WO2004060267A3 - A process for producing enriched fractions containing up to 100% of bacoside a and bacoside b - Google Patents
A process for producing enriched fractions containing up to 100% of bacoside a and bacoside b Download PDFInfo
- Publication number
- WO2004060267A3 WO2004060267A3 PCT/IN2003/000002 IN0300002W WO2004060267A3 WO 2004060267 A3 WO2004060267 A3 WO 2004060267A3 IN 0300002 W IN0300002 W IN 0300002W WO 2004060267 A3 WO2004060267 A3 WO 2004060267A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bacoside
- therefrom
- fractions containing
- washed
- solvent
- Prior art date
Links
- 229930193652 Bacoside Natural products 0.000 title abstract 3
- LKCTWIIDXXXXAR-CYGHALRTSA-N Bacoside a Chemical compound CC(C)=CCC[C@](C)(O)[C@@H]1[C@H]2CC[C@H]3[C@@](C)(CC[C@H]4C(C)(C)C(CC[C@]34CO)O[C@@H]3O[C@H](CO)[C@@H](O[C@@H]4OC[C@H](O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@]2(C)CC1=O LKCTWIIDXXXXAR-CYGHALRTSA-N 0.000 title abstract 2
- 239000000463 material Substances 0.000 abstract 3
- GKLLCNWAEBKYGL-UHFFFAOYSA-N Bacoside B Natural products CC(=CCC(C)(O)C1C2CCC3C(C)(CCC4C(C)(C)C(CCC34CO)OC5C(O)C(O)C(OCC6OCC(O)C(O)C6O)OC5CO)C2(C)CC1=O)C GKLLCNWAEBKYGL-UHFFFAOYSA-N 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 240000002999 Bacopa monnieri Species 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 238000013375 chromatographic separation Methods 0.000 abstract 1
- 238000011097 chromatography purification Methods 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000003495 polar organic solvent Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003809 water extraction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to extraction concentration and separation of fractions containing Bacosides A and B from plant materials of Bacopa species. The dried plant materials are subjected to alcoholic or hydroalcoholic or water extraction and concentration of the extract. This solid mass is washed with a nonpolar organic solvent to remove fatty materials therefrom. The solid obtained thereafter is extracted with an organic polar solvent, the solvent extract is washed with water to remove water soluble contaminants therefrom and then dried in vacuum. This factor which is enriched with Bacosides A and B is subjected repeated chromatographic separation and purification to obtain Bacoside A and Bacoside B therefrom.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003201756A AU2003201756A1 (en) | 2003-01-03 | 2003-01-03 | A process for producing enriched fractions containing up to 100% of bacoside a and bacoside b |
| PCT/IN2003/000002 WO2004060267A2 (en) | 2003-01-03 | 2003-01-03 | A process for producing enriched fractions containing up to 100% of bacoside a and bacoside b |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2003/000002 WO2004060267A2 (en) | 2003-01-03 | 2003-01-03 | A process for producing enriched fractions containing up to 100% of bacoside a and bacoside b |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2004060267A2 WO2004060267A2 (en) | 2004-07-22 |
| WO2004060267A3 true WO2004060267A3 (en) | 2004-11-04 |
Family
ID=32697207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2003/000002 WO2004060267A2 (en) | 2003-01-03 | 2003-01-03 | A process for producing enriched fractions containing up to 100% of bacoside a and bacoside b |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003201756A1 (en) |
| WO (1) | WO2004060267A2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1833692B (en) * | 2005-03-15 | 2010-08-11 | 成都华高药业有限公司 | False portulaca oleracea extracts, its prepn. and usage |
| US8541381B2 (en) | 2005-05-03 | 2013-09-24 | Laila Impex | Process for producing enriched fractions containing up to 100% of bacopasaponins from the plant materials of bacopa species |
| CN111067965B (en) * | 2019-12-29 | 2021-10-01 | 三原润禾生物科技有限公司 | Preparation method of bacopa monnieri saponin |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999040897A1 (en) * | 1998-02-12 | 1999-08-19 | Sederma S.A. | Composition for cosmetic or dermopharmaceutical use containing a plant extract obtained from bacopa monnieri (l.) |
| US6361804B2 (en) * | 1996-12-28 | 2002-03-26 | Shyam B. Singh-Verma | Cosmetic formulations containing extracts from Phyllanthus emblica and Centella asiatica and/or Bacopa monnieri |
-
2003
- 2003-01-03 WO PCT/IN2003/000002 patent/WO2004060267A2/en not_active Application Discontinuation
- 2003-01-03 AU AU2003201756A patent/AU2003201756A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6361804B2 (en) * | 1996-12-28 | 2002-03-26 | Shyam B. Singh-Verma | Cosmetic formulations containing extracts from Phyllanthus emblica and Centella asiatica and/or Bacopa monnieri |
| WO1999040897A1 (en) * | 1998-02-12 | 1999-08-19 | Sederma S.A. | Composition for cosmetic or dermopharmaceutical use containing a plant extract obtained from bacopa monnieri (l.) |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003201756A8 (en) | 2004-07-29 |
| AU2003201756A1 (en) | 2004-07-29 |
| WO2004060267A2 (en) | 2004-07-22 |
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