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WO2007012671A3 - Procédé d'immunisation génétique par électrotransfert contre une toxine et antisérum susceptible d'être obtenu par ledit procédé - Google Patents

Procédé d'immunisation génétique par électrotransfert contre une toxine et antisérum susceptible d'être obtenu par ledit procédé Download PDF

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Publication number
WO2007012671A3
WO2007012671A3 PCT/EP2006/064798 EP2006064798W WO2007012671A3 WO 2007012671 A3 WO2007012671 A3 WO 2007012671A3 EP 2006064798 W EP2006064798 W EP 2006064798W WO 2007012671 A3 WO2007012671 A3 WO 2007012671A3
Authority
WO
WIPO (PCT)
Prior art keywords
toxin
electrotransfer
antiserum
genetic immunization
obtainable
Prior art date
Application number
PCT/EP2006/064798
Other languages
English (en)
Other versions
WO2007012671A2 (fr
WO2007012671A9 (fr
Inventor
Daniel Scherman
Pascal Bigey
Capucine Trollet
Michel R Popoff
Yannick Pereira
Original Assignee
Centre Nat Rech Scient
Pasteur Institut
Inst Nat Sante Rech Med
Univ Rene Descartes
Daniel Scherman
Pascal Bigey
Capucine Trollet
Michel R Popoff
Yannick Pereira
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Pasteur Institut, Inst Nat Sante Rech Med, Univ Rene Descartes, Daniel Scherman, Pascal Bigey, Capucine Trollet, Michel R Popoff, Yannick Pereira filed Critical Centre Nat Rech Scient
Priority to CA002617082A priority Critical patent/CA2617082A1/fr
Priority to US11/989,573 priority patent/US20100129371A1/en
Priority to JP2008523373A priority patent/JP2009502880A/ja
Priority to EP06778059A priority patent/EP1906996A2/fr
Publication of WO2007012671A2 publication Critical patent/WO2007012671A2/fr
Publication of WO2007012671A9 publication Critical patent/WO2007012671A9/fr
Publication of WO2007012671A3 publication Critical patent/WO2007012671A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention a pour objet un procédé d'obtention d'un antisérum dirigé contre une toxine protéique par administration chez un animal d'une solution comprenant une construction génétique codant un fragment immunogène de toxine, suivie de l'application d'un champ électrique dans la zone d'administration, et isolement du sérum. L'antisérum susceptible d'être obtenu par le procédé ainsi que l'utilisation de la solution pour la fabrication d'un médicament destiné à prévenir ou à traiter un effet toxique lié à l'absorption chez un mammifère d'une toxine, caractérisée en ce que ledit médicament est formulé en vue d'une administration par électrotransfert, sont également compris dans l'invention.
PCT/EP2006/064798 2005-07-28 2006-07-28 Procédé d'immunisation génétique par électrotransfert contre une toxine et antisérum susceptible d'être obtenu par ledit procédé WO2007012671A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002617082A CA2617082A1 (fr) 2005-07-28 2006-07-28 Procede d'immunisation genetique par electrotransfert contre une toxine et antiserum susceptible d'etre obtenu par ledit procede
US11/989,573 US20100129371A1 (en) 2005-07-28 2006-07-28 Method for genetic immunization by electrotransfer against a toxin and antiserum obtainable by said method
JP2008523373A JP2009502880A (ja) 2005-07-28 2006-07-28 毒素に対する電気移動による遺伝子免疫法および前記方法によって得られる抗血清
EP06778059A EP1906996A2 (fr) 2005-07-28 2006-07-28 Procédé d'immunisation génétique par électrotransfert contre une toxine et antisérum susceptible d'être obtenu par ledit procédé

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0508065A FR2889066B1 (fr) 2005-07-28 2005-07-28 Procede d'immunisation genetique par electrotransfert contre une toxine et antiserum susceptible d'etre obtenu par ledit procede
FR0508065 2005-07-28

Publications (3)

Publication Number Publication Date
WO2007012671A2 WO2007012671A2 (fr) 2007-02-01
WO2007012671A9 WO2007012671A9 (fr) 2007-03-15
WO2007012671A3 true WO2007012671A3 (fr) 2007-04-26

Family

ID=36101879

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/064798 WO2007012671A2 (fr) 2005-07-28 2006-07-28 Procédé d'immunisation génétique par électrotransfert contre une toxine et antisérum susceptible d'être obtenu par ledit procédé

Country Status (6)

Country Link
US (1) US20100129371A1 (fr)
EP (1) EP1906996A2 (fr)
JP (1) JP2009502880A (fr)
CA (1) CA2617082A1 (fr)
FR (1) FR2889066B1 (fr)
WO (1) WO2007012671A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2928373B1 (fr) 2008-03-05 2010-12-31 Centre Nat Rech Scient Polymere derive de la polyethylenimine lineaire pour le transfert de gene.
CA2799470A1 (fr) * 2010-05-14 2011-11-17 The Children's Hospital Of Philadelphia Ttc humanise et procedes d'utilisation associes
CN105209066A (zh) * 2013-03-15 2015-12-30 宾夕法尼亚大学理事会 使用来自肉毒梭菌的血清型的重链的基于单价或多价肉毒杆菌神经毒素的疫苗
CN111122455B (zh) * 2019-12-20 2022-10-25 华南协同创新研究院 一种食品真菌毒素结构的稳定性判定方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001158A1 (fr) * 1997-06-30 1999-01-14 Rhone-Poulenc Rorer S.A. Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede
WO2000067700A2 (fr) * 1999-05-12 2000-11-16 United States Army Medical Research & Materiel Cmd Vaccin de recombinaison contre la neurotoxine botulique
WO2003012117A1 (fr) * 2001-07-28 2003-02-13 The Secretary Of State For Defence Vaccin a adn

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020195A (en) * 1996-09-18 2000-02-01 Roche Diagnostics Gmbh Antibodies against hepatitis G virus and their use for the diagnostic detection of HGV and as a therapeutic agent
US20040248262A1 (en) * 2003-01-22 2004-12-09 Koeberl Dwight D. Constructs for expressing lysomal polypeptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001158A1 (fr) * 1997-06-30 1999-01-14 Rhone-Poulenc Rorer S.A. Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede
WO2000067700A2 (fr) * 1999-05-12 2000-11-16 United States Army Medical Research & Materiel Cmd Vaccin de recombinaison contre la neurotoxine botulique
WO2003012117A1 (fr) * 2001-07-28 2003-02-13 The Secretary Of State For Defence Vaccin a adn

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BACHY MONIQUE ET AL: "Electric pulses increase the immunogenicity of an influenza DNA vaccine injected intramuscularly in the mouse", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 19, no. 13-14, 8 February 2001 (2001-02-08), pages 1688 - 1693, XP002183367, ISSN: 0264-410X *
BLOQUEL CAROLE ET AL: "Plasmid DNA electrotransfer for intracellular and secreted proteins expression: new methodological developments and applications.", THE JOURNAL OF GENE MEDICINE. FEB 2004, vol. 6 Suppl 1, February 2004 (2004-02-01), pages S11 - S23, XP009064942, ISSN: 1099-498X *
DURIEUX ANNE-CÉCILE ET AL: "Kinetic of transgene expression after electrotransfer into skeletal muscle: importance of promoter origin/strength.", BIOCHIMICA ET BIOPHYSICA ACTA. 10 OCT 2005, vol. 1725, no. 3, 12 July 2005 (2005-07-12), pages 403 - 409, XP002376182, ISSN: 0006-3002 *
GARMORY HELEN S ET AL: "DNA vaccines for biodefence.", ADVANCED DRUG DELIVERY REVIEWS. 17 JUN 2005, vol. 57, no. 9, 17 June 2005 (2005-06-17), pages 1343 - 1361, XP004921415, ISSN: 0169-409X *
MCMAHON J M ET AL: "Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase -- increased expression with reduced muscle damage.", GENE THERAPY. AUG 2001, vol. 8, no. 16, August 2001 (2001-08-01), pages 1264 - 1270, XP009005905, ISSN: 0969-7128 *
MCMAHON JILLIAN M ET AL: "Electroporation for gene transfer to skeletal muscles: current status.", BIODRUGS : CLINICAL IMMUNOTHERAPEUTICS, BIOPHARMACEUTICALS AND GENE THERAPY. 2004, vol. 18, no. 3, 2004, pages 155 - 165, XP009064939, ISSN: 1173-8804 *
SHYU R-H ET AL: "DNA VACCINATION USING THE FRAGMENT C OF BOTULINUM NEUROTOXIN TYPE A PROVIDED PROTECTIVE IMMUNITY IN MICE", JOURNAL OF BIOMEDICAL SCIENCE, KARGER, BASEL, CH, vol. 7, no. 1, 2000, pages 51 - 57, XP009002343, ISSN: 1021-7770 *

Also Published As

Publication number Publication date
CA2617082A1 (fr) 2007-02-01
EP1906996A2 (fr) 2008-04-09
WO2007012671A2 (fr) 2007-02-01
WO2007012671A9 (fr) 2007-03-15
FR2889066B1 (fr) 2007-11-09
FR2889066A1 (fr) 2007-02-02
US20100129371A1 (en) 2010-05-27
JP2009502880A (ja) 2009-01-29

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