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WO2003012395A3 - Early detection of mycobacterial disease using peptides - Google Patents

Early detection of mycobacterial disease using peptides Download PDF

Info

Publication number
WO2003012395A3
WO2003012395A3 PCT/US2002/024297 US0224297W WO03012395A3 WO 2003012395 A3 WO2003012395 A3 WO 2003012395A3 US 0224297 W US0224297 W US 0224297W WO 03012395 A3 WO03012395 A3 WO 03012395A3
Authority
WO
WIPO (PCT)
Prior art keywords
mtb
early
peptides
antibodies
antigens
Prior art date
Application number
PCT/US2002/024297
Other languages
French (fr)
Other versions
WO2003012395A2 (en
Inventor
Suman Laal
Susan Zolla-Pazner
John T Belisle
Original Assignee
Univ New York
Univ Colorado State
Suman Laal
Susan Zolla-Pazner
John T Belisle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York, Univ Colorado State, Suman Laal, Susan Zolla-Pazner, John T Belisle filed Critical Univ New York
Priority to AU2002324578A priority Critical patent/AU2002324578B2/en
Priority to EP02759228A priority patent/EP1463526A4/en
Publication of WO2003012395A2 publication Critical patent/WO2003012395A2/en
Publication of WO2003012395A3 publication Critical patent/WO2003012395A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A number of protein and glycoprotein antigens secreted by Mycobacterium tuberculosis (Mtb) have been identified as 'early' Mtb antigens on the basis early antibodies present in subjects infected with Mtb prior to the development of detectable clinical disease. Epitope-bearing peptide fragments of these early Mtb antigens, in particular of an 88 kDa secreted protein, GlcB (SEQ ID NO:106) and of Mtb antigen MPT51 (SEQ ID NO:107) have been identified. These peptides, variants thereof, peptide multimers thereof that include two or more repeats of one or more of the peptides, and fusion polypeptides that include early Mtb antigenic proteins, peptides or both, are useful in immunoassay methods for early, rapid detection of TB in a subject. Preferred immunoassays detect the antibodies in the subject's urine. Also provided are antigenic compositions, kits and methods to useful for detecting an early Mtb antibodies. The antigenic proteins and peptides are also used in vaccine compositions.
PCT/US2002/024297 2001-08-02 2002-08-02 Early detection of mycobacterial disease using peptides WO2003012395A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002324578A AU2002324578B2 (en) 2001-08-02 2002-08-02 Early detection of mycobacterial disease using peptides
EP02759228A EP1463526A4 (en) 2001-08-02 2002-08-02 EARLY IDENTIFICATION OF MYCOBACTERIAL DISEASE USING PEPTIDES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30918501P 2001-08-02 2001-08-02
US60/309,185 2001-08-02

Publications (2)

Publication Number Publication Date
WO2003012395A2 WO2003012395A2 (en) 2003-02-13
WO2003012395A3 true WO2003012395A3 (en) 2004-07-22

Family

ID=23197061

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024297 WO2003012395A2 (en) 2001-08-02 2002-08-02 Early detection of mycobacterial disease using peptides

Country Status (5)

Country Link
EP (1) EP1463526A4 (en)
CN (1) CN1694725A (en)
AU (1) AU2002324578B2 (en)
WO (1) WO2003012395A2 (en)
ZA (1) ZA200400843B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101311189B (en) * 2006-06-06 2010-09-08 中国人民解放军第二军医大学 Antigen epitope for stimulating human body's protective immune response against Mycobacterium tuberculosis and use thereof
CN100415771C (en) * 2006-06-06 2008-09-03 中国人民解放军第二军医大学 Antigen epitope for stimulating human body's protective immune response against Mycobacterium tuberculosis and use thereof
CN101298471B (en) * 2006-06-06 2011-01-19 中国人民解放军第二军医大学 Antigen epitope for stimulating human body's protective immune response against Mycobacterium tuberculosis and use thereof
ES2307402B1 (en) * 2006-10-30 2009-09-30 Archivel Farma, S.L. PROFILACTIC VACCINE AGAINST TUBERCULOSIS.
BRPI0905725B8 (en) * 2008-01-11 2021-05-25 Univ Emory vaccine and pharmaceutical packaging
CN101235090B (en) * 2008-01-31 2012-02-22 复旦大学 A specific fusion protein for rapid diagnosis of tuberculosis and its construction method
CA2758124A1 (en) * 2008-04-19 2009-10-22 New York University Immunodominant mycobacterium tuberculosis peptides from cell wall proteins for early diagnosis and immunization
CN102675425B (en) * 2011-04-22 2013-12-04 中国医学科学院病原生物学研究所 Functional mycobacterium tuberculosis antigen polypeptide and application thereof
WO2012177520A2 (en) * 2011-06-20 2012-12-27 Matthias Rath Oligopeptides and their use for treating infectious diseases
CA2941236A1 (en) * 2014-03-07 2015-09-11 Institute For Systems Biology Point of care assays to detect the status of tuberculosis infection
CN110045112B (en) * 2015-03-31 2022-08-05 希森美康株式会社 Immunoassay device
US20210072235A1 (en) * 2017-12-22 2021-03-11 Sugentech, Inc. Method for diagnosing tuberculosis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5330754A (en) * 1992-06-29 1994-07-19 Archana Kapoor Membrane-associated immunogens of mycobacteria

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD295869A5 (en) * 1989-09-19 1991-11-14 �K�K@������������@�K�Kk�� RECOMBINANT POLYPEPTIDES AND PEPTIDES, THESE CODING NUCLEINE ACIDS, AND THE USE OF THESE POLYPEPTIDES AND PEPTIDES IN THE DIAGNOSIS OF TUBERCULOSIS
DE4440118C1 (en) * 1994-11-11 1995-11-09 Forschungszentrum Juelich Gmbh Gene expression in coryneform bacteria regulating DNA
US6290969B1 (en) * 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
CA2276491C (en) * 1996-12-31 2008-01-22 New York University Early detection of mycobacterial disease
US6245331B1 (en) * 1997-01-02 2001-06-12 New York Univ. Medical Center Early detection of mycobacterial disease
AU6029898A (en) * 1997-01-21 1998-08-07 Regents Of The University Of California, The Abundant extracellular products and methods for their production and use
US20030027774A1 (en) * 1999-03-18 2003-02-06 Ronald C. Hendrickson Tuberculosis antigens and methods of use therefor
EP1263963A2 (en) * 1999-06-25 2002-12-11 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production
JP2003510370A (en) * 1999-10-07 2003-03-18 コリクサ コーポレイション Fusion protein of Mycobacterium tuberculosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5330754A (en) * 1992-06-29 1994-07-19 Archana Kapoor Membrane-associated immunogens of mycobacteria

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BASSEY E.O.E. ET AL.: "Candidate antigens for improved serodiagnosis of tuberculosis", TUBERCLE AND LUNG DISEASE, vol. 77, no. 2, April 1996 (1996-04-01), pages 136 - 145, XP004540072 *

Also Published As

Publication number Publication date
ZA200400843B (en) 2007-11-28
WO2003012395A2 (en) 2003-02-13
AU2002324578B2 (en) 2009-02-05
EP1463526A2 (en) 2004-10-06
CN1694725A (en) 2005-11-09
EP1463526A4 (en) 2006-08-30

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