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WO2007136663A3 - Formulation de protéine morphogène osseuse/antibiotique et procédé de traitement - Google Patents

Formulation de protéine morphogène osseuse/antibiotique et procédé de traitement Download PDF

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Publication number
WO2007136663A3
WO2007136663A3 PCT/US2007/011753 US2007011753W WO2007136663A3 WO 2007136663 A3 WO2007136663 A3 WO 2007136663A3 US 2007011753 W US2007011753 W US 2007011753W WO 2007136663 A3 WO2007136663 A3 WO 2007136663A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibiotic
treatment
drug
bone morphogenic
morphogenic protein
Prior art date
Application number
PCT/US2007/011753
Other languages
English (en)
Other versions
WO2007136663A2 (fr
Inventor
Reid M Rubsamen
Original Assignee
Flow Focusing Inc
Reid M Rubsamen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/383,562 external-priority patent/US20060263401A1/en
Application filed by Flow Focusing Inc, Reid M Rubsamen filed Critical Flow Focusing Inc
Publication of WO2007136663A2 publication Critical patent/WO2007136663A2/fr
Publication of WO2007136663A3 publication Critical patent/WO2007136663A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne une formulation contenant des particules qui peuvent être groupées et sont constituées d'un polymère biocompatible et d'un médicament antimicrobien, la formulation étant destinée à la libération contrôlée du médicament. Les particules peuvent se trouver dans une solution aqueuse comportant de la thrombine et être dispersées dans un gel. La formulation est appliquée sur une région telle qu'une plaie ouverte renfermant un implant orthopédique et elle libère une quantité thérapeutiquement efficace de médicament chez le patient durant un laps de temps thérapeutiquement efficace.
PCT/US2007/011753 2006-05-16 2007-05-16 Formulation de protéine morphogène osseuse/antibiotique et procédé de traitement WO2007136663A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11/383,562 US20060263401A1 (en) 2001-07-13 2006-05-16 Formulation and Method for Preventing Infection
US11/383,562 2006-05-16
US80526706P 2006-06-20 2006-06-20
US60/805,267 2006-06-20
US82166806P 2006-08-07 2006-08-07
US60/821,668 2006-08-07

Publications (2)

Publication Number Publication Date
WO2007136663A2 WO2007136663A2 (fr) 2007-11-29
WO2007136663A3 true WO2007136663A3 (fr) 2008-11-06

Family

ID=38723813

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/011753 WO2007136663A2 (fr) 2006-05-16 2007-05-16 Formulation de protéine morphogène osseuse/antibiotique et procédé de traitement
PCT/US2007/011754 WO2007136664A2 (fr) 2006-05-16 2007-05-16 Formulation antibiotique et procédé de traitement

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2007/011754 WO2007136664A2 (fr) 2006-05-16 2007-05-16 Formulation antibiotique et procédé de traitement

Country Status (1)

Country Link
WO (2) WO2007136663A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200330380A1 (en) * 2019-04-18 2020-10-22 DePuy Synthes Products, Inc. Biocompatible organogel matrices for intraoperative preparation of a drug delivery depot

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5939323A (en) * 1996-05-28 1999-08-17 Brown University Hyaluronan based biodegradable scaffolds for tissue repair
US6743446B2 (en) * 1999-12-15 2004-06-01 The Ohio State University Research Foundation Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728512A (en) * 1985-05-06 1988-03-01 American Home Products Corporation Formulations providing three distinct releases
EP1126826B3 (fr) * 1998-11-02 2019-05-15 Alkermes Pharma Ireland Limited Composition de methylphenidate a liberation modifiee multiparticulaire
US7261735B2 (en) * 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5939323A (en) * 1996-05-28 1999-08-17 Brown University Hyaluronan based biodegradable scaffolds for tissue repair
US6743446B2 (en) * 1999-12-15 2004-06-01 The Ohio State University Research Foundation Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LOBATO, J.V. ET AL., THIN SOLID FILMS, vol. 515, January 2006 (2006-01-01), pages 362 - 367, XP025007132 *

Also Published As

Publication number Publication date
WO2007136663A2 (fr) 2007-11-29
WO2007136664A3 (fr) 2008-05-02
WO2007136664A2 (fr) 2007-11-29

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