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WO2007009702A3 - Composes de pyrazoline substitues, leur preparation et leur utilisation comme medicaments - Google Patents

Composes de pyrazoline substitues, leur preparation et leur utilisation comme medicaments Download PDF

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Publication number
WO2007009702A3
WO2007009702A3 PCT/EP2006/006976 EP2006006976W WO2007009702A3 WO 2007009702 A3 WO2007009702 A3 WO 2007009702A3 EP 2006006976 W EP2006006976 W EP 2006006976W WO 2007009702 A3 WO2007009702 A3 WO 2007009702A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
pyrazoline compounds
substituted pyrazoline
reducing triglycerides
predetermined stereochemistry
Prior art date
Application number
PCT/EP2006/006976
Other languages
English (en)
Other versions
WO2007009702A2 (fr
Inventor
Altisen Maria Rosa Cuberes
Original Assignee
Esteve Labor Dr
Altisen Maria Rosa Cuberes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05384022A external-priority patent/EP1743889A1/fr
Application filed by Esteve Labor Dr, Altisen Maria Rosa Cuberes filed Critical Esteve Labor Dr
Publication of WO2007009702A2 publication Critical patent/WO2007009702A2/fr
Publication of WO2007009702A3 publication Critical patent/WO2007009702A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des composés de pyrazoline substitués, leurs méthodes de préparation et des médicaments contenant ces composés. Elle concerne également l'utilisation des composés pour la préparation d'un médicament destiné au traitement d'êtres humains et d'animaux.
PCT/EP2006/006976 2005-07-15 2006-07-15 Composes de pyrazoline substitues, leur preparation et leur utilisation comme medicaments WO2007009702A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05384022A EP1743889A1 (fr) 2005-07-15 2005-07-15 Composés de pyrazolines substituées ayant une stereochimie predeterminèe pour réduire des triglycerides dans le sang
EP05384022.9 2005-07-15
US70543605P 2005-08-05 2005-08-05
US60/705,436 2005-08-05

Publications (2)

Publication Number Publication Date
WO2007009702A2 WO2007009702A2 (fr) 2007-01-25
WO2007009702A3 true WO2007009702A3 (fr) 2007-04-05

Family

ID=36950414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/006976 WO2007009702A2 (fr) 2005-07-15 2006-07-15 Composes de pyrazoline substitues, leur preparation et leur utilisation comme medicaments

Country Status (2)

Country Link
ES (1) ES2336883B1 (fr)
WO (1) WO2007009702A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1209326A (en) * 1966-09-27 1970-10-21 Carter Wallace The preparation of 3-methyl-5-pyrazole carboxylic acid amides
WO1988005046A2 (fr) * 1987-01-05 1988-07-14 E.I. Du Pont De Nemours And Company Pyrazolines insecticides
WO2002080909A1 (fr) * 2001-04-06 2002-10-17 Laboratorios Del Dr. Esteve, S.A. Utilisation de derives de pyrazolines dans l'elaboration d'un medicament pour la prevention et/ou le traitement de maladies proliferatives cellulaires
WO2005077909A1 (fr) * 2004-02-17 2005-08-25 Laboratorios Dr. Esteve S.A. Composes de pyrazoline substitues permettant de reduire le taux de triglycerides dans le sang

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2137138B1 (es) * 1998-05-29 2000-09-16 Esteve Labor Dr Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
US20040122033A1 (en) * 2002-12-10 2004-06-24 Nargund Ravi P. Combination therapy for the treatment of obesity
ES2326725B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazolina sustituidos para el tratamiento de trastornos alimentarios, que incluyen la obesidad o el sindrome metabolico en pacientes con diabetes desarrollada.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1209326A (en) * 1966-09-27 1970-10-21 Carter Wallace The preparation of 3-methyl-5-pyrazole carboxylic acid amides
WO1988005046A2 (fr) * 1987-01-05 1988-07-14 E.I. Du Pont De Nemours And Company Pyrazolines insecticides
WO2002080909A1 (fr) * 2001-04-06 2002-10-17 Laboratorios Del Dr. Esteve, S.A. Utilisation de derives de pyrazolines dans l'elaboration d'un medicament pour la prevention et/ou le traitement de maladies proliferatives cellulaires
WO2005077909A1 (fr) * 2004-02-17 2005-08-25 Laboratorios Dr. Esteve S.A. Composes de pyrazoline substitues permettant de reduire le taux de triglycerides dans le sang

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADAMS J ET AL: "Recent advances in the cannabinoids", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 12, no. 10, 2002, pages 1475 - 1489, XP002353808, ISSN: 1354-3776 *
MESCHLER J P ET AL: "Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)- 1-(2, dichlorophenyl)-4-methyl-1H-pyrazole-3- carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyr azole-3-carboxylic acid phenylamide (CP-272871) for the CB1 cannabinoid receptor", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 60, 2000, pages 1315 - 1323, XP002262541, ISSN: 0006-2952 *

Also Published As

Publication number Publication date
WO2007009702A2 (fr) 2007-01-25
ES2336883A1 (es) 2010-04-16
ES2336883B1 (es) 2011-03-22

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