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WO2006005459A3 - Diagnostics and therapeutics for diseases associated with thyrotropin-releasing hormone degrading ectoenzyme (trhde) - Google Patents

Diagnostics and therapeutics for diseases associated with thyrotropin-releasing hormone degrading ectoenzyme (trhde) Download PDF

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Publication number
WO2006005459A3
WO2006005459A3 PCT/EP2005/007144 EP2005007144W WO2006005459A3 WO 2006005459 A3 WO2006005459 A3 WO 2006005459A3 EP 2005007144 W EP2005007144 W EP 2005007144W WO 2006005459 A3 WO2006005459 A3 WO 2006005459A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
trhde
thyrotropin
therapeutics
diagnostics
Prior art date
Application number
PCT/EP2005/007144
Other languages
French (fr)
Other versions
WO2006005459A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Publication of WO2006005459A2 publication Critical patent/WO2006005459A2/en
Publication of WO2006005459A3 publication Critical patent/WO2006005459A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human TRHDE which is associated with the cardiovascular diseases, infections, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of TRHDE as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/007144 2004-07-15 2005-07-02 Diagnostics and therapeutics for diseases associated with thyrotropin-releasing hormone degrading ectoenzyme (trhde) WO2006005459A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04016635.7 2004-07-15
EP04016635 2004-07-15

Publications (2)

Publication Number Publication Date
WO2006005459A2 WO2006005459A2 (en) 2006-01-19
WO2006005459A3 true WO2006005459A3 (en) 2006-06-08

Family

ID=35432524

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/007144 WO2006005459A2 (en) 2004-07-15 2005-07-02 Diagnostics and therapeutics for diseases associated with thyrotropin-releasing hormone degrading ectoenzyme (trhde)

Country Status (1)

Country Link
WO (1) WO2006005459A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE20060253A1 (en) * 2006-03-31 2007-11-14 Trinity College Dublin Methods for modulating the levels and effects of thyrotropin-releasing hormone(trh)and trh-related peptides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030092113A1 (en) * 1999-12-09 2003-05-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030166944A1 (en) * 2000-02-17 2003-09-04 The Provost, Fellows And Scholars Of The College Of Th Holy TRH-like peptide derivatives as inhibitors of the TRH-degrading ectoenzyme

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030092113A1 (en) * 1999-12-09 2003-05-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030166944A1 (en) * 2000-02-17 2003-09-04 The Provost, Fellows And Scholars Of The College Of Th Holy TRH-like peptide derivatives as inhibitors of the TRH-degrading ectoenzyme

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CUMMINS P M ET AL: "Pyroglutamyl peptidase: an overview of the three known enzymatic forms", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 1429, no. 1, 8 December 1998 (1998-12-08), pages 1 - 17, XP004278561, ISSN: 0167-4838 *
EHRCHEN JAN ET AL: "Analysis of thyrotropin-releasing hormone-signaling components in pituitary adenomas of patients with acromegaly", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 85, no. 8, August 2000 (2000-08-01), pages 2709 - 2713, XP002358530, ISSN: 0021-972X *

Also Published As

Publication number Publication date
WO2006005459A2 (en) 2006-01-19

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