WO2007136664A3 - Formulation antibiotique et procédé de traitement - Google Patents
Formulation antibiotique et procédé de traitement Download PDFInfo
- Publication number
- WO2007136664A3 WO2007136664A3 PCT/US2007/011754 US2007011754W WO2007136664A3 WO 2007136664 A3 WO2007136664 A3 WO 2007136664A3 US 2007011754 W US2007011754 W US 2007011754W WO 2007136664 A3 WO2007136664 A3 WO 2007136664A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drug
- formulation
- treatment
- particles
- therapeutically effective
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000003115 biocidal effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229920000249 biocompatible polymer Polymers 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 230000000399 orthopedic effect Effects 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Abstract
La présente invention concerne une formulation contenant des particules qui peuvent être groupées et sont constituées d'un polymère biocompatible et d'un médicament antimicrobien, la formulation étant destinée à la libération contrôlée du médicament. Les particules peuvent se trouver dans une solution aqueuse comportant de la thrombine et être dispersées dans un gel. La formulation est appliquée sur une région telle qu'une plaie ouverte renfermant un implant orthopédique et elle libère une quantité thérapeutiquement efficace de médicament chez le patient durant un laps de temps thérapeutiquement efficace.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/383,562 | 2006-05-16 | ||
US11/383,562 US20060263401A1 (en) | 2001-07-13 | 2006-05-16 | Formulation and Method for Preventing Infection |
US80526706P | 2006-06-20 | 2006-06-20 | |
US60/805,267 | 2006-06-20 | ||
US82166806P | 2006-08-07 | 2006-08-07 | |
US60/821,668 | 2006-08-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007136664A2 WO2007136664A2 (fr) | 2007-11-29 |
WO2007136664A3 true WO2007136664A3 (fr) | 2008-05-02 |
Family
ID=38723813
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/011753 WO2007136663A2 (fr) | 2006-05-16 | 2007-05-16 | Formulation de protéine morphogène osseuse/antibiotique et procédé de traitement |
PCT/US2007/011754 WO2007136664A2 (fr) | 2006-05-16 | 2007-05-16 | Formulation antibiotique et procédé de traitement |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/011753 WO2007136663A2 (fr) | 2006-05-16 | 2007-05-16 | Formulation de protéine morphogène osseuse/antibiotique et procédé de traitement |
Country Status (1)
Country | Link |
---|---|
WO (2) | WO2007136663A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20200330380A1 (en) * | 2019-04-18 | 2020-10-22 | DePuy Synthes Products, Inc. | Biocompatible organogel matrices for intraoperative preparation of a drug delivery depot |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4728512A (en) * | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
US6228398B1 (en) * | 1998-11-02 | 2001-05-08 | Elan Corporation, Plc | Multiparticulate modified release composition |
US20020165608A1 (en) * | 2001-05-07 | 2002-11-07 | Llanos Gerard H. | Local drug delivery devices and methods for maintaining the drug coatings thereon |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
US5939323A (en) * | 1996-05-28 | 1999-08-17 | Brown University | Hyaluronan based biodegradable scaffolds for tissue repair |
US6743446B2 (en) * | 1999-12-15 | 2004-06-01 | The Ohio State University Research Foundation | Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers |
-
2007
- 2007-05-16 WO PCT/US2007/011753 patent/WO2007136663A2/fr active Application Filing
- 2007-05-16 WO PCT/US2007/011754 patent/WO2007136664A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4728512A (en) * | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
US6228398B1 (en) * | 1998-11-02 | 2001-05-08 | Elan Corporation, Plc | Multiparticulate modified release composition |
US20020165608A1 (en) * | 2001-05-07 | 2002-11-07 | Llanos Gerard H. | Local drug delivery devices and methods for maintaining the drug coatings thereon |
Also Published As
Publication number | Publication date |
---|---|
WO2007136663A2 (fr) | 2007-11-29 |
WO2007136663A3 (fr) | 2008-11-06 |
WO2007136664A2 (fr) | 2007-11-29 |
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