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WO2006005268A3 - Composición farmacéutica conteniendo fragmentos polipéptidicos de serralisinas - Google Patents

Composición farmacéutica conteniendo fragmentos polipéptidicos de serralisinas Download PDF

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Publication number
WO2006005268A3
WO2006005268A3 PCT/CU2005/000003 CU2005000003W WO2006005268A3 WO 2006005268 A3 WO2006005268 A3 WO 2006005268A3 CU 2005000003 W CU2005000003 W CU 2005000003W WO 2006005268 A3 WO2006005268 A3 WO 2006005268A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
serralysins
polypeptide fragments
pharmaceutical composition
composition containing
Prior art date
Application number
PCT/CU2005/000003
Other languages
English (en)
French (fr)
Other versions
WO2006005268A2 (es
Inventor
Perez Maria Del Car Abrahantes
Gonzalez Jesus Reyes
Rios Gloria Veliz
Diaz Eduardo Martinez
Gonzalez Caridad Anais Gasmuri
Suarez Jose Garcia
Romero Monica Bequet
Lopez Luis Javier Gonzalez
Serra Lila Rosa Castellanos
Sosa Manuel Selman-Housein
Riera Raul Gomez
Cowley Jorge Victor Gavilondo
Original Assignee
Ct Ingenieria Genetica Biotech
Perez Maria Del Car Abrahantes
Gonzalez Jesus Reyes
Rios Gloria Veliz
Diaz Eduardo Martinez
Gonzalez Caridad Anais Gasmuri
Suarez Jose Garcia
Romero Monica Bequet
Lopez Luis Javier Gonzalez
Serra Lila Rosa Castellanos
Sosa Manuel Selman-Housein
Riera Raul Gomez
Cowley Jorge Victor Gavilondo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES05762122T priority Critical patent/ES2389126T3/es
Priority to JP2007519599A priority patent/JP4914350B2/ja
Priority to RS20120391A priority patent/RS52448B/en
Priority to SI200531578T priority patent/SI1787653T1/sl
Priority to AU2005262159A priority patent/AU2005262159B2/en
Priority to KR1020077002589A priority patent/KR101365056B1/ko
Priority to PL05762122T priority patent/PL1787653T3/pl
Priority to BRPI0513136-7A priority patent/BRPI0513136A/pt
Priority to MX2007000339A priority patent/MX2007000339A/es
Priority to DK05762122.9T priority patent/DK1787653T3/da
Application filed by Ct Ingenieria Genetica Biotech, Perez Maria Del Car Abrahantes, Gonzalez Jesus Reyes, Rios Gloria Veliz, Diaz Eduardo Martinez, Gonzalez Caridad Anais Gasmuri, Suarez Jose Garcia, Romero Monica Bequet, Lopez Luis Javier Gonzalez, Serra Lila Rosa Castellanos, Sosa Manuel Selman-Housein, Riera Raul Gomez, Cowley Jorge Victor Gavilondo filed Critical Ct Ingenieria Genetica Biotech
Priority to EP05762122A priority patent/EP1787653B1/en
Priority to US11/631,880 priority patent/US8076297B2/en
Priority to CA2572984A priority patent/CA2572984C/en
Publication of WO2006005268A2 publication Critical patent/WO2006005268A2/es
Publication of WO2006005268A3 publication Critical patent/WO2006005268A3/es
Priority to HRP20120682TT priority patent/HRP20120682T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/265—Enterobacter (G)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención está relacionada con una composición capaz de inhibir el crecimiento de células tumorales de diferentes orígenes histológicos y de células endoteliales activadas. Los componentes de dicha composición son fragmentos polipeptídicos de Serralisinas, correspondientes al fragmento C-terminal, a partir de la metionina interna de la secuencia hasta el final de la molécula, los cuales pueden combinarse entre ellos y opcionalmente con prodigiosinas que potencian el efecto anti-tumoral de la composición. Las prodigiosinas en la composición pueden estar a una concentración de 0.1 - 100 nM. La acción anti-proliferativa de la composición está mediada por mecanismos apoptóticos. Su administración 'in vivo' tiene efecto antitumoral, antiangiogénico y protector contra tumores malignos.
PCT/CU2005/000003 2004-07-08 2005-07-05 Composición farmacéutica conteniendo fragmentos polipéptidicos de serralisinas WO2006005268A2 (es)

Priority Applications (14)

Application Number Priority Date Filing Date Title
MX2007000339A MX2007000339A (es) 2004-07-08 2005-07-05 Composicion farmaceutica conteniendo fragmentos polipeptidicos de serralisinas.
RS20120391A RS52448B (en) 2004-07-08 2005-07-05 ANTITUMOR PHARMACEUTICAL COMPOSITION CONTAINING SERALIZIN POLYPEPTIDE FRAGMENTS
SI200531578T SI1787653T1 (sl) 2004-07-08 2005-07-05 Protitumorski farmacevtski sestavek, ki vsebuje polipeptidne fragmente seralizinov
AU2005262159A AU2005262159B2 (en) 2004-07-08 2005-07-05 Pharmaceutical composition containing polypeptide fragments of serralysins
KR1020077002589A KR101365056B1 (ko) 2004-07-08 2005-07-05 세라리신의 폴리펩티드 분획을 포함하는 약학적 조성물
PL05762122T PL1787653T3 (pl) 2004-07-08 2005-07-05 Przeciwnowotworowa kompozycja farmaceutyczna zawierająca fragmenty polipeptydowe serralizyn
BRPI0513136-7A BRPI0513136A (pt) 2004-07-08 2005-07-05 composição farmacêutica contendo fragmentos de polipeptìdeo das serralisinas
ES05762122T ES2389126T3 (es) 2004-07-08 2005-07-05 Composición farmacéutica antitumoral que contiene fragmentos polipeptídicos de serralisinas
JP2007519599A JP4914350B2 (ja) 2004-07-08 2005-07-05 セラリシン（Ｓｅｒｒａｌｉｓｉｎｓ）のポリペプチド断片を含む医薬組成物
DK05762122.9T DK1787653T3 (da) 2004-07-08 2005-07-05 Antitumoral farmaceutisk sammensætning indeholdende polypeptidfragmenter af serralysiner
EP05762122A EP1787653B1 (en) 2004-07-08 2005-07-05 Antitumoral pharmaceutical composition containing polypeptide fragments of serralysins
US11/631,880 US8076297B2 (en) 2004-07-08 2005-07-05 Pharmaceutical composition containing polypeptide fragments of serralysins
CA2572984A CA2572984C (en) 2004-07-08 2005-07-05 A pharmaceutical composition containing polypeptide fragments of the serralysins
HRP20120682TT HRP20120682T1 (hr) 2004-07-08 2012-08-27 Protutumorski farmaceutski sastav koji sadr“i polipeptidne fragmente od seralizina

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU20040147A CU23475A1 (es) 2004-07-08 2004-07-08 Composición farmacéutica conteniendo fragmentos polipeptídicos de serralisinas
CU2004-0147 2004-07-08

Publications (2)

Publication Number Publication Date
WO2006005268A2 WO2006005268A2 (es) 2006-01-19
WO2006005268A3 true WO2006005268A3 (es) 2006-03-09

Family

ID=40259088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CU2005/000003 WO2006005268A2 (es) 2004-07-08 2005-07-05 Composición farmacéutica conteniendo fragmentos polipéptidicos de serralisinas

Country Status (22)

Country Link
US (1) US8076297B2 (es)
EP (1) EP1787653B1 (es)
JP (1) JP4914350B2 (es)
KR (1) KR101365056B1 (es)
AR (1) AR050255A1 (es)
AU (1) AU2005262159B2 (es)
BR (1) BRPI0513136A (es)
CA (1) CA2572984C (es)
CU (1) CU23475A1 (es)
CY (1) CY1114201T1 (es)
DK (1) DK1787653T3 (es)
ES (1) ES2389126T3 (es)
HR (1) HRP20120682T1 (es)
MX (1) MX2007000339A (es)
MY (1) MY150858A (es)
PL (1) PL1787653T3 (es)
PT (1) PT1787653E (es)
RS (1) RS52448B (es)
RU (1) RU2396274C2 (es)
SI (1) SI1787653T1 (es)
WO (1) WO2006005268A2 (es)
ZA (1) ZA200700178B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005308830B2 (en) * 2004-11-23 2012-01-19 Zymogenetics, Inc. Purification of recombinant human factor XIII
JP5296051B2 (ja) 2007-05-04 2013-09-25 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Ｍｒコイル吸収の補正を伴うハイブリッドｍｒ／ｐｅｔ
CU23950B1 (es) * 2011-03-21 2013-10-29 Ct De Ingeniería Genética Y Biotecnología Péptidos cíclicos con actividad antineoplásica y antiangiogénica
TWI746449B (zh) * 2015-07-20 2021-11-21 美商Ａｉ治療公司 使用阿吡莫德治療癌症之方法
CN109295041A (zh) * 2018-10-10 2019-02-01 宁波希诺亚海洋生物科技有限公司 具有舍雷肽酶活性的多肽及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519021A1 (fr) * 1981-12-28 1983-07-01 Takeda Chemical Industries Ltd Procede de stabilisation de la serrapeptase, composition contenant cette serrapeptase stabilisee et preparation de cette composition
EP0226800A2 (en) * 1985-11-15 1987-07-01 Takeda Chemical Industries, Ltd. Novel recombinant gene and use thereof
WO1999015690A1 (en) * 1997-09-20 1999-04-01 Korea Institute Of Science And Technology Novel serratia marcescens strain, prodigiosin and the use of the same as an immunosuppressive
US20040185566A1 (en) * 2003-03-19 2004-09-23 Peter Salamone Polypeptides toxic to nematodes and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002511432A (ja) * 1998-04-15 2002-04-16 レキシジェン ファーマシューティカルズ コーポレイション 新脈管形成インヒビターの同時投与による抗体−サイトカイン融合タンパク質媒介性免疫応答の増強

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519021A1 (fr) * 1981-12-28 1983-07-01 Takeda Chemical Industries Ltd Procede de stabilisation de la serrapeptase, composition contenant cette serrapeptase stabilisee et preparation de cette composition
EP0226800A2 (en) * 1985-11-15 1987-07-01 Takeda Chemical Industries, Ltd. Novel recombinant gene and use thereof
WO1999015690A1 (en) * 1997-09-20 1999-04-01 Korea Institute Of Science And Technology Novel serratia marcescens strain, prodigiosin and the use of the same as an immunosuppressive
US20040185566A1 (en) * 2003-03-19 2004-09-23 Peter Salamone Polypeptides toxic to nematodes and methods of use

Also Published As

Publication number Publication date
CU23475A1 (es) 2009-12-17
RS52448B (en) 2013-02-28
SI1787653T1 (sl) 2012-10-30
BRPI0513136A (pt) 2008-04-29
RU2007104776A (ru) 2008-08-20
MX2007000339A (es) 2007-03-12
EP1787653A2 (en) 2007-05-23
PL1787653T3 (pl) 2012-11-30
PT1787653E (pt) 2012-09-06
JP2008505129A (ja) 2008-02-21
ZA200700178B (en) 2008-06-25
ES2389126T3 (es) 2012-10-23
AR050255A1 (es) 2006-10-11
RU2396274C2 (ru) 2010-08-10
US8076297B2 (en) 2011-12-13
AU2005262159A1 (en) 2006-01-19
EP1787653B1 (en) 2012-06-06
KR20070042542A (ko) 2007-04-23
CA2572984A1 (en) 2006-01-19
HRP20120682T1 (hr) 2012-09-30
CA2572984C (en) 2014-12-09
JP4914350B2 (ja) 2012-04-11
MY150858A (en) 2014-03-14
KR101365056B1 (ko) 2014-02-21
DK1787653T3 (da) 2012-09-17
CY1114201T1 (el) 2016-08-31
US20110218138A1 (en) 2011-09-08
AU2005262159B2 (en) 2011-08-18
WO2006005268A2 (es) 2006-01-19

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