WO2003032967A1 - Method of stabilizing reduced coenzyme q10 - Google Patents

Method of stabilizing reduced coenzyme q10 Download PDF

Info

Publication number: WO2003032967A1
Authority: WO; WIPO (PCT)
Prior art keywords: reduced coenzyme; derivative; coenzyme; ascorbic acid; good qualities
Prior art date: 2001-10-10

Application number

PCT/JP2002/010515

Other languages

English (en)

French (fr)

Inventor

Takahiro Ueda

Tadao Ono

Mitsutoshi Moro

Shiro Kitamura

Yasuyoshi Ueda

Original Assignee

Kaneka Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-10

Filing date

2002-10-10

Publication date

2003-04-24

2002-10-10 Application filed by Kaneka Corporation filed Critical Kaneka Corporation

2002-10-10 Priority to JP2003535771A priority Critical patent/JP3790530B2/ja

2002-10-10 Priority to EP02775311.0A priority patent/EP1452174B1/en

2002-10-10 Priority to US10/492,122 priority patent/US8703155B2/en

2002-10-10 Priority to KR1020047005199A priority patent/KR100934330B1/ko

2002-10-10 Priority to AU2002343962A priority patent/AU2002343962B2/en

2002-10-10 Priority to CA2462557A priority patent/CA2462557C/en

2003-04-24 Publication of WO2003032967A1 publication Critical patent/WO2003032967A1/ja

2014-03-05 Priority to US14/197,347 priority patent/US9532957B2/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/46—Use of additives, e.g. for stabilisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Nutrition Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

PCT/JP2002/010515 2001-10-10 2002-10-10 Method of stabilizing reduced coenzyme q10 WO2003032967A1 (en)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
JP2003535771A JP3790530B2 (ja)	2001-10-10	2002-10-10	還元型補酵素ｑ１０の安定化法
EP02775311.0A EP1452174B1 (en)	2001-10-10	2002-10-10	Stabilized composition comprising reduced coenzyme q10
US10/492,122 US8703155B2 (en)	2001-10-10	2002-10-10	Method of stabilizing reduced coenzyme q10
KR1020047005199A KR100934330B1 (ko)	2001-10-10	2002-10-10	환원형 보효소 ｑ10의 안정화법
AU2002343962A AU2002343962B2 (en)	2001-10-10	2002-10-10	Method of stabilizing reduced coenzyme Q10
CA2462557A CA2462557C (en)	2001-10-10	2002-10-10	Method of stabilizing reduced coenzyme q10
US14/197,347 US9532957B2 (en)	2001-10-10	2014-03-05	Method of stabilizing reduced coenzyme Q10

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2001312179		2001-10-10
JP2001-312179		2001-10-10
JP2002-114879		2002-04-17
JP2002114879		2002-04-17

Related Child Applications (2)

Application Number	Title	Priority Date	Filing Date
US10/492,122 A-371-Of-International US8703155B2 (en)	2001-10-10	2002-10-10	Method of stabilizing reduced coenzyme q10
US14/197,347 Division US9532957B2 (en)	2001-10-10	2014-03-05	Method of stabilizing reduced coenzyme Q10

Publications (1)

Publication Number	Publication Date
WO2003032967A1 true WO2003032967A1 (en)	2003-04-24

Family

ID=26623825

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2002/010515 WO2003032967A1 (en)	2001-10-10	2002-10-10	Method of stabilizing reduced coenzyme q10

Country Status (10)

Country	Link
US (2)	US8703155B2 (ja)
EP (3)	EP2377524A1 (ja)
JP (1)	JP3790530B2 (ja)
KR (3)	KR100959467B1 (ja)
CN (3)	CN101318889B (ja)
AU (1)	AU2002343962B2 (ja)
CA (3)	CA2781766C (ja)
DK (1)	DK2380568T3 (ja)
TW (1)	TWI329510B (ja)
WO (1)	WO2003032967A1 (ja)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPWO2003062182A1 (ja) *	2002-01-18	2005-05-19	株式会社カネカ	還元型補酵素ｑ▲下１０▼を安定化するための方法並びに組成物
WO2005089740A1 (ja) *	2004-03-23	2005-09-29	Kaneka Corporation	血中持続性補酵素ｑ組成物
JP2006083132A (ja) *	2004-09-17	2006-03-30	Kaneka Corp	還元型ビタミンｋの製造方法
WO2006075502A1 (ja) *	2004-12-24	2006-07-20	Kaneka Corporation	還元型補酵素ｑ１０を含有する固形製剤及びその製造方法
JP2007145831A (ja) *	2005-10-31	2007-06-14	Kaneka Corp	還元型補酵素ｑ１０を安定化するための方法
WO2007126083A1 (ja)	2006-04-28	2007-11-08	Kaneka Corporation	還元型補酵素ｑ10の安定化方法
WO2008029909A1 (en)	2006-09-08	2008-03-13	Kaneka Corporation	Composition comprising reduced coenzyme q10 and lysolecithin
US7358402B2 (en)	2003-09-10	2008-04-15	Kaneka Corporation	Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
US7364751B2 (en)	2001-10-10	2008-04-29	Kaneka Corporation	Stabilized compositions of aqueous reduced coenzyme Q solution
WO2008129980A1 (ja) *	2007-04-16	2008-10-30	Kaneka Corporation	還元型補酵素ｑ１０含有粒子状組成物及びその製造方法
WO2009044852A1 (ja) *	2007-10-05	2009-04-09	Kaneka Corporation	還元型補酵素ｑ１０の製造方法
WO2009057611A1 (ja) *	2007-10-30	2009-05-07	Kaneka Corporation	含水有機溶媒を用いる還元型補酵素ｑ１０の製造方法
US7708990B2 (en)	2004-03-23	2010-05-04	Kaneka Corporation	Coenzyme Q compositions persisting in blood
WO2011046199A1 (ja)	2009-10-16	2011-04-21	株式会社カネカ	還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
WO2011045934A1 (ja)	2009-10-16	2011-04-21	株式会社カネカ	還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
US8067217B2 (en)	2004-12-28	2011-11-29	Kaneka Corporation	Method for preserving reduced coenzyme Q10
WO2012176842A1 (ja)	2011-06-24	2012-12-27	株式会社カネカ	安定性に優れた還元型補酵素ｑ１０結晶
US8506956B2 (en)	2005-10-31	2013-08-13	Kaneka Corporation	Method for stabilizing reduced coenzyme Q10
CN106117033A (zh) *	2016-06-23	2016-11-16	浙江大学	一种同时分离制备高纯度辅酶q10和还原型辅酶q10的工艺
CN106146278A (zh) *	2016-06-23	2016-11-23	浙江大学	一种从菌渣中提取分离辅酶q10的工艺
JPWO2015122531A1 (ja) *	2014-02-17	2017-03-30	株式会社カネカ	還元型補酵素ｑ１０を含有する組成物

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TWI349039B (en)	2001-12-27	2011-09-21	Kaneka Corp	Processes for producing coenzyme q10
US7707039B2 (en) *	2004-02-15	2010-04-27	Exbiblio B.V.	Automatic modification of web pages
US20060147542A1 (en) *	2004-12-24	2006-07-06	Tadao Ono	Solid preparation containing reduced coenzyme Q10 and method for producing the same
WO2006104153A1 (ja) *	2005-03-29	2006-10-05	Kaneka Corporation	血液中の抗酸化活性を高める組成物
WO2007126086A1 (ja) *	2006-04-28	2007-11-08	Kaneka Corporation	還元型補酵素ｑ10の精製方法
KR100786884B1 (ko) *	2006-06-27	2007-12-20	영진약품공업주식회사	코엔자임 ｑ１０ 함유 수용성 조성물
US20100092560A1 (en) *	2007-04-16	2010-04-15	Kaneka Corporation	Reduced coenzyme q10-containing particulate composition and method for producing the same
JP5364580B2 (ja) *	2007-08-22	2013-12-11	株式会社カネカ	還元型補酵素ｑ１０の製造方法、ならびに、その安定化方法
JP2015131766A (ja)	2012-04-27	2015-07-23	株式会社カネカ	還元型補酵素ｑ１０の製造方法
WO2014188861A1 (ja)	2013-05-20	2014-11-27	ユーハ味覚糖株式会社	ユビキノール高含有ゲル状組成物
RU2535928C1 (ru) *	2013-05-31	2014-12-20	Закрытое акционерное общество "Научно-производственное объединение "ДОМ ФАРМАЦИИ"	Экспрессный способ получения восстановленной формы коэнзима q10 на основе катализаторов для использования в фармацевтических и пищевых композициях
CN106497993B (zh) *	2016-09-05	2021-07-06	广东润和生物科技有限公司	还原型辅酶q10及化妆品
CN106222209B (zh) *	2016-09-05	2020-12-29	米涛(上海)环保科技有限公司	还原型辅酶q10的生产方法
EP3755683A1 (en) *	2018-02-23	2020-12-30	Center for Intelligent Research in Crystal Engineering, S.L.	Cocrystals of ubiquinol and compositions comprising them
US11471426B2 (en)	2019-10-16	2022-10-18	American River Nutrition, Llc	Compositions comprising quinone and/or quinol and methods of preparations and use thereof
DE102019218240A1 (de) *	2019-11-26	2021-05-27	Beiersdorf Ag	Wirkstoffkombinationen aus Ubichinol und Glycerylstearatcitrat und kosmetische oder dermatologische Zubereitungen, solche Wirkstoffkombinationen enthaltend
CN113024362B (zh)	2021-03-10	2022-02-15	中国科学院上海药物研究所	一种辅酶qh与烟酰胺的共晶及其制备方法和用途

Citations (5)

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Publication number	Priority date	Publication date	Assignee	Title
WO1998007417A1 (fr) *	1996-08-16	1998-02-26	Kaneka Corporation	Compositions pharmaceutiques contenant de la coenzyme q¿10?
DE19806947A1 (de)	1998-02-19	1999-08-26	Beiersdorf Ag	Kosmetische oder dermatologische Wirkstoffkombinationen aus mindestens einer Substanz gewählt aus der Gruppe, bestehend aus Carnitin und den Acylcarnitinen, und mindestens einem Chinon und oder mindestens einem Hydrochinon sowie Zubereitungen mit einem Gehalt an solchen Wirkstoffkombinationen
WO2001052822A1 (en)	2000-01-20	2001-07-26	Chopra Raj K	Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications
WO2002090304A1 (fr) *	2001-05-09	2002-11-14	Kaneka Corporation	Solution stable de coenzyme q reduite
EP1440962A1 (en)	2001-10-10	2004-07-28	Kaneka Corporation	Stabilized compositions of aqueous reduced coenzyme q solution

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GB947643A (en) *	1959-05-25	1964-01-22	Merck & Co Inc	Substituted chroman compounds
US3066080A (en) *	1961-03-22	1962-11-27	Merck & Co Inc	Fermentation production of coenzyme q-10
US3162657A (en)	1962-07-25	1964-12-22	Armour & Co	Production of alpha-sulfoalkanoic acids
US6207137B1 (en) *	1997-06-12	2001-03-27	C.S. Bioscience, Inc.	Dental formulation
CN1092986C (zh)	1999-08-16	2002-10-23	上海本草生物医学工程研究所	一种用于降血脂的辅酶a口服制剂及制备方法和应用
US6740338B1 (en) *	2000-01-20	2004-05-25	Raj K. Chopra	Reduced form of Cenzyme Q in high bioavailability stable oral dosage form
CN1127949C (zh) *	2000-02-28	2003-11-19	康健	一种复合辅酶q10营养保健品
TWI310029B (ja)	2001-07-13	2009-05-21	Kaneka Corp
US20040197886A1 (en)	2001-07-13	2004-10-07	Takahiro Ueda	Method of crystallizing reduced coenzyme Q10 from aqueous solution
TWI237018B (en)	2001-07-13	2005-08-01	Kaneka Corp	Method of producing reduced coenzyme Q10 crystals
JP2003119127A (ja)	2001-10-10	2003-04-23	Kanegafuchi Chem Ind Co Ltd	安定な還元型補酵素ｑ製剤

2002
- 2002-10-09 TW TW091123239A patent/TWI329510B/zh not_active IP Right Cessation
- 2002-10-10 CN CN2008101361393A patent/CN101318889B/zh not_active Expired - Lifetime
- 2002-10-10 US US10/492,122 patent/US8703155B2/en not_active Expired - Lifetime
- 2002-10-10 CA CA2781766A patent/CA2781766C/en not_active Expired - Lifetime
- 2002-10-10 KR KR1020097017987A patent/KR100959467B1/ko not_active Expired - Fee Related
- 2002-10-10 EP EP11173424A patent/EP2377524A1/en not_active Withdrawn
- 2002-10-10 CA CA2462557A patent/CA2462557C/en not_active Expired - Lifetime
- 2002-10-10 CN CNB02824009XA patent/CN100415220C/zh not_active Expired - Lifetime
- 2002-10-10 EP EP02775311.0A patent/EP1452174B1/en not_active Expired - Lifetime
- 2002-10-10 EP EP11173425.7A patent/EP2380568B8/en not_active Expired - Lifetime
- 2002-10-10 JP JP2003535771A patent/JP3790530B2/ja not_active Expired - Fee Related
- 2002-10-10 DK DK11173425.7T patent/DK2380568T3/da active
- 2002-10-10 CA CA2746795A patent/CA2746795C/en not_active Expired - Lifetime
- 2002-10-10 CN CN201110217296.9A patent/CN102381948B/zh not_active Expired - Lifetime
- 2002-10-10 AU AU2002343962A patent/AU2002343962B2/en not_active Expired
- 2002-10-10 KR KR1020047005199A patent/KR100934330B1/ko not_active Expired - Fee Related
- 2002-10-10 WO PCT/JP2002/010515 patent/WO2003032967A1/ja active Application Filing
- 2002-10-10 KR KR1020097017988A patent/KR100959465B1/ko not_active Expired - Fee Related
2014
- 2014-03-05 US US14/197,347 patent/US9532957B2/en not_active Expired - Fee Related

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998007417A1 (fr) *	1996-08-16	1998-02-26	Kaneka Corporation	Compositions pharmaceutiques contenant de la coenzyme q¿10?
EP0956854A1 (en)	1996-08-16	1999-11-17	Kaneka Corporation	Pharmaceutical composition comprising coenzyme q 10
DE19806947A1 (de)	1998-02-19	1999-08-26	Beiersdorf Ag	Kosmetische oder dermatologische Wirkstoffkombinationen aus mindestens einer Substanz gewählt aus der Gruppe, bestehend aus Carnitin und den Acylcarnitinen, und mindestens einem Chinon und oder mindestens einem Hydrochinon sowie Zubereitungen mit einem Gehalt an solchen Wirkstoffkombinationen
WO2001052822A1 (en)	2000-01-20	2001-07-26	Chopra Raj K	Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications
WO2002090304A1 (fr) *	2001-05-09	2002-11-14	Kaneka Corporation	Solution stable de coenzyme q reduite
EP1440962A1 (en)	2001-10-10	2004-07-28	Kaneka Corporation	Stabilized compositions of aqueous reduced coenzyme q solution

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1452174A4 *

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7364751B2 (en)	2001-10-10	2008-04-29	Kaneka Corporation	Stabilized compositions of aqueous reduced coenzyme Q solution
JP4572073B2 (ja) *	2002-01-18	2010-10-27	株式会社カネカ	還元型補酵素ｑ１０を安定化するための方法並びに組成物
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