Family

ID=39402246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/023936 WO2008060568A2 (fr) 2006-11-15 2007-11-14 Arylpipéridines à substitution amide

Country Status (1)

Country Link
WO (1) WO2008060568A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006039038A1 (de) * 2006-08-19 2008-02-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Herstellungsverfahren
JP5592388B2 (ja) * 2008-10-31 2014-09-17 メルク・シャープ・アンド・ドーム・コーポレーション 疼痛治療用のｐ２ｘ３受容体アンタゴニスト技術分野
WO2010070022A1 (fr) * 2008-12-19 2010-06-24 Boehringer Ingelheim International Gmbh Nouveaux composés
KR20220098160A (ko) * 2019-11-06 2022-07-11 바이엘 악티엔게젤샤프트 아드레날린수용체 adrac2의 억제제

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812226B2 (en) * 1999-12-17 2004-11-02 Astrazeneca Ab P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease
US20050096345A1 (en) * 2003-07-10 2005-05-05 Aventis Pharma S.A. Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use
US20050256302A1 (en) * 2002-06-04 2005-11-17 Japan Science And Technology Agency Novel peptides having camp producing activity
US20060229301A1 (en) * 2003-04-18 2006-10-12 Rena Nishizawa Spiro-piperidine compounds and medicinal use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812226B2 (en) * 1999-12-17 2004-11-02 Astrazeneca Ab P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease
US20050256302A1 (en) * 2002-06-04 2005-11-17 Japan Science And Technology Agency Novel peptides having camp producing activity
US20060229301A1 (en) * 2003-04-18 2006-10-12 Rena Nishizawa Spiro-piperidine compounds and medicinal use thereof
US20050096345A1 (en) * 2003-07-10 2005-05-05 Aventis Pharma S.A. Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use

Also Published As

Publication number Publication date
WO2008060568A2 (fr) 2008-05-22

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