WO2006110309A3 - Souris transgeniques exprimant une population unique de lymphocytes b et methodes d'utilisation - Google Patents
Souris transgeniques exprimant une population unique de lymphocytes b et methodes d'utilisation Download PDFInfo
- Publication number
- WO2006110309A3 WO2006110309A3 PCT/US2006/011105 US2006011105W WO2006110309A3 WO 2006110309 A3 WO2006110309 A3 WO 2006110309A3 US 2006011105 W US2006011105 W US 2006011105W WO 2006110309 A3 WO2006110309 A3 WO 2006110309A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- transgenic mice
- unique
- methods
- transgenic
- cell population
- Prior art date
Links
- 241000699660 Mus musculus Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000011830 transgenic mouse model Methods 0.000 title abstract 2
- 241001465754 Metazoa Species 0.000 abstract 3
- 230000009261 transgenic effect Effects 0.000 abstract 3
- 108020003175 receptors Proteins 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108010083359 Antigen Receptors Proteins 0.000 abstract 1
- 108091026890 Coding region Proteins 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention porte sur des animaux transgéniques, tels que des souris transgéniques, qui expriment une forme dominante-négative de RAG-I dans la phase de transition du développement des lymphocytes B, ce qui permet un réarrangement initial génétique du récepteur à l'antigène, mais bloque l'édition du récepteur et/ou la révision du récepteur qui se produit pendant les dernières phases du développement. Selon un aspect de cette invention, l'animal transgénique comprend dans son génome un polynucléotide exogène comprenant une séquence codante codant un polypeptide RAG-I catalytiquement défectueux ou un analogue de celui-ci. L'invention porte également sur des méthodes de fabrication et d'utilisation de ces animaux transgéniques.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66540605P | 2005-03-26 | 2005-03-26 | |
| US60/665,406 | 2005-03-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2006110309A2 WO2006110309A2 (fr) | 2006-10-19 |
| WO2006110309A3 true WO2006110309A3 (fr) | 2007-01-18 |
| WO2006110309A9 WO2006110309A9 (fr) | 2007-04-19 |
Family
ID=37087489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2006/011105 WO2006110309A2 (fr) | 2005-03-26 | 2006-03-27 | Souris transgeniques exprimant une population unique de lymphocytes b et methodes d'utilisation |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2006110309A2 (fr) |
-
2006
- 2006-03-27 WO PCT/US2006/011105 patent/WO2006110309A2/fr active Application Filing
Non-Patent Citations (4)
| Title |
|---|
| FURUSAWA T ET AL: "Catalytic RAG1 mutants obstruct V(D)J recombination in vitro and in vivo.", MOLECULAR IMMUNOLOGY, vol. 39, no. 14, May 2003 (2003-05-01), pages 871 - 878, XP002407203, ISSN: 0161-5890 * |
| KIM D R ET AL: "Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase", GENES AND DEVELOPMENT, vol. 13, no. 23, December 1999 (1999-12-01), pages 3070 - 3080, XP002407205, ISSN: 0890-9369 * |
| LANDREE M A ET AL: "Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination", GENES AND DEVELOPMENT, vol. 13, no. 23, December 1999 (1999-12-01), pages 3059 - 3069, XP002407204, ISSN: 0890-9369 * |
| PARKS K W ET AL: "Transgenic mice expressing catalytically inactive RAG-1 exhibit hypogammaglobulinemia and altered B cell development, but not autoreactivity", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 117, no. 2, Suppl. S, February 2006 (2006-02-01), & 62ND ANNUAL MEETING OF THE AMERICAN-ACADEMY-OF-ALLERGY-ASTHMA-AND-IMM UNOLOGY; MIAMI BEACH, FL, USA; MARCH 03 -07, 2006, pages S100, XP002407202, ISSN: 0091-6749 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006110309A2 (fr) | 2006-10-19 |
| WO2006110309A9 (fr) | 2007-04-19 |
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