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WO2003012395A3 - Detection precoce de maladies mycobacteriennes au moyen de peptides - Google Patents

Detection precoce de maladies mycobacteriennes au moyen de peptides Download PDF

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Publication number
WO2003012395A3
WO2003012395A3 PCT/US2002/024297 US0224297W WO03012395A3 WO 2003012395 A3 WO2003012395 A3 WO 2003012395A3 US 0224297 W US0224297 W US 0224297W WO 03012395 A3 WO03012395 A3 WO 03012395A3
Authority
WO
WIPO (PCT)
Prior art keywords
mtb
early
peptides
antibodies
antigens
Prior art date
Application number
PCT/US2002/024297
Other languages
English (en)
Other versions
WO2003012395A2 (fr
Inventor
Suman Laal
Susan Zolla-Pazner
John T Belisle
Original Assignee
Univ New York
Univ Colorado State
Suman Laal
Susan Zolla-Pazner
John T Belisle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York, Univ Colorado State, Suman Laal, Susan Zolla-Pazner, John T Belisle filed Critical Univ New York
Priority to AU2002324578A priority Critical patent/AU2002324578B2/en
Priority to EP02759228A priority patent/EP1463526A4/fr
Publication of WO2003012395A2 publication Critical patent/WO2003012395A2/fr
Publication of WO2003012395A3 publication Critical patent/WO2003012395A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

De nombreux antigènes de protéines et de glycoprotéines sécrétés par Mycobacterium tuberculosis (Mtb) ont été identifiés comme antigènes « précoces » de Mtb sur la base d'anticorps précoces présents chez les sujets infectés par la Mtb avant le développement d'une maladie clinique décelable. Des fragments de peptides porteurs d'épitopes desdits antigènes précoces de Mtb, en particulier d'une protéine secrétée de 88kDa, la GlcB (SEQ ID NO : 106) et d'un antigène de Mtb MPT51 (SEQ ID NO : 107) ont été identifiés. Lesdits peptides, des variants de ces derniers, des peptides multimères de ces derniers qui comprennent deux ou plusieurs répétitions d'un ou plusieurs peptides, et des peptides de fusion comprenant des protéines de Mtb antigéniques précoces, des peptides, ou les deux, sont utiles dans des méthodes d'immunoessais pour une détection précoce, rapide de la tuberculose (TB) chez un sujet. Des immunoessais préférés permettent de détecter les anticorps dans les urines d'un sujet. L'invention concerne en outre des compositions d'antigènes, des kits et des méthodes utiles dans la détection d'anticorps de Mtb précoces. Lesdites protéines et lesdits peptides antigéniques sont en outre utilisés dans des compositions de vaccins.
PCT/US2002/024297 2001-08-02 2002-08-02 Detection precoce de maladies mycobacteriennes au moyen de peptides WO2003012395A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002324578A AU2002324578B2 (en) 2001-08-02 2002-08-02 Early detection of mycobacterial disease using peptides
EP02759228A EP1463526A4 (fr) 2001-08-02 2002-08-02 Detection precoce de maladies mycobacteriennes au moyen de peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30918501P 2001-08-02 2001-08-02
US60/309,185 2001-08-02

Publications (2)

Publication Number Publication Date
WO2003012395A2 WO2003012395A2 (fr) 2003-02-13
WO2003012395A3 true WO2003012395A3 (fr) 2004-07-22

Family

ID=23197061

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024297 WO2003012395A2 (fr) 2001-08-02 2002-08-02 Detection precoce de maladies mycobacteriennes au moyen de peptides

Country Status (5)

Country Link
EP (1) EP1463526A4 (fr)
CN (1) CN1694725A (fr)
AU (1) AU2002324578B2 (fr)
WO (1) WO2003012395A2 (fr)
ZA (1) ZA200400843B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101311189B (zh) * 2006-06-06 2010-09-08 中国人民解放军第二军医大学 激发人体抗结核杆菌的保护性免疫反应的抗原表位及其用途
CN100415771C (zh) * 2006-06-06 2008-09-03 中国人民解放军第二军医大学 激发人体抗结核杆菌的保护性免疫反应的抗原表位及其用途
CN101298471B (zh) * 2006-06-06 2011-01-19 中国人民解放军第二军医大学 激发人体抗结核杆菌的保护性免疫反应的抗原表位及其用途
ES2307402B1 (es) * 2006-10-30 2009-09-30 Archivel Farma, S.L. Vacuna profilactica contra la tuberculosis.
BRPI0905725B8 (pt) * 2008-01-11 2021-05-25 Univ Emory vacina e embalagem farmacêutica
CN101235090B (zh) * 2008-01-31 2012-02-22 复旦大学 一种应用于结核病快速诊断的特异性融合蛋白及其构建方法
CA2758124A1 (fr) * 2008-04-19 2009-10-22 New York University Peptide de mycobacterium tuberculosis immunodominants provenant de proteines de paroi cellulaire pour un diagnostic precoce et une immunisation
CN102675425B (zh) * 2011-04-22 2013-12-04 中国医学科学院病原生物学研究所 一种功能性结核分枝杆菌抗原多肽及其应用
WO2012177520A2 (fr) * 2011-06-20 2012-12-27 Matthias Rath Oligopeptides et leur utilisation pour le traitement de maladies infectieuses
CA2941236A1 (fr) * 2014-03-07 2015-09-11 Institute For Systems Biology Dosages au point d'intervention pour detecter le statut d'une infection tuberculeuse
CN110045112B (zh) * 2015-03-31 2022-08-05 希森美康株式会社 免疫测定装置
US20210072235A1 (en) * 2017-12-22 2021-03-11 Sugentech, Inc. Method for diagnosing tuberculosis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5330754A (en) * 1992-06-29 1994-07-19 Archana Kapoor Membrane-associated immunogens of mycobacteria

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD295869A5 (de) * 1989-09-19 1991-11-14 �K�K@������������@�K�Kk�� Rekombinante polypeptide und peptide, diese codierende nucleinsaeuren und verwendung dieser polypeptide und peptide in der diagnose von tuberkulose
DE4440118C1 (de) * 1994-11-11 1995-11-09 Forschungszentrum Juelich Gmbh Die Genexpression in coryneformen Bakterien regulierende DNA
US6290969B1 (en) * 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
CA2276491C (fr) * 1996-12-31 2008-01-22 New York University Depistage precoce des maladies mycobacteriennes
US6245331B1 (en) * 1997-01-02 2001-06-12 New York Univ. Medical Center Early detection of mycobacterial disease
AU6029898A (en) * 1997-01-21 1998-08-07 Regents Of The University Of California, The Abundant extracellular products and methods for their production and use
US20030027774A1 (en) * 1999-03-18 2003-02-06 Ronald C. Hendrickson Tuberculosis antigens and methods of use therefor
EP1263963A2 (fr) * 1999-06-25 2002-12-11 Basf Aktiengesellschaft Proteines codant pour les genes corynebacterium glutamicum, intervenant dans le metabolisme du carbone et dans la production d'energie
JP2003510370A (ja) * 1999-10-07 2003-03-18 コリクサ コーポレイション Ｍｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓの融合タンパク質

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5330754A (en) * 1992-06-29 1994-07-19 Archana Kapoor Membrane-associated immunogens of mycobacteria

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BASSEY E.O.E. ET AL.: "Candidate antigens for improved serodiagnosis of tuberculosis", TUBERCLE AND LUNG DISEASE, vol. 77, no. 2, April 1996 (1996-04-01), pages 136 - 145, XP004540072 *

Also Published As

Publication number Publication date
ZA200400843B (en) 2007-11-28
WO2003012395A2 (fr) 2003-02-13
AU2002324578B2 (en) 2009-02-05
EP1463526A2 (fr) 2004-10-06
CN1694725A (zh) 2005-11-09
EP1463526A4 (fr) 2006-08-30

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