WO2006046734A1 - オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 - Google Patents

オーロラa選択的阻害作用を有する新規アミノピリジン誘導体

Info

Publication number: WO2006046734A1
Authority: WO; WIPO (PCT)
Prior art keywords: represent; hydrogen; inhibitory effect; anticancer agent; same
Prior art date: 2004-10-29

Application number

PCT/JP2005/019957

Other languages

English (en)

French (fr)

Other versions

WO2006046734A3 (ja

WO2006046734A2 (ja

Inventor

Mitsuru Ohkubo

Tetsuya Kato

Nobuhiko Kawanishi

Takashi Mita

Toshiyasu Shimomura

Original Assignee

Banyu Pharmaceutical Co., Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-29

Filing date

2005-10-25

Publication date

2006-05-04

2005-10-25 Application filed by Banyu Pharmaceutical Co., Ltd. filed Critical Banyu Pharmaceutical Co., Ltd.

2005-10-25 Priority to EP05799135.8A priority Critical patent/EP1813609B1/en

2005-10-25 Priority to AU2005297848A priority patent/AU2005297848B2/en

2005-10-25 Priority to CA2585638A priority patent/CA2585638C/en

2005-10-25 Priority to JP2006542361A priority patent/JP4973190B2/ja

2005-10-25 Priority to US11/666,531 priority patent/US20080027042A1/en

2006-05-04 Publication of WO2006046734A1 publication Critical patent/WO2006046734A1/ja

2006-05-04 Publication of WO2006046734A2 publication Critical patent/WO2006046734A2/ja

2006-05-30 Priority to PCT/JP2006/311179 priority patent/WO2006129842A1/ja

2006-09-21 Publication of WO2006046734A3 publication Critical patent/WO2006046734A3/ja

Links

150000003927 aminopyridines Chemical class 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
229940124639 Selective inhibitor Drugs 0.000 abstract 1
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

PCT/JP2005/019957 2004-10-29 2005-10-25 オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 WO2006046734A2 (ja)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
EP05799135.8A EP1813609B1 (en)	2004-10-29	2005-10-25	Novel aminopyridine derivatives having selective aurora-a inhibitory effect
AU2005297848A AU2005297848B2 (en)	2004-10-29	2005-10-25	Novel aminopyridine derivatives having selective Aurora-A inhibitory effect
CA2585638A CA2585638C (en)	2004-10-29	2005-10-25	Aminopyridine derivatives having aurora a selective inhibitory action
JP2006542361A JP4973190B2 (ja)	2004-10-29	2005-10-25	オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
US11/666,531 US20080027042A1 (en)	2004-10-29	2005-10-25	Novel Aminopyridine Derivatives Having Aurora a Selective Inhibitory Action
PCT/JP2006/311179 WO2006129842A1 (ja)	2005-06-01	2006-05-30	オーロラa選択的阻害作用を有する新規アミノピリジン誘導体

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2004-315152		2004-10-29
JP2004315152		2004-10-29
JP2005-161156		2005-06-01
JP2005161156		2005-06-01

Publications (3)

Publication Number	Publication Date
WO2006046734A1 true WO2006046734A1 (ja)	2006-05-04
WO2006046734A2 WO2006046734A2 (ja)	2006-05-04
WO2006046734A3 WO2006046734A3 (ja)	2006-09-21

Family

ID=36227968

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PCT/JP2005/019957 WO2006046734A2 (ja)	2004-10-29	2005-10-25	オーロラa選択的阻害作用を有する新規アミノピリジン誘導体
PCT/JP2005/019958 WO2006046735A1 (en)	2004-10-29	2005-10-25	Novel aminopyridine derivatives having aurora a selective inhibitory action

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2005/019958 WO2006046735A1 (en)	2004-10-29	2005-10-25	Novel aminopyridine derivatives having aurora a selective inhibitory action

Country Status (19)

Country	Link
US (1)	US20080027042A1 (ja)
EP (2)	EP1828165B1 (ja)
JP (1)	JP4973190B2 (ja)
KR (1)	KR20070072562A (ja)
AR (1)	AR051467A1 (ja)
AU (1)	AU2005297848B2 (ja)
BR (1)	BRPI0518068A (ja)
CA (1)	CA2585638C (ja)
CR (1)	CR9066A (ja)
DO (1)	DOP2005000218A (ja)
EC (1)	ECSP077417A (ja)
IL (1)	IL182684A0 (ja)
MA (1)	MA29042B1 (ja)
MX (1)	MX2007005155A (ja)
NO (1)	NO20072688L (ja)
NZ (1)	NZ554441A (ja)
PE (1)	PE20060600A1 (ja)
TW (1)	TW200621759A (ja)
WO (2)	WO2006046734A2 (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7491720B2 (en) *	2004-10-29	2009-02-17	Banyu Pharmaceutical Co., Ltd.	Aminopyridine derivatives having Aurora A selective inhibitory action
WO2006129842A1 (ja) *	2005-06-01	2006-12-07	Banyu Pharmaceutical Co., Ltd.	オーロラa選択的阻害作用を有する新規アミノピリジン誘導体
EP1906948A4 (en)	2005-07-18	2010-03-17	Bipar Sciences Inc	TREATMENT OF CANCER
US8119655B2 (en)	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
AU2007244183B2 (en) *	2006-04-27	2012-05-10	Msd K.K.	Novel aminopyridine derivative having aurora-a-selective inhibitory activity
WO2007132221A1 (en) *	2006-05-12	2007-11-22	Cyclacel Limited	Combined anticancer pyrimidine-thiazole aurora kinase inhibitors
GB0609619D0 (en) *	2006-05-16	2006-06-21	Astrazeneca Ab	Combination
JP2008081492A (ja) *	2006-08-31	2008-04-10	Banyu Pharmaceut Co Ltd	オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
CA2662337A1 (en)	2006-09-05	2008-03-13	Bipar Sciences, Inc.	Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
AU2007292387A1 (en)	2006-09-05	2008-03-13	Bipar Sciences, Inc.	Treatment of cancer
GB0619342D0 (en) *	2006-09-30	2006-11-08	Vernalis R&D Ltd	New chemical compounds
SG158147A1 (en)	2006-10-09	2010-01-29	Takeda Pharmaceutical	Kinase inhibitors
WO2008147626A2 (en) *	2007-05-24	2008-12-04	Vertex Pharmaceuticals Incorporated	Thiazoles and pyrazoles useful as kinase inhibitors
WO2009064738A2 (en)	2007-11-12	2009-05-22	Bipar Sciences, Inc.	Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents
US20090270418A1 (en) *	2008-01-09	2009-10-29	Marianne Sloss	Pyrazole pyrazine amine compounds as kinase inhibitors, compositions thereof and methods of treatment therewith
JP5411152B2 (ja) *	2008-02-22	2014-02-12	Ｍｓｄ株式会社	オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
JP5683462B2 (ja) *	2008-07-24	2015-03-11	ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ	オーロラキナーゼ阻害剤および抗増殖剤を含む治療用組み合わせ
US8273900B2 (en)	2008-08-07	2012-09-25	Novartis Ag	Organic compounds
KR20110131302A (ko)	2009-03-23	2011-12-06	엠에스디 가부시키가이샤	오로라 ａ 선택적 억제 작용을 갖는 신규한 아미노피리딘 유도체
SG178867A1 (en)	2009-08-24	2012-04-27	Neuralstem Inc	Synthesis of a neurostimulative piperazine
TWI485146B (zh) *	2012-02-29	2015-05-21	Taiho Pharmaceutical Co Ltd	Novel piperidine compounds or salts thereof
TWI693218B (zh) *	2014-11-14	2020-05-11	美商美國禮來大藥廠	極光ａ激酶抑制劑

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6716575B2 (en) *	1995-12-18	2004-04-06	Sugen, Inc.	Diagnosis and treatment of AUR1 and/or AUR2 related disorders
JP3892296B2 (ja) *	1999-09-10	2007-03-14	メルクエンドカムパニーインコーポレーテッド	チロシンキナーゼ阻害薬
US20020065270A1 (en) *	1999-12-28	2002-05-30	Moriarty Kevin Joseph	N-heterocyclic inhibitors of TNF-alpha expression
EP1355905B1 (en) *	2000-12-21	2007-02-21	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
EA012112B1 (ru) *	2004-05-14	2009-08-28	Миллениум Фармасьютикалз, Инк.	Соединения и способы для ингибирования митотической прогрессии
EP1754706A4 (en) *	2004-05-21	2010-08-18	Banyu Pharma Co Ltd	SELECTIVE INHIBITORS FOR CDK4 AND CDK6 WITH AMINOTHIAZOLSKELETT
US7491720B2 (en) *	2004-10-29	2009-02-17	Banyu Pharmaceutical Co., Ltd.	Aminopyridine derivatives having Aurora A selective inhibitory action

2005
- 2005-10-25 TW TW094137395A patent/TW200621759A/zh unknown
- 2005-10-25 MX MX2007005155A patent/MX2007005155A/es unknown
- 2005-10-25 JP JP2006542361A patent/JP4973190B2/ja active Active
- 2005-10-25 DO DO2005000218A patent/DOP2005000218A/es unknown
- 2005-10-25 BR BRPI0518068-6A patent/BRPI0518068A/pt not_active Application Discontinuation
- 2005-10-25 AU AU2005297848A patent/AU2005297848B2/en not_active Ceased
- 2005-10-25 KR KR1020077009868A patent/KR20070072562A/ko not_active Withdrawn
- 2005-10-25 PE PE2005001248A patent/PE20060600A1/es not_active Application Discontinuation
- 2005-10-25 US US11/666,531 patent/US20080027042A1/en not_active Abandoned
- 2005-10-25 CA CA2585638A patent/CA2585638C/en not_active Expired - Fee Related
- 2005-10-25 AR ARP050104465A patent/AR051467A1/es not_active Application Discontinuation
- 2005-10-25 WO PCT/JP2005/019957 patent/WO2006046734A2/ja active Application Filing
- 2005-10-25 WO PCT/JP2005/019958 patent/WO2006046735A1/en active Application Filing
- 2005-10-25 EP EP05799006A patent/EP1828165B1/en active Active
- 2005-10-25 EP EP05799135.8A patent/EP1813609B1/en active Active
- 2005-10-25 NZ NZ554441A patent/NZ554441A/en unknown
2007
- 2007-04-19 IL IL182684A patent/IL182684A0/en unknown
- 2007-04-19 CR CR9066A patent/CR9066A/es not_active Application Discontinuation
- 2007-04-25 EC EC2007007417A patent/ECSP077417A/es unknown
- 2007-05-25 NO NO20072688A patent/NO20072688L/no not_active Application Discontinuation
- 2007-05-28 MA MA29945A patent/MA29042B1/fr unknown

Publication	Publication Date	Title
WO2006046734A3 (ja)	2006-09-21	オーロラa選択的阻害作用を有する新規アミノピリジン誘導体
WO2006046734A1 (ja)	2006-05-04	オーロラa選択的阻害作用を有する新規アミノピリジン誘導体
EP1889842A4 (en)	2009-07-29	HETEROCYCLIC CONNECTION
WO2005110410A3 (en)	2007-03-29	Kinase inhibitors as therapeutic agents
WO2007056159A3 (en)	2008-10-16	Hydrazone derivatives and uses thereof
WO2007148185A3 (en)	2008-03-13	Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors
WO2009016460A3 (en)	2009-03-26	Pyrazole compounds and their use as raf inhibitors
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WO2005074603A3 (en)	2006-11-09	Aminobenzoxazoles as therapeutic agents
WO2007048064A3 (en)	2007-06-21	Amino-pyrimidines as casein kinase ii (ck2) modulators
NO20082389L (no)	2008-08-18	2,3,4-trifenylimidazolinderivater som inhibitor av interaksjonen mellom P53- og MDM2-proteiner for anvendelse som antikreftmidler
IL174665A0 (en)	2006-08-20	Heterocyclic compounds which act as p-glycoprotein inhibitors and pharmaceutical compositions containing the same
WO2007014054A3 (en)	2007-11-15	Benzenesulfonamide inhibitor of ccr2 chemokine receptor
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