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WO2003038396A3 - Methode de detection d'un changement de conformation macromoleculaire ou d'une information de liaison - Google Patents

Methode de detection d'un changement de conformation macromoleculaire ou d'une information de liaison Download PDF

Info

Publication number
WO2003038396A3
WO2003038396A3 PCT/US2002/032481 US0232481W WO03038396A3 WO 2003038396 A3 WO2003038396 A3 WO 2003038396A3 US 0232481 W US0232481 W US 0232481W WO 03038396 A3 WO03038396 A3 WO 03038396A3
Authority
WO
WIPO (PCT)
Prior art keywords
conformational change
active
sensor
binding information
magnetic resonance
Prior art date
Application number
PCT/US2002/032481
Other languages
English (en)
Other versions
WO2003038396A2 (fr
Inventor
Alexander Pines
David E Wemmer
Megan Spence
Seth Rubin
E Janette Ruiz
Ivan E Dimitrov
Original Assignee
Univ California
Alexander Pines
David E Wemmer
Megan Spence
Seth Rubin
E Janette Ruiz
Ivan E Dimitrov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Alexander Pines, David E Wemmer, Megan Spence, Seth Rubin, E Janette Ruiz, Ivan E Dimitrov filed Critical Univ California
Priority to AU2002356556A priority Critical patent/AU2002356556A1/en
Publication of WO2003038396A2 publication Critical patent/WO2003038396A2/fr
Publication of WO2003038396A3 publication Critical patent/WO2003038396A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Superconductor Devices And Manufacturing Methods Thereof (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Testing Or Calibration Of Command Recording Devices (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un capteur à noyau actif ou un capteur intégré fonctionnalisé à noyau actif, mis en oeuvre dans une méthode de détection d'un changement de conformation ou d'une information d'événement de liaison dans une molécule cible. Le capteur ne participe pas au changement de conformation ou à l'événement de liaison. La méthode permet de détecter directement ou indirectement l'occurrence, la délétion, le décalage, ou tout changement mesurable dans un signal de résonance magnétique présentant une propriété de résonance magnétique unique émanant du 129Xe à noyaux actifs fréquemment hyperpolarisé.
PCT/US2002/032481 2001-10-31 2002-10-09 Methode de detection d'un changement de conformation macromoleculaire ou d'une information de liaison WO2003038396A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002356556A AU2002356556A1 (en) 2001-10-31 2002-10-09 Method for detecting macromolecular conformational change and binding information

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US33517301P 2001-10-31 2001-10-31
US33524001P 2001-10-31 2001-10-31
US60/335,173 2001-10-31
US60/335,240 2001-10-31
US39904102P 2002-07-25 2002-07-25
US60/399,041 2002-07-25
US40941002P 2002-09-09 2002-09-09
US60/409,410 2002-09-09

Publications (2)

Publication Number Publication Date
WO2003038396A2 WO2003038396A2 (fr) 2003-05-08
WO2003038396A3 true WO2003038396A3 (fr) 2009-06-11

Family

ID=27502513

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2002/032471 WO2003038395A2 (fr) 2001-10-31 2002-10-09 Detection a distance par rmn/rmi de gaz polarises par laser
PCT/US2002/032481 WO2003038396A2 (fr) 2001-10-31 2002-10-09 Methode de detection d'un changement de conformation macromoleculaire ou d'une information de liaison

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2002/032471 WO2003038395A2 (fr) 2001-10-31 2002-10-09 Detection a distance par rmn/rmi de gaz polarises par laser

Country Status (4)

Country Link
EP (1) EP1590647A2 (fr)
JP (1) JP2005515406A (fr)
AU (2) AU2002356556A1 (fr)
WO (2) WO2003038395A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1555538A1 (fr) * 2004-01-15 2005-07-20 Bruker BioSpin MRI GmbH Procédé de spectroscopie rmn rapide multidimensionnelle
FR2881226B1 (fr) * 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
JP4696262B2 (ja) * 2005-05-18 2011-06-08 独立行政法人産業技術総合研究所 超偏極希ガス製造装置及び超偏極希ガスを用いた核磁気共鳴分光装置並びに磁気共鳴イメージング装置
US7359059B2 (en) * 2006-05-18 2008-04-15 Honeywell International Inc. Chip scale atomic gyroscope
JP5424578B2 (ja) * 2007-06-05 2014-02-26 キヤノン株式会社 磁気センシング方法、原子磁気センサ、及び磁気共鳴イメージング装置
JPWO2021029391A1 (fr) * 2019-08-09 2021-02-18

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426058B1 (en) * 1996-03-29 2002-07-30 The Regents Of The University Of California Enhancement of NMR and MRI in the presence of hyperpolarized noble gases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6591128B1 (en) * 2000-11-09 2003-07-08 Koninklijke Philips Electronics, N.V. MRI RF coil systems having detachable, relocatable, and or interchangeable sections and MRI imaging systems and methods employing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426058B1 (en) * 1996-03-29 2002-07-30 The Regents Of The University Of California Enhancement of NMR and MRI in the presence of hyperpolarized noble gases

Also Published As

Publication number Publication date
EP1590647A2 (fr) 2005-11-02
AU2002356556A8 (en) 2009-07-30
AU2002348428A8 (en) 2008-11-13
AU2002356556A1 (en) 2003-05-12
WO2003038395A2 (fr) 2003-05-08
JP2005515406A (ja) 2005-05-26
AU2002348428A1 (en) 2003-05-12
WO2003038395A3 (fr) 2008-10-16
WO2003038396A2 (fr) 2003-05-08
WO2003038395A8 (fr) 2004-04-29

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