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WO2007014054A3 - Benzenesulfonamide inhibitor of ccr2 chemokine receptor - Google Patents

Benzenesulfonamide inhibitor of ccr2 chemokine receptor Download PDF

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Publication number
WO2007014054A3
WO2007014054A3 PCT/US2006/028419 US2006028419W WO2007014054A3 WO 2007014054 A3 WO2007014054 A3 WO 2007014054A3 US 2006028419 W US2006028419 W US 2006028419W WO 2007014054 A3 WO2007014054 A3 WO 2007014054A3
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WO
WIPO (PCT)
Prior art keywords
benzenesulfonamide
inhibitor
chemokine receptor
ccr2 chemokine
ccr2
Prior art date
Application number
PCT/US2006/028419
Other languages
French (fr)
Other versions
WO2007014054A2 (en
Inventor
Carl Brooks
Pamela A Cleary
Krista B Goodman
Simon Peace
Joanne Philp
Clark A Sehon
Christian Smethurst
Stephen Paul Watson
Original Assignee
Glaxo Group Limted
Carl Brooks
Pamela A Cleary
Krista B Goodman
Simon Peace
Joanne Philp
Clark A Sehon
Christian Smethurst
Stephen Paul Watson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0515194A external-priority patent/GB0515194D0/en
Priority claimed from GB0519492A external-priority patent/GB0519492D0/en
Application filed by Glaxo Group Limted, Carl Brooks, Pamela A Cleary, Krista B Goodman, Simon Peace, Joanne Philp, Clark A Sehon, Christian Smethurst, Stephen Paul Watson filed Critical Glaxo Group Limted
Publication of WO2007014054A2 publication Critical patent/WO2007014054A2/en
Publication of WO2007014054A3 publication Critical patent/WO2007014054A3/en

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    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a combination thereof, as well as compositions of methods of use of the compound, wherein R1, R2, R3, and m are described herein.
PCT/US2006/028419 2005-07-22 2006-07-21 Benzenesulfonamide inhibitor of ccr2 chemokine receptor WO2007014054A2 (en)

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US7622583B2 (en) 2005-01-14 2009-11-24 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
US7718683B2 (en) 2006-07-14 2010-05-18 Chemocentryx, Inc. Triazolyl phenyl benzenesulfonamides
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