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WO2003061684A3 - Tumour treatment compositions comprising hsp70 and tumour necrosis factor - Google Patents

Tumour treatment compositions comprising hsp70 and tumour necrosis factor Download PDF

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Publication number
WO2003061684A3
WO2003061684A3 PCT/EP2003/000786 EP0300786W WO03061684A3 WO 2003061684 A3 WO2003061684 A3 WO 2003061684A3 EP 0300786 W EP0300786 W EP 0300786W WO 03061684 A3 WO03061684 A3 WO 03061684A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumour
hsp70
necrosis factor
treatment compositions
tumour necrosis
Prior art date
Application number
PCT/EP2003/000786
Other languages
French (fr)
Other versions
WO2003061684A2 (en
Inventor
Claude Libert
Ben Wielockx
Molle Wim Van
Tina Mahieu
Original Assignee
Vlaams Interuniv Inst Biotech
Universitei Gent
Claude Libert
Ben Wielockx
Molle Wim Van
Tina Mahieu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Interuniv Inst Biotech, Universitei Gent, Claude Libert, Ben Wielockx, Molle Wim Van, Tina Mahieu filed Critical Vlaams Interuniv Inst Biotech
Priority to AU2003218639A priority Critical patent/AU2003218639A1/en
Publication of WO2003061684A2 publication Critical patent/WO2003061684A2/en
Publication of WO2003061684A3 publication Critical patent/WO2003061684A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a novel pharmaceutical composition comprising HSP70 and tumour necrosis factor and its use in systemic tumour treatment.
PCT/EP2003/000786 2002-01-24 2003-01-24 Tumour treatment compositions comprising hsp70 and tumour necrosis factor WO2003061684A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003218639A AU2003218639A1 (en) 2002-01-24 2003-01-24 Tumour treatment compositions comprising hsp70 and tumour necrosis factor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02075297.8 2002-01-24
EP02075297 2002-01-24

Publications (2)

Publication Number Publication Date
WO2003061684A2 WO2003061684A2 (en) 2003-07-31
WO2003061684A3 true WO2003061684A3 (en) 2004-01-15

Family

ID=27589134

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000786 WO2003061684A2 (en) 2002-01-24 2003-01-24 Tumour treatment compositions comprising hsp70 and tumour necrosis factor

Country Status (2)

Country Link
AU (1) AU2003218639A1 (en)
WO (1) WO2003061684A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008523055A (en) * 2004-12-10 2008-07-03 ゼルニケ ビジネス サポート ビー．ヴィー． Heat shock protein (HSP) and supraventricular arrhythmia
WO2009155936A1 (en) * 2008-06-26 2009-12-30 Orphazyme Aps Use of hsp70 as a regulator of enzymatic activity
BR112013013143A2 (en) 2010-11-30 2016-08-23 Orphazyme Aps compound and method of treating a lysosomal storage disease
HUE054957T2 (en) 2014-09-15 2021-10-28 Orphazyme As Arimoclomol formulation
EP3442530A1 (en) 2016-04-13 2019-02-20 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
DK3448382T3 (en) 2016-04-29 2020-12-07 Orphazyme As Arimoclomol for the treatment of glucocerebrosidase-associated disorders
WO2022106614A1 (en) 2020-11-19 2022-05-27 Orphazyme A/S Processes for preparing arimoclomol citrate and intermediates thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5961979A (en) * 1994-03-16 1999-10-05 Mount Sinai School Of Medicine Of The City University Of New York Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5961979A (en) * 1994-03-16 1999-10-05 Mount Sinai School Of Medicine Of The City University Of New York Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JAATTELA, MARJA ET AL: "Heat-shock proteins protect cells from monocyte cytotoxicity: Possible mechanism of self-protection", J. EXP. MED. (1993), 177(1), 231-6, XP002943877 *
JAATTELA, MARJA: "Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells", INT. J. CANCER (1995), 60(5), 689-93, XP008004374 *
KIM, YOUNG-MYEONG ET AL: "Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor -.alpha.-induced apoptosis by inducing heat shock protein 70 expression", J. BIOL. CHEM. (1997), 272(2), 1402-1411, XP001077875 *

Also Published As

Publication number Publication date
WO2003061684A2 (en) 2003-07-31
AU2003218639A1 (en) 2003-09-02

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