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WO2002008190A3 - Neue heteroaryl-derivate und deren verwendung als antitumormittel - Google Patents

Neue heteroaryl-derivate und deren verwendung als antitumormittel Download PDF

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Publication number
WO2002008190A3
WO2002008190A3 PCT/EP2001/008262 EP0108262W WO0208190A3 WO 2002008190 A3 WO2002008190 A3 WO 2002008190A3 EP 0108262 W EP0108262 W EP 0108262W WO 0208190 A3 WO0208190 A3 WO 0208190A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumour agents
heteroaryl derivatives
novel heteroaryl
novel
derivatives
Prior art date
Application number
PCT/EP2001/008262
Other languages
English (en)
French (fr)
Other versions
WO2002008190A2 (de
Inventor
Peter Emig
Eckhard Guenther
Juergen Schmidt
Bernhard Kutscher
Bernd Nickel
Anita Storch
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ524156A priority Critical patent/NZ524156A/en
Priority to MXPA03000596A priority patent/MXPA03000596A/es
Priority to KR10-2003-7000880A priority patent/KR20030015894A/ko
Priority to HU0300743A priority patent/HUP0300743A2/hu
Priority to EP01960509A priority patent/EP1305289A2/de
Priority to SK194-2003A priority patent/SK1942003A3/sk
Priority to JP2002514097A priority patent/JP2004516243A/ja
Priority to AU8198901A priority patent/AU8198901A/xx
Priority to BR0112711-0A priority patent/BR0112711A/pt
Priority to IL15393101A priority patent/IL153931A0/xx
Application filed by Zentaris Ag filed Critical Zentaris Ag
Priority to PL36135401A priority patent/PL361354A1/xx
Priority to AU2001281989A priority patent/AU2001281989B2/en
Publication of WO2002008190A2 publication Critical patent/WO2002008190A2/de
Publication of WO2002008190A3 publication Critical patent/WO2002008190A3/de
Priority to NO20030302A priority patent/NO20030302L/no
Priority to BG107506A priority patent/BG107506A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Die Erfindung betrifft neue Pyridin-Derivate der allgemeinen Formel (1), deren Herstellung und Verwendung als Arzneimittel, insbesondere zur Behandlung von Tumoren.
PCT/EP2001/008262 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel WO2002008190A2 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
BR0112711-0A BR0112711A (pt) 2000-07-21 2001-07-18 Derivados de heteroarila e seus usos como medicamentos
KR10-2003-7000880A KR20030015894A (ko) 2000-07-21 2001-07-18 신규한 헤테로아릴 유도체 및 약물로서의 이의 용도
HU0300743A HUP0300743A2 (hu) 2000-07-21 2001-07-18 Heteroarilszármazékok és alkalmazásuk gyógyszerként
EP01960509A EP1305289A2 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel
SK194-2003A SK1942003A3 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
JP2002514097A JP2004516243A (ja) 2000-07-21 2001-07-18 新規のヘテロアリール誘導体および該化合物の医薬品としての使用
AU8198901A AU8198901A (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as medicaments
NZ524156A NZ524156A (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and their use as medicaments
MXPA03000596A MXPA03000596A (es) 2000-07-21 2001-07-18 Nuevos derivasdos de heteroarilo y su uso como agentes antitumorales.
IL15393101A IL153931A0 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
PL36135401A PL361354A1 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
AU2001281989A AU2001281989B2 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
NO20030302A NO20030302L (no) 2000-07-21 2003-01-20 Nye heteroarylderivater og deres anvendelse som medikamenter
BG107506A BG107506A (bg) 2000-07-21 2003-01-30 Нови хетероарилови производни и тяхното използване като лекарствени средства

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035908A DE10035908A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10035908.6 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002008190A2 WO2002008190A2 (de) 2002-01-31
WO2002008190A3 true WO2002008190A3 (de) 2002-08-01

Family

ID=7649970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008262 WO2002008190A2 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel

Country Status (21)

Country Link
US (1) US6638935B2 (de)
EP (1) EP1305289A2 (de)
JP (1) JP2004516243A (de)
KR (1) KR20030015894A (de)
CN (1) CN1447796A (de)
AR (1) AR032467A1 (de)
AU (2) AU8198901A (de)
BG (1) BG107506A (de)
BR (1) BR0112711A (de)
CA (1) CA2353353A1 (de)
DE (1) DE10035908A1 (de)
HU (1) HUP0300743A2 (de)
IL (1) IL153931A0 (de)
MX (1) MXPA03000596A (de)
NO (1) NO20030302L (de)
NZ (1) NZ524156A (de)
PL (1) PL361354A1 (de)
RU (1) RU2003105238A (de)
SK (1) SK1942003A3 (de)
WO (1) WO2002008190A2 (de)
ZA (1) ZA200300545B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014744A1 (en) * 2002-04-05 2004-01-22 Fortuna Haviv Substituted pyridines having antiangiogenic activity
BR0312294A (pt) * 2002-06-29 2005-04-12 Zentaris Gmbh Arilcarbonil piperazinas e hteroarilcarbonilpiperazinas e o uso das mesmas para tratamento de doenças benignas e malignas
AU2004218260A1 (en) * 2003-01-28 2004-09-16 Aventis Pharma S.A. N-aryl heteroaromatic products, compositions containing same and use thereof
PE20050226A1 (es) * 2003-06-04 2005-05-18 Aventis Pharma Sa Productos aril-heteroaromaticos y composiciones que los contienen
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
FR2871157A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Produits biaryl aromatiques, compositions les contenant et utilisation
EP1645556A1 (de) * 2004-10-07 2006-04-12 Boehringer Ingelheim International GmbH Arylpiperazin-Benzoylamidderivate geeignet als Arzneimittelwirkstoffe
MX2009008253A (es) 2007-01-31 2009-10-12 Vertex Pharma Derivados de 2-aminopiridina utiles como inhibidores de cinasa.
EP2125750B1 (de) * 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Zyklische harnstoff- und carbamat-hemmer aus 11-beta-hydroxysteroid-dehydrogenase 1
EP2183229B1 (de) * 2007-07-26 2012-04-18 Vitae Pharmaceuticals, Inc. Synthese von 11-beta-hydroxysteroid-dehydrogenase-1-hemmern
CN101903384A (zh) 2007-11-02 2010-12-01 沃泰克斯药物股份有限公司 作为蛋白激酶Cθ抑制剂的[1H-吡唑并[3,4-B]吡啶-4-基]-苯基或-吡啶-2-基衍生物
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
WO2009102428A2 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-OXAZEPAN-2-ONE AND 1,3-DIAZEPAN-2-ONE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
WO2009102460A2 (en) * 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2274287B1 (de) * 2008-03-18 2016-03-09 Vitae Pharmaceuticals, Inc. Inhibitoren der 11beta-hydroxysteroiddehydrogenase vom typ 1
CA2722427A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001058A1 (es) 2008-05-01 2010-09-10 Vitae Pharmaceuticals Inc Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras.
EP2291373B1 (de) * 2008-05-01 2013-09-11 Vitae Pharmaceuticals, Inc. Cyclische inhibitoren von 11beta-hydroxysteroiddehydrogenase 1
US8592410B2 (en) 2008-05-01 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1
EP2328896B1 (de) 2008-07-23 2013-10-23 Vertex Pharmaceuticals Incorporated Tricyclische pyrazolopyridine als kinaseinhibitoren
NZ590784A (en) 2008-07-23 2012-12-21 Vertex Pharma Pyrazolopyridine kinase inhibitors
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
WO2010127237A2 (en) * 2009-04-30 2010-11-04 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2324018B1 (de) 2008-07-25 2013-09-04 Boehringer Ingelheim International GmbH Cyclische inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2732765A1 (en) * 2008-08-06 2010-02-11 Vertex Pharmaceuticals Incorporated Aminopyridine kinase inhibitors
CA2744946A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN102459259A (zh) 2009-05-06 2012-05-16 沃泰克斯药物股份有限公司 吡唑并吡啶类
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
US8883778B2 (en) 2009-07-01 2014-11-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
MX2012008643A (es) 2010-01-27 2013-02-26 Vertex Pharma Inhibidores de cinasas de pirazolopiridinas.
EP2550272A1 (de) 2010-01-27 2013-01-30 Vertex Pharmaceuticals Incorporated Pyrazolopyrazinkinasehemmer
WO2011094273A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
CN103179960A (zh) 2010-11-02 2013-06-26 贝林格尔.英格海姆国际有限公司 治疗代谢疾病的药物组合

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2215545A1 (de) * 1971-03-31 1972-10-12 Egyt Gyogyszervegyeszeti Gyar, Budapest Pyridinderivate und ihre Salze sowie ihre Verwendung und Verfahren zur Herstellung derselben
DE2240665A1 (de) * 1971-11-19 1974-03-07 Albert Ag Chem Werke Verfahren zur herstellung von n,n'disubstituierten cyclischen diaminen
JPS50151886A (de) * 1974-05-29 1975-12-06
DE2828888A1 (de) * 1977-06-30 1979-01-18 Egyt Gyogyszervegyeszeti Gyar Verfahren zur herstellung von pyridincarbonsaeureamiden
EP0040793A1 (de) * 1980-05-22 1981-12-02 Masayuki Ishikawa Chinazolindion-Verbindungen, Verfahren zu deren Herstellung und deren pharmazeutische Verwendung
EP0318235A2 (de) * 1987-11-25 1989-05-31 Takeda Chemical Industries, Ltd. PAF-Antagonist, 1,4-disubstituierte Piperazin-Verbindungen und deren Herstellung
EP0350448A1 (de) * 1988-07-07 1990-01-10 Ciba-Geigy Ag Biarylverbindungen
WO1995000497A1 (en) * 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1996021648A1 (en) * 1995-01-11 1996-07-18 Samjin Pharmaceutical Co., Ltd. New piperazine derivatives and methods for the preparation thereof and compositions containing the same
WO1996028427A1 (en) * 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
WO1998000402A1 (en) * 1996-06-29 1998-01-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
WO1999043682A1 (en) * 1998-02-26 1999-09-02 Neurogen Corporation 2-(het-)aryl-4-(cyclic amino substituted) heteroaryl fused pyridine derivatives, their preparation and their use as (ant-)agonists for gaba (a) brain receptors
EP1006110A1 (de) * 1997-07-21 2000-06-07 Laboratorios Del Dr. Esteve, S.A. Derivate von acyl-piperazinil-pyrimidinen, ihre herstellung und verwendung als medikament
WO2000052001A1 (en) * 1999-03-03 2000-09-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
WO2000076521A1 (en) * 1999-06-15 2000-12-21 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
WO2001044201A1 (en) * 1999-12-16 2001-06-21 Schering Corporation Substituted imidazole neuropeptide y y5 receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410540B1 (en) * 1998-08-28 2002-06-25 Scios, Inc. Inhibitors of p38-αkinase

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2215545A1 (de) * 1971-03-31 1972-10-12 Egyt Gyogyszervegyeszeti Gyar, Budapest Pyridinderivate und ihre Salze sowie ihre Verwendung und Verfahren zur Herstellung derselben
DE2240665A1 (de) * 1971-11-19 1974-03-07 Albert Ag Chem Werke Verfahren zur herstellung von n,n'disubstituierten cyclischen diaminen
JPS50151886A (de) * 1974-05-29 1975-12-06
DE2828888A1 (de) * 1977-06-30 1979-01-18 Egyt Gyogyszervegyeszeti Gyar Verfahren zur herstellung von pyridincarbonsaeureamiden
EP0040793A1 (de) * 1980-05-22 1981-12-02 Masayuki Ishikawa Chinazolindion-Verbindungen, Verfahren zu deren Herstellung und deren pharmazeutische Verwendung
EP0318235A2 (de) * 1987-11-25 1989-05-31 Takeda Chemical Industries, Ltd. PAF-Antagonist, 1,4-disubstituierte Piperazin-Verbindungen und deren Herstellung
EP0350448A1 (de) * 1988-07-07 1990-01-10 Ciba-Geigy Ag Biarylverbindungen
WO1995000497A1 (en) * 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1996021648A1 (en) * 1995-01-11 1996-07-18 Samjin Pharmaceutical Co., Ltd. New piperazine derivatives and methods for the preparation thereof and compositions containing the same
WO1996028427A1 (en) * 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
WO1998000402A1 (en) * 1996-06-29 1998-01-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
EP1006110A1 (de) * 1997-07-21 2000-06-07 Laboratorios Del Dr. Esteve, S.A. Derivate von acyl-piperazinil-pyrimidinen, ihre herstellung und verwendung als medikament
WO1999043682A1 (en) * 1998-02-26 1999-09-02 Neurogen Corporation 2-(het-)aryl-4-(cyclic amino substituted) heteroaryl fused pyridine derivatives, their preparation and their use as (ant-)agonists for gaba (a) brain receptors
WO2000052001A1 (en) * 1999-03-03 2000-09-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
WO2000076521A1 (en) * 1999-06-15 2000-12-21 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
WO2001044201A1 (en) * 1999-12-16 2001-06-21 Schering Corporation Substituted imidazole neuropeptide y y5 receptor antagonists

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ACTA CHIM. ACAD. SCI. HUNG. (1980), 105(4), 241-6 *
ACTA POL. PHARM. (1967), 24(3), 225-9 *
BIOORG. MED. CHEM. LETT. (2000), 10(24), 2819-2823 *
CHEMICAL ABSTRACTS, vol. 104, Columbus, Ohio, US; abstract no. 142076, TRUBITSYNA, T. K. ET AL: "Comparative anorexic activity and other pharmacological properties of quipazine and its N-acyl derivatives" XP002185956 *
CHEMICAL ABSTRACTS, vol. 134, Columbus, Ohio, US; abstract no. 207791, KANOJIA, R. M. ET AL: "Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines" XP002185955 *
CHEMICAL ABSTRACTS, vol. 68, Columbus, Ohio, US; abstract no. 59531, BINIECKI, STANISLAW ET AL: "Synthesis of 1,4-bis(pyridylcarbonyl)piperazines" XP002185958 *
CHEMICAL ABSTRACTS, vol. 84, no. 25, 21 June 1976, Columbus, Ohio, US; abstract no. 180288, IRIKURA, TSUTOMU: "1-(3-Phenylpropyl)-4-pyridinecarbonyl-piperazine derivatives" XP002185954 *
CHEMICAL ABSTRACTS, vol. 94, Columbus, Ohio, US; abstract no. 192275, BUDAI, ZOLTAN ET AL: "A novel synthesis of pyridinecarboxylic acid piperazides" XP002185959 *
CHEMICAL ABSTRACTS, vol. 95, Columbus, Ohio, US; abstract no. 42145, BENASSI, ROIS ET AL: "Proton dynamic nuclear magnetic resonance study of hindered internal rotation in N-aroyl- and N-thioaroyl-N'-piperonylpiperazines" XP002185957 *
FARMAKOL. TOKSIKOL. (MOSCOW) (1986), 49(1), 44-9 *
ORG. MAGN. RESON. (1981), 15(1), 25-8 *

Also Published As

Publication number Publication date
CA2353353A1 (en) 2002-01-21
JP2004516243A (ja) 2004-06-03
US6638935B2 (en) 2003-10-28
US20020111354A1 (en) 2002-08-15
RU2003105238A (ru) 2004-08-10
NO20030302L (no) 2003-02-07
CN1447796A (zh) 2003-10-08
AR032467A1 (es) 2003-11-12
SK1942003A3 (en) 2003-12-02
AU2001281989B2 (en) 2005-05-12
IL153931A0 (en) 2003-07-31
BG107506A (bg) 2003-09-30
BR0112711A (pt) 2003-05-20
MXPA03000596A (es) 2003-05-14
KR20030015894A (ko) 2003-02-25
WO2002008190A2 (de) 2002-01-31
HUP0300743A2 (hu) 2003-10-28
AU8198901A (en) 2002-02-05
NO20030302D0 (no) 2003-01-20
ZA200300545B (en) 2003-02-12
EP1305289A2 (de) 2003-05-02
PL361354A1 (en) 2004-10-04
DE10035908A1 (de) 2002-03-07
NZ524156A (en) 2005-10-28

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