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WO2006042327A3 - Aprotinine de recombinaison d'origine vegetale et variants d'aprotinine - Google Patents

Aprotinine de recombinaison d'origine vegetale et variants d'aprotinine Download PDF

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Publication number
WO2006042327A3
WO2006042327A3 PCT/US2005/037097 US2005037097W WO2006042327A3 WO 2006042327 A3 WO2006042327 A3 WO 2006042327A3 US 2005037097 W US2005037097 W US 2005037097W WO 2006042327 A3 WO2006042327 A3 WO 2006042327A3
Authority
WO
WIPO (PCT)
Prior art keywords
aprotinin
variants
plant
produced recombinant
immunological
Prior art date
Application number
PCT/US2005/037097
Other languages
English (en)
Other versions
WO2006042327A2 (fr
Inventor
Fakhrieh S Vojdani
Kenneth E Palmer
Stephen J Garger
Gregory P Pogue
Original Assignee
Large Scale Biology Corp
Fakhrieh S Vojdani
Kenneth E Palmer
Stephen J Garger
Gregory P Pogue
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Large Scale Biology Corp, Fakhrieh S Vojdani, Kenneth E Palmer, Stephen J Garger, Gregory P Pogue filed Critical Large Scale Biology Corp
Publication of WO2006042327A2 publication Critical patent/WO2006042327A2/fr
Publication of WO2006042327A3 publication Critical patent/WO2006042327A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne l'aprotinine native d'origine végétale et des variants d'aprotinine possédant des propriétés inhibitrices enzymatiques, immunologiques et pharmacocinétiques, ainsi que leur préparation. Dans un procédé préféré, un phytovirus à ARN de recombinaison est utilisé pour exprimer l'aprotinine + des variants de celle-ci dans des plantes Nicotiana.
PCT/US2005/037097 2004-10-12 2005-10-12 Aprotinine de recombinaison d'origine vegetale et variants d'aprotinine WO2006042327A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61848504P 2004-10-12 2004-10-12
US60/618,485 2004-10-12
US63521404P 2004-12-10 2004-12-10
US60/635,214 2004-12-10

Publications (2)

Publication Number Publication Date
WO2006042327A2 WO2006042327A2 (fr) 2006-04-20
WO2006042327A3 true WO2006042327A3 (fr) 2009-04-16

Family

ID=36149040

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/037097 WO2006042327A2 (fr) 2004-10-12 2005-10-12 Aprotinine de recombinaison d'origine vegetale et variants d'aprotinine

Country Status (1)

Country Link
WO (1) WO2006042327A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014097733A1 (fr) * 2012-12-21 2014-06-26 株式会社ＵｎｉＢｉｏ Procédé de fabrication de facteur de croissance de cellules épidermiques humain
PL434960A1 (pl) * 2020-08-13 2022-02-14 Pharmfactor Spółka Z Ograniczoną Odpowiedzialnością Sposób otrzymywania aprotyniny oraz produkt otrzymany tym sposobem

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824870A (en) * 1995-11-06 1998-10-20 Baszczynski; Chris Commercial production of aprotinin in plants
US6482798B2 (en) * 1996-07-25 2002-11-19 Bayer Aktiengesellschaft Aprotinin variants having improved properties
US20040106198A1 (en) * 2002-07-16 2004-06-03 Large Scale Biology Corporation Inhibition of peptide cleavage in plants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824870A (en) * 1995-11-06 1998-10-20 Baszczynski; Chris Commercial production of aprotinin in plants
US6482798B2 (en) * 1996-07-25 2002-11-19 Bayer Aktiengesellschaft Aprotinin variants having improved properties
US20040106198A1 (en) * 2002-07-16 2004-06-03 Large Scale Biology Corporation Inhibition of peptide cleavage in plants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CONCETTI ET AL.: "Selective Oxidation of Methionine Residues in Kunitz-Type protease inhibitors", BIOL. CHEM. HOPPE-SEYLER., vol. 370, July 1989 (1989-07-01), pages 723 - 728 *

Also Published As

Publication number Publication date
WO2006042327A2 (fr) 2006-04-20

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