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WO2003015710A3 - Therapies et systemes combinant l'administration de medicament et l'extraction de liquide cephalorachidien - Google Patents

Therapies et systemes combinant l'administration de medicament et l'extraction de liquide cephalorachidien Download PDF

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Publication number
WO2003015710A3
WO2003015710A3 PCT/US2002/026435 US0226435W WO03015710A3 WO 2003015710 A3 WO2003015710 A3 WO 2003015710A3 US 0226435 W US0226435 W US 0226435W WO 03015710 A3 WO03015710 A3 WO 03015710A3
Authority
WO
WIPO (PCT)
Prior art keywords
csf
space
systems
implantable
combined drug
Prior art date
Application number
PCT/US2002/026435
Other languages
English (en)
Other versions
WO2003015710A2 (fr
Inventor
Dawn Mcguire
Tom Saul
Denise F Gottfried
Original Assignee
Eunoe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eunoe Inc filed Critical Eunoe Inc
Priority to AU2002313778A priority Critical patent/AU2002313778A1/en
Publication of WO2003015710A2 publication Critical patent/WO2003015710A2/fr
Publication of WO2003015710A3 publication Critical patent/WO2003015710A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • A61M3/0254—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped
    • A61M3/0258—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped by means of electric pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0464—Cerebrospinal fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • External Artificial Organs (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Selon l'invention, des maladies et d'autres états pathologiques du système nerveux central sont traités par administration d'un agent thérapeutique dans un espace occupé par le fluide céphalorachidien et, de manière simultanée ou séquentielle, évacuation du fluide céphalorachidien de l'espace qu'il occupe. Des systèmes prévus à cet effet comprennent au moins un cathéter implantable servant à accéder à l'espace occupé par le fluide céphalorachidien, en général un espace ventriculaire ou lombaire, ainsi qu'au moins un cathéter servant à évacuer le fluide céphalorachidien vers un autre emplacement, par exemple vers la cavité péritonéale. Des pompes implantables servent à administrer l'agent thérapeutique par l'intermédiaire du cathéter donnant accès à l'espace occupé par le fluide céphalorachidien et des mécanismes de régulation de débit implantables sont utilisés pour réguler le débit et le volume du fluide céphalorachidien évacué dudit espace.
PCT/US2002/026435 2001-08-21 2002-08-19 Therapies et systemes combinant l'administration de medicament et l'extraction de liquide cephalorachidien WO2003015710A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002313778A AU2002313778A1 (en) 2001-08-21 2002-08-19 Combined drug and csf removal therapies and systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31393801P 2001-08-21 2001-08-21
US60/313,938 2001-08-21

Publications (2)

Publication Number Publication Date
WO2003015710A2 WO2003015710A2 (fr) 2003-02-27
WO2003015710A3 true WO2003015710A3 (fr) 2004-02-12

Family

ID=23217836

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/026435 WO2003015710A2 (fr) 2001-08-21 2002-08-19 Therapies et systemes combinant l'administration de medicament et l'extraction de liquide cephalorachidien

Country Status (2)

Country Link
AU (1) AU2002313778A1 (fr)
WO (1) WO2003015710A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60134654D1 (de) 2000-09-11 2008-08-14 Csf Dynamics As Flüssigkeitsableitvorrichtung zur behandlung des hydrocephalus
ES2307396B1 (es) * 2006-09-14 2009-09-30 Fundacion Para Investigaciones Neurologicas (Fin) Sistemas de eliminacion de sustancias neurotoxicas causantes de enfermedades neurodegenerativas mediante su atrapamiento selectivo por inmunoafinidad en el liquido cefalo-raquideo circulante.
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
JP2010505556A (ja) 2006-10-09 2010-02-25 ニューロフルーディクス， インコーポレイテッド 脳脊髄液精製システム
WO2011114260A1 (fr) 2010-03-19 2011-09-22 Pfizer Inc. Système de purification de liquide céphalorachidien
US20150038948A1 (en) * 2013-07-31 2015-02-05 G-Tech Electronic Research & Development, LLC Apparatus and use of a neurochemisrty regulator device insertable in the cranium for the treatment of cerebral cortical disorders
US9421348B2 (en) 2013-10-01 2016-08-23 Ecole Polytechnique Federale De Lausanne (Epfl) Systems and methods for moving and circulating fluid to treat alzheimer's disease
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
EP3714915B1 (fr) 2015-08-05 2021-11-03 Minnetronix Inc. Système de filtration à flux tangentiel pour la filtration de matériaux provenant de fluides biologiques
ES2856599T3 (es) 2015-12-04 2021-09-27 Minnetronix Inc Sistemas de acondicionamiento de fluido cerebrospinal
CN107088257B (zh) * 2017-04-27 2023-06-09 哈尔滨医科大学 一种y型两用双腔两囊引流器
AU2019310040A1 (en) 2018-07-23 2021-02-11 Enclear Therapies, Inc. Methods of treating neurological disorders
CN113164563A (zh) 2018-07-23 2021-07-23 因柯利尔疗法公司 神经性病症的治疗方法
AU2020271894A1 (en) * 2019-04-11 2021-12-02 Enclear Therapies, Inc. Methods of amelioration of cerebrospinal fluid and devices and systems therefor
US11559626B2 (en) 2020-04-08 2023-01-24 Medtronic, Inc. Means to treat Alzheimer's disease via flushing of brain parenchyma
JP2023543868A (ja) * 2020-09-29 2023-10-18 エンクリアー セラピーズ， インク． くも膜下液管理方法およびシステム

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5957912A (en) * 1998-04-16 1999-09-28 Camino Neurocare, Inc. Catheter having distal stylet opening and connector
US6193691B1 (en) * 1999-03-30 2001-02-27 Depuy Orthopaedics, Inc. Catheter system
US6210346B1 (en) * 1989-10-11 2001-04-03 Edwards Lifesciences Corp. Method for inserting an intracranial catheter and for monitoring intracranial pressure in a mammal
US20030135148A1 (en) * 2002-01-14 2003-07-17 Dextradeur Alan J. Multi-catheter insertion device and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210346B1 (en) * 1989-10-11 2001-04-03 Edwards Lifesciences Corp. Method for inserting an intracranial catheter and for monitoring intracranial pressure in a mammal
US5957912A (en) * 1998-04-16 1999-09-28 Camino Neurocare, Inc. Catheter having distal stylet opening and connector
US6193691B1 (en) * 1999-03-30 2001-02-27 Depuy Orthopaedics, Inc. Catheter system
US20030135148A1 (en) * 2002-01-14 2003-07-17 Dextradeur Alan J. Multi-catheter insertion device and method

Also Published As

Publication number Publication date
WO2003015710A2 (fr) 2003-02-27
AU2002313778A1 (en) 2003-03-03

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