+

WO2003015710A3 - Combined drug and csf removal therapies and systems - Google Patents

Combined drug and csf removal therapies and systems Download PDF

Info

Publication number
WO2003015710A3
WO2003015710A3 PCT/US2002/026435 US0226435W WO03015710A3 WO 2003015710 A3 WO2003015710 A3 WO 2003015710A3 US 0226435 W US0226435 W US 0226435W WO 03015710 A3 WO03015710 A3 WO 03015710A3
Authority
WO
WIPO (PCT)
Prior art keywords
csf
space
systems
implantable
combined drug
Prior art date
Application number
PCT/US2002/026435
Other languages
French (fr)
Other versions
WO2003015710A2 (en
Inventor
Dawn Mcguire
Tom Saul
Denise F Gottfried
Original Assignee
Eunoe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eunoe Inc filed Critical Eunoe Inc
Priority to AU2002313778A priority Critical patent/AU2002313778A1/en
Publication of WO2003015710A2 publication Critical patent/WO2003015710A2/en
Publication of WO2003015710A3 publication Critical patent/WO2003015710A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • A61M3/0254—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped
    • A61M3/0258—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped by means of electric pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0464—Cerebrospinal fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • External Artificial Organs (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Diseases and other conditions of the central nervous system are treated by concurrently or sequentially delivering a therapeutic agent to a cerebrospinal fluid (CSF) space and draining CSF from the CSF space. Systems (70) include one or more implantable catheters (52, 60, 66)for accessing the CSF space, typically in a ventricle or lumbar space, in one catheters for draining the CSF to another location, such as the peritoneal cavity. Implantable pumps (54) provided for delivering the therapeutic agent through the CSF space access catheter and implantable flow control mechanisms (64) are provided for controlling the rate and volume of CSF drainage from the CSF space.
PCT/US2002/026435 2001-08-21 2002-08-19 Combined drug and csf removal therapies and systems WO2003015710A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002313778A AU2002313778A1 (en) 2001-08-21 2002-08-19 Combined drug and csf removal therapies and systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31393801P 2001-08-21 2001-08-21
US60/313,938 2001-08-21

Publications (2)

Publication Number Publication Date
WO2003015710A2 WO2003015710A2 (en) 2003-02-27
WO2003015710A3 true WO2003015710A3 (en) 2004-02-12

Family

ID=23217836

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/026435 WO2003015710A2 (en) 2001-08-21 2002-08-19 Combined drug and csf removal therapies and systems

Country Status (2)

Country Link
AU (1) AU2002313778A1 (en)
WO (1) WO2003015710A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60134654D1 (en) 2000-09-11 2008-08-14 Csf Dynamics As LIQUID LIQUID DEVICE FOR TREATING THE HYDROCEPHALUS
ES2307396B1 (en) * 2006-09-14 2009-09-30 Fundacion Para Investigaciones Neurologicas (Fin) SYSTEMS FOR THE ELIMINATION OF NEUROTOXIC SUBSTANCES CAUSING NEURODEGENERATIVE DISEASES THROUGH THEIR SELECTIVE ATTACKING BY IMMUNOFINITY IN THE CIRCULATING CEPHALO-RAQUIDEO LIQUID.
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
JP2010505556A (en) 2006-10-09 2010-02-25 ニューロフルーディクス， インコーポレイテッド Cerebrospinal fluid purification system
WO2011114260A1 (en) 2010-03-19 2011-09-22 Pfizer Inc. Cerebrospinal fluid purification system
US20150038948A1 (en) * 2013-07-31 2015-02-05 G-Tech Electronic Research & Development, LLC Apparatus and use of a neurochemisrty regulator device insertable in the cranium for the treatment of cerebral cortical disorders
US9421348B2 (en) 2013-10-01 2016-08-23 Ecole Polytechnique Federale De Lausanne (Epfl) Systems and methods for moving and circulating fluid to treat alzheimer's disease
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
EP3714915B1 (en) 2015-08-05 2021-11-03 Minnetronix Inc. Tangential flow filter system for the filtration of materials from biologic fluids
ES2856599T3 (en) 2015-12-04 2021-09-27 Minnetronix Inc Cerebrospinal fluid conditioning systems
CN107088257B (en) * 2017-04-27 2023-06-09 哈尔滨医科大学 A Y-type dual-purpose double-cavity and two-bag drainage device
AU2019310040A1 (en) 2018-07-23 2021-02-11 Enclear Therapies, Inc. Methods of treating neurological disorders
CN113164563A (en) 2018-07-23 2021-07-23 因柯利尔疗法公司 Method of treatment of neurological disorders
AU2020271894A1 (en) * 2019-04-11 2021-12-02 Enclear Therapies, Inc. Methods of amelioration of cerebrospinal fluid and devices and systems therefor
US11559626B2 (en) 2020-04-08 2023-01-24 Medtronic, Inc. Means to treat Alzheimer's disease via flushing of brain parenchyma
JP2023543868A (en) * 2020-09-29 2023-10-18 エンクリアー セラピーズ， インク． Subarachnoid fluid management methods and systems

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5957912A (en) * 1998-04-16 1999-09-28 Camino Neurocare, Inc. Catheter having distal stylet opening and connector
US6193691B1 (en) * 1999-03-30 2001-02-27 Depuy Orthopaedics, Inc. Catheter system
US6210346B1 (en) * 1989-10-11 2001-04-03 Edwards Lifesciences Corp. Method for inserting an intracranial catheter and for monitoring intracranial pressure in a mammal
US20030135148A1 (en) * 2002-01-14 2003-07-17 Dextradeur Alan J. Multi-catheter insertion device and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210346B1 (en) * 1989-10-11 2001-04-03 Edwards Lifesciences Corp. Method for inserting an intracranial catheter and for monitoring intracranial pressure in a mammal
US5957912A (en) * 1998-04-16 1999-09-28 Camino Neurocare, Inc. Catheter having distal stylet opening and connector
US6193691B1 (en) * 1999-03-30 2001-02-27 Depuy Orthopaedics, Inc. Catheter system
US20030135148A1 (en) * 2002-01-14 2003-07-17 Dextradeur Alan J. Multi-catheter insertion device and method

Also Published As

Publication number Publication date
WO2003015710A2 (en) 2003-02-27
AU2002313778A1 (en) 2003-03-03

Similar Documents

Publication Publication Date Title
WO2003015710A3 (en) Combined drug and csf removal therapies and systems
US7887503B2 (en) Method and apparatus for removing harmful proteins from a mammalian's ventricular cerebrospinal fluid
US20230058368A1 (en) Therapeutic applications of artificial cerebrospinal fluid and tools provided therefor
AU2003200925B2 (en) Convection-enhanced drug delivery device and method of use
EP3052179B1 (en) Systems for moving and circulating fluid to treat alzheimer's disease
US11541175B2 (en) Therapeutic applications of artificial cerebrospinal fluid and tools provided therefor
WO2006044115A3 (en) Method of treating parkinson's disease by convection-enhanced infusion of glial cell-line derived neurotrophic factor (gdnf) to the putamen
WO2006014764A3 (en) Implantable cerebral spinal fluid drainage device and method of draining cerebral spinal fluid
WO2004008826A3 (en) Systems and methods for performing peritoneal dialysis
WO2005061026A3 (en) Medical fluid therapy flow control systems and methods
CA2421727A1 (en) A fluid shunt system and a method for the treatment of hydrocephalus
WO2003066123A3 (en) Microinfusion device
WO2006135766A3 (en) Regional therapies for treatment of pain
DE60023668D1 (en) FOR THE CENTRAL NERVOUS SYSTEM DETERMINED CATHETER WITH TEMPERATURE CONTROL SYSTEM
WO2005028015A3 (en) Methods and apparatus for localized and semi-localized drug delivery
WO2003068049A3 (en) Controlled cerebrospinal infusion and shunt system
WO2007130718A3 (en) Implantable micro-system for treatment of hydrocephalus
WO2007119178A3 (en) Infusion pump
MXPA04006534A (en) Infusion system.
US20090131857A1 (en) Method and apparatus for introducing a medicinal dose directly into a mammalian patient's cerebrospinal fluid
WO2002085431A2 (en) Method of delivering liquid through cerebral spinal pathway
WO2001054766A1 (en) Systems and methods for exchanging cerebrospinal fluid
CA2486934C (en) Systems for csf drainage
Turner The treatment of hydrocephalus: A brief guide to shunt selection
US20070055196A1 (en) Implantable shunt system and method

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载