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WO2008016811A3 - Aminopipéridines et composés apparentés - Google Patents

Aminopipéridines et composés apparentés Download PDF

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Publication number
WO2008016811A3
WO2008016811A3 PCT/US2007/074282 US2007074282W WO2008016811A3 WO 2008016811 A3 WO2008016811 A3 WO 2008016811A3 US 2007074282 W US2007074282 W US 2007074282W WO 2008016811 A3 WO2008016811 A3 WO 2008016811A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
aminopiperidines
realted
methods
disorders
Prior art date
Application number
PCT/US2007/074282
Other languages
English (en)
Other versions
WO2008016811A2 (fr
Inventor
Manuka Ghosh
Christopher K Seekamp
Xuechun Zhang
James G Tarrant
Che-Wah Lee
Bernd Kaiser
Mary-Margaret Zablocki
Bertrand L Chenard
Dario Doller
Yasuchika Yamaguchi
David J Wustrow
Guiying Li
Original Assignee
Neurogen Corp
Manuka Ghosh
Christopher K Seekamp
Xuechun Zhang
James G Tarrant
Che-Wah Lee
Bernd Kaiser
Mary-Margaret Zablocki
Bertrand L Chenard
Dario Doller
Yasuchika Yamaguchi
David J Wustrow
Guiying Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp, Manuka Ghosh, Christopher K Seekamp, Xuechun Zhang, James G Tarrant, Che-Wah Lee, Bernd Kaiser, Mary-Margaret Zablocki, Bertrand L Chenard, Dario Doller, Yasuchika Yamaguchi, David J Wustrow, Guiying Li filed Critical Neurogen Corp
Publication of WO2008016811A2 publication Critical patent/WO2008016811A2/fr
Publication of WO2008016811A3 publication Critical patent/WO2008016811A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fodder In General (AREA)

Abstract

L'invention concerne des aminopipéridines et des composés apparentés représentés par les formules dans lesquelles des variables sont décrites dans les présentes. De tels composés peuvent être utilisés pour moduler l'activité du récepteur MCH in vivo ou in vitro, et sont particulièrement utiles dans le traitement d'une diversité de troubles métaboliques, de l'alimentation et sexuels chez les êtres humains, les animaux de compagnie domestiqués et les animaux de bétail. L'invention concerne des compositions pharmaceutiques et des procédés pour traiter de tels troubles, ainsi que des procédés pour utiliser de tels ligands pour détecter les récepteurs MCH (par exemple, études de l'emplacement des récepteurs).
PCT/US2007/074282 2006-07-31 2007-07-25 Aminopipéridines et composés apparentés WO2008016811A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82083406P 2006-07-31 2006-07-31
US60/820,834 2006-07-31

Publications (2)

Publication Number Publication Date
WO2008016811A2 WO2008016811A2 (fr) 2008-02-07
WO2008016811A3 true WO2008016811A3 (fr) 2008-10-09

Family

ID=38997770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074282 WO2008016811A2 (fr) 2006-07-31 2007-07-25 Aminopipéridines et composés apparentés

Country Status (1)

Country Link
WO (1) WO2008016811A2 (fr)

Families Citing this family (30)

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Publication number Priority date Publication date Assignee Title
TWI411395B (zh) * 2007-12-24 2013-10-11 Syngenta Participations Ag 殺蟲化合物
WO2009101917A1 (fr) 2008-02-13 2009-08-20 Eisai R & D Management Co., Ltd. Dérivé de bicycloamine
EP2280966A1 (fr) * 2008-03-14 2011-02-09 Exelixis, Inc. Dérivés azabicyclo [3.2.1]octyles en tant que modulateurs de 11-bêta-hsd1
CN101981025A (zh) * 2008-03-28 2011-02-23 万有制药株式会社 具有黑色素浓缩激素受体拮抗作用的二芳基甲基酰胺衍生物
JO2911B1 (en) 2008-04-11 2015-09-15 جانسن فارمسيتكا ان في Thiazoloperidine-2-amoxicillinyl-phenyl and thiazoloperazine-2-amoxicillinyl phenyl amine as agents for the control of leukotrien A4 hydrolase
WO2010050456A1 (fr) * 2008-10-30 2010-05-06 萬有製薬株式会社 Composé pipéridine ayant une structure di- ou tri-arylméthyle
BRPI1012205A2 (pt) 2009-05-14 2019-04-02 Janssen Pharmaceutica Nv compostos com duas porções heteroarila bicíclica fundidas como moduladores de leucotrieno a4 hidrolase
US9409918B2 (en) * 2009-10-29 2016-08-09 Merck Sharp & Dohme Corp. Bridged bicyclic piperidine derivatives and methods of use thereof
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
US8877795B2 (en) 2010-05-07 2014-11-04 The Board Of Trustees Of The Leland Stanford Junior University Identification of stabilizers of multimeric proteins
US9562055B2 (en) 2011-05-13 2017-02-07 Array Biopharma Inc. Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors
WO2014078378A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-pyrrolidinyle urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
WO2014078325A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-aryle monocycliques, n'-pyrazolyl-urée, thiourée, guanidine et cyanoguanidine utiles comme inhibiteurs de trka kinase
US9981959B2 (en) 2012-11-13 2018-05-29 Array Biopharma Inc. Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078328A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-pyrrolidinyle, n'-pyrazolyl-urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
ME02990B (fr) 2012-11-13 2018-10-20 Array Biopharma Inc Composés de n-pyrrolidinyle, n'-pyrazolyl-urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
CN104903310B (zh) 2012-11-13 2018-08-14 阵列生物制药公司 可用于治疗疼痛的双环脲、硫脲、胍及氰基胍化合物
US9809578B2 (en) 2012-11-13 2017-11-07 Array Biopharma Inc. Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors
WO2014078331A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-(arylalkyle)-n'-pyrazolyle-urée, de thiourée, de guanidine et de cyanoguanidine en tant qu'inhibiteurs de la kinase trka
US9790178B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9822118B2 (en) 2012-11-13 2017-11-21 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
WO2015046595A1 (fr) * 2013-09-30 2015-04-02 国立大学法人東京大学 Composé activateur du récepteur de l'adiponectine
US10835533B2 (en) 2014-05-15 2020-11-17 Array Biopharma Inc. 1 -((3S,4R)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-yl)urea as a TrkA kinase inhibitor
US20160045609A1 (en) 2014-08-14 2016-02-18 Mamoun M. Alhamadsheh Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life
BR112017003745A2 (pt) 2014-08-29 2017-12-05 Tes Pharma S R L inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico
EP3649108A1 (fr) * 2017-07-03 2020-05-13 GlaxoSmithKline Intellectual Property Development Limited Dérivés de 2-(4-chlorophénoxy)-n-((1-(2-(4-chlorophénoxy)éthynazétidine-3-yl)méthyl)acétamide et composés apparentés servant d'inhibiteurs d'atf4 pour le traitement du cancer et d'autres maladies
EP3682906A1 (fr) * 2019-01-17 2020-07-22 Julius-Maximilians-Universität Würzburg Composé ciblant le transporteur de norépinéphrine
AU2022318635A1 (en) * 2021-07-26 2024-02-01 Zoetis Services Llc Serotonin 5-ht2b inhibitory compounds
CN115124473B (zh) * 2022-07-12 2023-11-10 河北科技大学 西咪替丁有关物质b的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028616A (en) * 1989-09-05 1991-07-02 G. D. Searle & Co. N-benzylpiperidine amides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028616A (en) * 1989-09-05 1991-07-02 G. D. Searle & Co. N-benzylpiperidine amides

Also Published As

Publication number Publication date
WO2008016811A2 (fr) 2008-02-07

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