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WO2006008038A8 - Methyliden-d-xylopyranosyl- und oxo-d-xylopyranosyl-substituierte phenyle, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung - Google Patents

Methyliden-d-xylopyranosyl- und oxo-d-xylopyranosyl-substituierte phenyle, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

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Publication number
WO2006008038A8
WO2006008038A8 PCT/EP2005/007582 EP2005007582W WO2006008038A8 WO 2006008038 A8 WO2006008038 A8 WO 2006008038A8 EP 2005007582 W EP2005007582 W EP 2005007582W WO 2006008038 A8 WO2006008038 A8 WO 2006008038A8
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WO
WIPO (PCT)
Prior art keywords
xylopyranosyl
substituted
methylidene
oxo
compounds
Prior art date
Application number
PCT/EP2005/007582
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English (en)
French (fr)
Other versions
WO2006008038A1 (de
Inventor
Matthias Eckhardt
Frank Himmelsbach
Peter Eickelmann
Leo Thomas
Edward Leon Barsoumian
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Pharma
Matthias Eckhardt
Frank Himmelsbach
Peter Eickelmann
Leo Thomas
Edward Leon Barsoumian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Pharma, Matthias Eckhardt, Frank Himmelsbach, Peter Eickelmann, Leo Thomas, Edward Leon Barsoumian filed Critical Boehringer Ingelheim Int
Priority to JP2007521855A priority Critical patent/JP2008506734A/ja
Priority to CA002572819A priority patent/CA2572819A1/en
Priority to EP05771787A priority patent/EP1771460A1/de
Publication of WO2006008038A1 publication Critical patent/WO2006008038A1/de
Publication of WO2006008038A8 publication Critical patent/WO2006008038A8/de

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    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

D-Xylopyranosyl-substituierte Phenyle der allgemeinen Formel (I), wobei die Reste R1 bis R5, X, Z sowie R7a, R7b, R7c wie in Anspruch 1 definiert sind, besitzen eine inhibierende Wirkung auf den natriumabhängigen Glucose-Cotransporter SGLT. Die vorliegende Erfindung betrifft auch Arzneimittel zur Behandlung von Stoffwechselerkrankungen.
PCT/EP2005/007582 2004-07-17 2005-07-13 Methyliden-d-xylopyranosyl- und oxo-d-xylopyranosyl-substituierte phenyle, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung WO2006008038A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2007521855A JP2008506734A (ja) 2004-07-17 2005-07-13 メチリデン−ｄ−キシロピラノシル置換及びオキソ−ｄ−キシロピラノシル置換フェニル、これらの化合物を含む薬剤、それらの使用及びそれらの製造方法
CA002572819A CA2572819A1 (en) 2004-07-17 2005-07-13 Methylidene-d-xylopyranosyl-substituted and oxo-d-xylopyranosyl-substituted phenyls, medicaments containing these compounds, their use and method for the production thereof
EP05771787A EP1771460A1 (de) 2004-07-17 2005-07-13 Methyliden-d-xylopyranosyl- und oxo-d-xylopyranosyl-substituierte phenyle, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004034690.9 2004-07-17
DE102004034690A DE102004034690A1 (de) 2004-07-17 2004-07-17 Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Publications (2)

Publication Number Publication Date
WO2006008038A1 WO2006008038A1 (de) 2006-01-26
WO2006008038A8 true WO2006008038A8 (de) 2006-05-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/007582 WO2006008038A1 (de) 2004-07-17 2005-07-13 Methyliden-d-xylopyranosyl- und oxo-d-xylopyranosyl-substituierte phenyle, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

Country Status (6)

Country Link
US (1) US20060019948A1 (de)
EP (1) EP1771460A1 (de)
JP (1) JP2008506734A (de)
CA (1) CA2572819A1 (de)
DE (1) DE102004034690A1 (de)
WO (1) WO2006008038A1 (de)

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