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WO2007118844A1 - Pyrazolopyrimidines substituées, leur procédé de préparation, leur utilisation pour lutter contre les champignons nuisibles, et agents les contenant - Google Patents

Pyrazolopyrimidines substituées, leur procédé de préparation, leur utilisation pour lutter contre les champignons nuisibles, et agents les contenant Download PDF

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Publication number
WO2007118844A1
WO2007118844A1 PCT/EP2007/053592 EP2007053592W WO2007118844A1 WO 2007118844 A1 WO2007118844 A1 WO 2007118844A1 EP 2007053592 W EP2007053592 W EP 2007053592W WO 2007118844 A1 WO2007118844 A1 WO 2007118844A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
compounds
formula
compound
corresponds
Prior art date
Application number
PCT/EP2007/053592
Other languages
German (de)
English (en)
Inventor
Jochen Dietz
Thomas Grote
Bernd Müller
Jan Klaas Lohmann
Jens Renner
Sarah Ulmschneider
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of WO2007118844A1 publication Critical patent/WO2007118844A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Definitions

  • n 0, 1 or 2;
  • a 1 is hydrogen, hydroxy, C 1 -C 8 -alkyl, C 1 -C -haloalkyl, amino,
  • the reaction is carried out without solvent or an inert organic solvent can be used, for example an aprotic polar solvent.
  • the reaction can be carried out in the presence of a catalyst, for example a base [cf. EP-A 770 615].
  • a catalyst for example a base [cf. EP-A 770 615].
  • it may also be preferable to react in the presence of an acid, for example a carboxylic acid such as. Acetic acid or using a corresponding acid addition salt of V, for example the sulphate of V, under conditions well known to those skilled in the art.
  • the bases are generally used in catalytic amounts, but they can also be used equimolar, in excess or optionally as a solvent.
  • Ci-Cs-alkyl as mentioned above, wherein one or more hydrogen atoms, preferably a hydrogen atom, are replaced by as defined below drdi-cycloalkyloxy groups.
  • Ci-Cs-alkyl as mentioned above, wherein one or more hydrogen atoms, preferably a hydrogen atom, are replaced by as defined below C6-Ci4-aryloxy groups.
  • Haloalkenyloxy alkenyloxy, as defined above, wherein in these groups the hydrogen atoms are partially or completely replaced by halogen atoms, as described above under haloalkenyl, in particular fluorine, chlorine or bromine, z. Chlorovinyloxy, chloroallyloxy and the like.
  • Di (Ci-C8-alkyl) -aminocarbonyl radical of the formula RR'N-C (O) -, in which R and R 'are independently of Ci-Cs-alkyl.
  • Alkyl stands.
  • W 6 in the abovementioned embodiments is preferably selected from C 1 -C 6 -alkyl, C 3 -C 6 -alkenyl, C 1 -C 8 -cycloalkyl, benzyl, CONW 7 OW 7 , COOW 8 , carboxy-C 1 -C 4 -alkyl and CN.
  • R 1 is hydrogen, fluorine, chlorine or bromine, in particular hydrogen.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I), dans laquelle les substituants sont tels que définis dans la description. L'invention concerne également des agents fongicides et pharmaceutiques contenant ces composés, ainsi que leur utilisation pour lutter contre les champignons pathogènes des plantes et contre le cancer.
PCT/EP2007/053592 2006-04-13 2007-04-12 Pyrazolopyrimidines substituées, leur procédé de préparation, leur utilisation pour lutter contre les champignons nuisibles, et agents les contenant WO2007118844A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP06112634 2006-04-13
EP06112634.8 2006-04-13
EP06122268.3 2006-10-13
EP06122268 2006-10-13

Publications (1)

Publication Number Publication Date
WO2007118844A1 true WO2007118844A1 (fr) 2007-10-25

Family

ID=38190901

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/053592 WO2007118844A1 (fr) 2006-04-13 2007-04-12 Pyrazolopyrimidines substituées, leur procédé de préparation, leur utilisation pour lutter contre les champignons nuisibles, et agents les contenant

Country Status (3)

Country Link
AR (1) AR060466A1 (fr)
CL (1) CL2007001067A1 (fr)
WO (1) WO2007118844A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10800782B2 (en) 2016-08-31 2020-10-13 Agios Pharmaceutical, Inc. Inhibitors of cellular metabolic processes

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2794745A1 (fr) * 1999-06-14 2000-12-15 American Cyanamid Co 6-phenylpyrazolopyrimidines fongicides
JP2002308878A (ja) * 2001-04-13 2002-10-23 Nippon Soda Co Ltd アゾロピリミジン化合物、その製造方法及び農園芸用殺菌剤
WO2003101993A1 (fr) * 2002-06-04 2003-12-11 Neogenesis Pharmaceuticals, Inc. Composes de pyrazolo(1,5a)pyrimidine servant d'agents antiviraux
WO2004022560A1 (fr) * 2002-09-04 2004-03-18 Schering Corporation Pyrazolopyrimidines utilisees en tant qu'inhibiteurs des kinases cycline-dependantes
WO2004026229A2 (fr) * 2002-09-04 2004-04-01 Schering Corporation Nouveaux pyrazolopyrimidines en tant qu'inhibiteurs de la kinase dependantes des cyclines
WO2004087707A1 (fr) * 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Composes pyrazolopyrimidines et leur utilisation en medecine

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2794745A1 (fr) * 1999-06-14 2000-12-15 American Cyanamid Co 6-phenylpyrazolopyrimidines fongicides
JP2002308878A (ja) * 2001-04-13 2002-10-23 Nippon Soda Co Ltd アゾロピリミジン化合物、その製造方法及び農園芸用殺菌剤
WO2003101993A1 (fr) * 2002-06-04 2003-12-11 Neogenesis Pharmaceuticals, Inc. Composes de pyrazolo(1,5a)pyrimidine servant d'agents antiviraux
US20040038993A1 (en) * 2002-06-04 2004-02-26 Neogenesis Pharmaceuticals, Inc. Pyrazolo[1,5a]pyrimidine compounds as antiviral agents
WO2004022560A1 (fr) * 2002-09-04 2004-03-18 Schering Corporation Pyrazolopyrimidines utilisees en tant qu'inhibiteurs des kinases cycline-dependantes
WO2004026229A2 (fr) * 2002-09-04 2004-04-01 Schering Corporation Nouveaux pyrazolopyrimidines en tant qu'inhibiteurs de la kinase dependantes des cyclines
WO2004087707A1 (fr) * 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Composes pyrazolopyrimidines et leur utilisation en medecine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10800782B2 (en) 2016-08-31 2020-10-13 Agios Pharmaceutical, Inc. Inhibitors of cellular metabolic processes
US11325914B1 (en) 2016-08-31 2022-05-10 Servier Pharmaceuticals Llc Inhibitors of cellular metabolic processes
USRE49934E1 (en) 2016-08-31 2024-04-23 Servier Pharmaceuticals Llc Inhibitors of cellular metabolic processes

Also Published As

Publication number Publication date
AR060466A1 (es) 2008-06-18
CL2007001067A1 (es) 2008-06-13

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