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WO2003033506A1 - Derive d'acide d'aminoborane et medicament inhibiteur de proteasomes le contenant - Google Patents

Derive d'acide d'aminoborane et medicament inhibiteur de proteasomes le contenant Download PDF

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Publication number
WO2003033506A1
WO2003033506A1 PCT/JP2002/010450 JP0210450W WO03033506A1 WO 2003033506 A1 WO2003033506 A1 WO 2003033506A1 JP 0210450 W JP0210450 W JP 0210450W WO 03033506 A1 WO03033506 A1 WO 03033506A1
Authority
WO
WIPO (PCT)
Prior art keywords
aminoborane
acid derivative
same
proteasome inhibitory
remedy
Prior art date
Application number
PCT/JP2002/010450
Other languages
English (en)
Japanese (ja)
Inventor
Hiroaki Satoh
Masahiro Ueno
Yoji Tachibana
Koichi Nakamaru
Ryotaro Kojima
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Nisshin Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd., Nisshin Pharma Inc. filed Critical Kyorin Pharmaceutical Co., Ltd.
Priority to JP2003536245A priority Critical patent/JPWO2003033506A1/ja
Publication of WO2003033506A1 publication Critical patent/WO2003033506A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un nouveau dérivé d'acide d'aminoborane représenté par la formule générale (1) (où x représente un groupe de formule générale (2), (3) ou (4) ; Y représente le groupe de formule (5) ou (6) ; R1 et R2 sont identiques ou différents et chacun représente alkyle C3-6 ou alkyle C1-6 substitué par du phényle ; Z-1 représente oxygène ou soufre ; Z2 représente hydrogène, méthoxy ou halogène ; et m représente 1 ou 2), qui présente une activité inhibitrice de protéasomes. Ledit composé à activité inhibitrice de protéasomes est utile en tant qu'immunosuppresseur, agent anti-inflammatoire, antiallergique, remède contre les maladies auto-immunes, remède contre les maladies inflammatoires chroniques telles que les maladies entériques inflammatoires (colite ulcéreuse et maladie de Crohn), agent anticancéreux ou remède contre les maladies de dégénérescence nerveuse.
PCT/JP2002/010450 2001-10-12 2002-10-08 Derive d'acide d'aminoborane et medicament inhibiteur de proteasomes le contenant WO2003033506A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003536245A JPWO2003033506A1 (ja) 2001-10-12 2002-10-08 アミノボラン酸誘導体およびそれを含有するプロテアソーム阻害薬

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-314731 2001-10-12
JP2001314731 2001-10-12

Publications (1)

Publication Number Publication Date
WO2003033506A1 true WO2003033506A1 (fr) 2003-04-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/010450 WO2003033506A1 (fr) 2001-10-12 2002-10-08 Derive d'acide d'aminoborane et medicament inhibiteur de proteasomes le contenant

Country Status (2)

Country Link
JP (1) JPWO2003033506A1 (fr)
WO (1) WO2003033506A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003059898A3 (fr) * 2002-01-08 2004-02-26 Eisai Co Ltd Analogues d'eponemycine et d'epoxomicine et leurs utilisations
JP2007502304A (ja) * 2003-08-14 2007-02-08 セファロン、インク． プロテアソーム阻害剤及びそれらを使用する方法
EP2088205A1 (fr) 2008-02-11 2009-08-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) PSMB10 : marqueur de diagnostic et cible thérapeutique de rejet chronique
CN102127052A (zh) * 2011-01-25 2011-07-20 浙江大学 1,4-苯并二恶烷-2-羧酸的合成方法
KR101441703B1 (ko) 2006-06-19 2014-09-17 오닉스 세라퓨틱스, 인크. 프로테아좀 저해를 위한 펩티드 에폭시케톤
US9126997B1 (en) 2010-09-07 2015-09-08 Northwestern University Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma
JP2016172768A (ja) * 2016-06-27 2016-09-29 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤
AU2016202747B2 (en) * 2004-03-30 2017-11-23 Millennium Pharmaceuticals, Inc. Synthesis of boronic ester and acid compounds
CN107474062A (zh) * 2004-03-30 2017-12-15 千禧药品公司 硼的酯和酸化合物的合成
WO2018159628A1 (fr) * 2017-02-28 2018-09-07 国立大学法人北海道大学 Acylborane de type acide aminé et procédé pour sa production
US10526351B2 (en) 2008-06-17 2020-01-07 Millennium Pharmaceuticals, Inc. Boronate ester compounds and pharmaceutical compositions thereof
JP2021526159A (ja) * 2018-05-28 2021-09-30 チャンスー チア タイ フェンハイ ファーマシューティカル カンパニー リミテッドＪｉａｎｇｓｕ Ｃｈｉａ Ｔａｉ Ｆｅｎｇｈａｉ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． ペプチドボロン酸エステル類化合物の合成及び使用
US11241448B2 (en) 2014-05-20 2022-02-08 Millennium Pharmaceuticals, Inc. Methods for cancer therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524883B2 (en) 2002-01-08 2009-04-28 Eisai R&D Management Co., Ltd. Eponemycin and epoxomicin analogs and uses thereof
WO2003059898A3 (fr) * 2002-01-08 2004-02-26 Eisai Co Ltd Analogues d'eponemycine et d'epoxomicine et leurs utilisations
JP4917431B2 (ja) * 2003-08-14 2012-04-18 セファロン、インク． プロテアソーム阻害剤及びそれらを使用する方法
JP2007502304A (ja) * 2003-08-14 2007-02-08 セファロン、インク． プロテアソーム阻害剤及びそれらを使用する方法
CN107474062A (zh) * 2004-03-30 2017-12-15 千禧药品公司 硼的酯和酸化合物的合成
AU2016202747B2 (en) * 2004-03-30 2017-11-23 Millennium Pharmaceuticals, Inc. Synthesis of boronic ester and acid compounds
KR101441703B1 (ko) 2006-06-19 2014-09-17 오닉스 세라퓨틱스, 인크. 프로테아좀 저해를 위한 펩티드 에폭시케톤
EP2088205A1 (fr) 2008-02-11 2009-08-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) PSMB10 : marqueur de diagnostic et cible thérapeutique de rejet chronique
US10604538B2 (en) 2008-06-17 2020-03-31 Millenium Pharmaceuticals, Inc. Boronate ester compounds and pharmaceutical compositions thereof
US11485746B2 (en) 2008-06-17 2022-11-01 Millennium Pharmaceuticals, Inc. Boronate ester compounds and pharmaceutical compositions thereof
US10526351B2 (en) 2008-06-17 2020-01-07 Millennium Pharmaceuticals, Inc. Boronate ester compounds and pharmaceutical compositions thereof
US9126997B1 (en) 2010-09-07 2015-09-08 Northwestern University Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma
CN102127052A (zh) * 2011-01-25 2011-07-20 浙江大学 1,4-苯并二恶烷-2-羧酸的合成方法
US11241448B2 (en) 2014-05-20 2022-02-08 Millennium Pharmaceuticals, Inc. Methods for cancer therapy
JP2016172768A (ja) * 2016-06-27 2016-09-29 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤
JPWO2018159628A1 (ja) * 2017-02-28 2019-12-26 国立大学法人北海道大学 アミノ酸型アシルボランおよびその製造方法
WO2018159628A1 (fr) * 2017-02-28 2018-09-07 国立大学法人北海道大学 Acylborane de type acide aminé et procédé pour sa production
JP7244921B2 (ja) 2017-02-28 2023-03-23 国立大学法人北海道大学 アミノ酸型アシルボランおよびその製造方法
JP2021526159A (ja) * 2018-05-28 2021-09-30 チャンスー チア タイ フェンハイ ファーマシューティカル カンパニー リミテッドＪｉａｎｇｓｕ Ｃｈｉａ Ｔａｉ Ｆｅｎｇｈａｉ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． ペプチドボロン酸エステル類化合物の合成及び使用
JP7314259B2 (ja) 2018-05-28 2023-07-25 チャンスー チア タイ フェンハイ ファーマシューティカル カンパニー リミテッド ペプチドボロン酸エステル類化合物の合成及び使用

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