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WO2004037997A3 - Fragments and activity of rel protein in m. tuberculosis adn other uses thereof - Google Patents

Fragments and activity of rel protein in m. tuberculosis adn other uses thereof Download PDF

Info

Publication number
WO2004037997A3
WO2004037997A3 PCT/US2003/033692 US0333692W WO2004037997A3 WO 2004037997 A3 WO2004037997 A3 WO 2004037997A3 US 0333692 W US0333692 W US 0333692W WO 2004037997 A3 WO2004037997 A3 WO 2004037997A3
Authority
WO
WIPO (PCT)
Prior art keywords
tuberculosis
present
adn
fragments
activity
Prior art date
Application number
PCT/US2003/033692
Other languages
French (fr)
Other versions
WO2004037997A2 (en
Inventor
David Howard Avarbock
Harvey Rubin
Andrew Brian Avarbock
Original Assignee
Univ Pennsylvania
David Howard Avarbock
Harvey Rubin
Andrew Brian Avarbock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, David Howard Avarbock, Harvey Rubin, Andrew Brian Avarbock filed Critical Univ Pennsylvania
Priority to AU2003294235A priority Critical patent/AU2003294235A1/en
Publication of WO2004037997A2 publication Critical patent/WO2004037997A2/en
Publication of WO2004037997A3 publication Critical patent/WO2004037997A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to mycobacteria. The present invention further relates to M. tuberculosis. The present invention further relates to the RelMtb. The present invention also relates to identifying new antibacterial targets and agents to inhibit mycobacterial growth. The present invention also relates to polynucleotides of RelMtb, Polypeptides of RelMtb, and antibodies that bind RelMtb and methods of using the same.
PCT/US2003/033692 2002-10-22 2003-10-22 Fragments and activity of rel protein in m. tuberculosis adn other uses thereof WO2004037997A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003294235A AU2003294235A1 (en) 2002-10-22 2003-10-22 Fragments and activity of rel protein in m. tuberculosis adn other uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42013102P 2002-10-22 2002-10-22
US60/420,129 2002-10-22

Publications (2)

Publication Number Publication Date
WO2004037997A2 WO2004037997A2 (en) 2004-05-06
WO2004037997A3 true WO2004037997A3 (en) 2004-11-18

Family

ID=32176517

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2003/033692 WO2004037997A2 (en) 2002-10-22 2003-10-22 Fragments and activity of rel protein in m. tuberculosis adn other uses thereof
PCT/US2003/033524 WO2004037192A2 (en) 2002-10-22 2003-10-22 Identification of antimycobacterial targets and the inhibition thereof as a treatment for infectious diseases

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033524 WO2004037192A2 (en) 2002-10-22 2003-10-22 Identification of antimycobacterial targets and the inhibition thereof as a treatment for infectious diseases

Country Status (2)

Country Link
AU (2) AU2003285946A1 (en)
WO (2) WO2004037997A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2246349A1 (en) * 2009-04-20 2010-11-03 BKG Pharma ApS Treatment of infectious diseases
CN102725290B (en) 2009-07-27 2016-03-09 吉利德科学股份有限公司 As the condensed heterocyclic compouds of ion channel modulators
CA2802288C (en) 2010-07-02 2018-08-21 Gilead Sciences, Inc. Triazolopyridinone compounds as ion channel modulators
MX361350B (en) 2011-05-10 2018-12-04 Gilead Sciences Inc Fused heterocyclic compounds as sodium channel modulators.
NO3175985T3 (en) 2011-07-01 2018-04-28
TWI549944B (en) 2011-07-01 2016-09-21 吉李德科學股份有限公司 Fused heterocyclic compound as ion channel regulator
WO2013043744A2 (en) 2011-09-21 2013-03-28 Inception 1, Inc. Tricyclic compounds useful as neurogenic and neuroprotective agents
CN103232447B (en) * 2013-04-02 2015-06-03 陕西科技大学 3-acetyl-5-acetylimino-2-(N-phenothiazinyl)-1,3,4-thiadiazole, and preparation method and application thereof
GB2566516A (en) 2017-09-15 2019-03-20 Univ Oxford Innovation Ltd Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria
CN109385439A (en) * 2018-09-18 2019-02-26 上海晶诺生物科技有限公司 The one recombination TM4 phage library and its application for constructing nadh dehydrogenase gene family missing mycobacterium tuberculosis
WO2023201199A2 (en) * 2022-04-11 2023-10-19 The Johns Hopkins University Tuberculosis vaccines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834279A (en) * 1996-03-07 1998-11-10 Trustees Of The University Of Pennsylvania Methods of identifying compounds that inhibit DNA synthesis in mycobacterium tuberculosis and compositions, reagents and kits for performing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834279A (en) * 1996-03-07 1998-11-10 Trustees Of The University Of Pennsylvania Methods of identifying compounds that inhibit DNA synthesis in mycobacterium tuberculosis and compositions, reagents and kits for performing the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AVARBOCK D. ET AL: "Differential Regulation of Opposing RelMtb Activities by the Aminoacylation State of a tRNA·Ribosome·mRNA·RelMtb Complex", BIOCHEMISTRY, vol. 39, no. 38, September 2000 (2000-09-01), pages 11640 - 11648, XP002981909 *
PRIMM T.P. ET AL: "The Stringent Response of Mycobacterium tuberculosis Is Required for Long-Term Survival", J. OF BACTERIOLOGY, vol. 182, no. 17, September 2000 (2000-09-01), pages 4889 - 4898, XP002981910 *

Also Published As

Publication number Publication date
AU2003294235A1 (en) 2004-05-13
WO2004037997A2 (en) 2004-05-06
AU2003294235A8 (en) 2004-05-13
WO2004037192A3 (en) 2006-09-14
AU2003285946A1 (en) 2004-05-13
AU2003285946A8 (en) 2004-05-13
WO2004037192A2 (en) 2004-05-06

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