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WO2003001178A2 - Jeu ordonne tridimensionnel dynamique de sondes - Google Patents

Jeu ordonne tridimensionnel dynamique de sondes Download PDF

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Publication number
WO2003001178A2
WO2003001178A2 PCT/US2002/011586 US0211586W WO03001178A2 WO 2003001178 A2 WO2003001178 A2 WO 2003001178A2 US 0211586 W US0211586 W US 0211586W WO 03001178 A2 WO03001178 A2 WO 03001178A2
Authority
WO
WIPO (PCT)
Prior art keywords
optical
probes
probe
light
traps
Prior art date
Application number
PCT/US2002/011586
Other languages
English (en)
Other versions
WO2003001178A3 (fr
Inventor
Lewis Gruber
David Grier
Ward Lopes
Original Assignee
Arryx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arryx, Inc. filed Critical Arryx, Inc.
Priority to NZ530239A priority Critical patent/NZ530239A/en
Priority to JP2003507524A priority patent/JP4199107B2/ja
Priority to CA002451222A priority patent/CA2451222A1/fr
Priority to EP02731351A priority patent/EP1412519A4/fr
Publication of WO2003001178A2 publication Critical patent/WO2003001178A2/fr
Publication of WO2003001178A3 publication Critical patent/WO2003001178A3/fr
Priority to US10/735,395 priority patent/US20040180363A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00441—Maskless processes using lasers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00664—Three-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Definitions

  • the optical bottle differs from an optical vortex in that it has a zero electric field only at the focus and a non-zero electric field in all other directions surrounding the focus, at an end of the vortex.
  • An optical bottle may be useful in trapping atoms and nanoclusters which may be too small or too absorptive to trap with an optical vortex or optical tweezers.
  • the optical rotator is a recently described optical tool which provides a pattern of spiral arms which trap objects. Changing the pattern causes the trapped objects to rotate.
  • FIG. 5 A illustrates a first operative movement of probes.
  • FIG. 6B illustrates an inverted microscope to which the compact system of Fig. 6A attaches.
  • Preferred dynamic optical elements include phase-only spatial light modulators such as the "PAL-SLM series X7665", manufactured by Hamamatsu, of Japan or the "SLM 512N15' and SLM 512SA7,” both manufactured by Boulder Nonlinear Systems of Layafette Colorado. These phase patterning optical elements are computer controlled to generate the beamlets 2000-2004 (FIG. 1) by a hologram encoded in the medium which can be varied to generate the beamlets and select the form of the beamlets.
  • phase-only spatial light modulators such as the "PAL-SLM series X7665", manufactured by Hamamatsu, of Japan or the "SLM 512N15' and SLM 512SA7,” both manufactured by Boulder Nonlinear Systems of Layafette Colorado.
  • These phase patterning optical elements are computer controlled to generate the beamlets 2000-2004 (FIG. 1) by a hologram encoded in the medium which can be varied to generate the beamlets and select the form of the beamlets.
  • the probes can be added to the vessel 10 in a sequential order.
  • identity of a probe is known by its load order or a probe's identify can be known on the basis of the time that the probe is added.
  • the probes having binding or reactivity characteristics that differ from one another can be segregated to different predetermined locations, based on the difference in properties. The probes are then selected on the basis of their location within the vessel. As seen in FIG.
  • the sequence may continue passing the probes from the second set of predetermined positions P2 to a third set of predetermined positions P3, from the third set of positions P3 to a fourth set of predetermined positions P4, and from the fourth set of predetermined positions P4 to a fifth set of predetermined positions P5 by the rotation of the phase patterning optical element to align the appropriate region 42-46 corresponding to the desired position P1-P5.
  • the time interval between the termination of one set of optical traps and the generation of the next should be of a duration to ensure that the probes are transferred to the next set of optical traps before they drift away.
  • a dichroic mirror beam splitter 58 Interposed in the third light channel between the second light channel and the back aperture 57 of the focusing lens is a dichroic mirror beam splitter 58.
  • Other components within the compact system for forming the optical traps 50 include a first mirror Ml, which reflects the beamlets emanating from the phase patterning optical element through the first light channel, a first set of transfer optics TOl disposed within the first light channel, aligned to receive the beamlets reflected by the first mirror Ml, a second set of transfer optics TO2 disposed within the first light channel, aligned to receive the beamlets passing through the first set of transfer lenses TOl, and a second mirror M2, positioned at the intersection of the first light channel and the second light channel, aligned to reflect beamlets passing through the second set of transfer optics TO2 and through the third light channel 55 a.
  • FIG. 6B Shown in FIG. 6B is an elevational view of a Nixon TE 200 series microscope into which the compact system for forming the optical traps 50 has been mounted, generally designated 60.
  • the nosepiece 54 with the attached a housing 52 fits directly into the microscope via the mount (not shown) for the nosepiece 54a and 54b.
  • the housing and its contents and attached optical element 51 are secured to the nosepiece 54a and 54b require few or no alterations or modifications to the remainder of the microscope.
  • an illumination source 61 may be provided above the objective lens 56.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Composite Materials (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

De façon générale, la présente invention concerne un jeu ordonné de sondes pour l'analyse de cibles à l'intérieur d'un fluide. Les sondes sont logées dans des pièges optiques qui permettent de modifier la sélection ainsi que la quantité ou la qualité desdites sondes. Par ailleurs, ce jeu ordonné est dynamique dans la mesure où il est possible de repositionner un piège optique donné et la sonde qu'il contient un fois les pièges optiques configurés.
PCT/US2002/011586 2001-06-20 2002-04-12 Jeu ordonne tridimensionnel dynamique de sondes WO2003001178A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
NZ530239A NZ530239A (en) 2001-06-20 2002-04-12 Configurable dynamic three dimensional array
JP2003507524A JP4199107B2 (ja) 2001-06-20 2002-04-12 配列可能な動的３次元アレイ
CA002451222A CA2451222A1 (fr) 2001-06-20 2002-04-12 Jeu ordonne tridimensionnel dynamique de sondes
EP02731351A EP1412519A4 (fr) 2001-06-20 2002-04-12 Jeu ordonne tridimensionnel dynamique de sondes
US10/735,395 US20040180363A1 (en) 2002-04-12 2003-12-12 Configurable dynamic three dimensional array

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88680201A 2001-06-20 2001-06-20
US09/886,802 2001-06-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/735,395 Continuation-In-Part US20040180363A1 (en) 2002-04-12 2003-12-12 Configurable dynamic three dimensional array

Publications (2)

Publication Number Publication Date
WO2003001178A2 true WO2003001178A2 (fr) 2003-01-03
WO2003001178A3 WO2003001178A3 (fr) 2003-02-27

Family

ID=25389806

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/011586 WO2003001178A2 (fr) 2001-06-20 2002-04-12 Jeu ordonne tridimensionnel dynamique de sondes

Country Status (7)

Country Link
EP (1) EP1412519A4 (fr)
JP (1) JP4199107B2 (fr)
CN (2) CN1715918B (fr)
CA (1) CA2451222A1 (fr)
HK (1) HK1078933A1 (fr)
NZ (1) NZ530239A (fr)
WO (1) WO2003001178A2 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1469483A2 (fr) 2003-04-16 2004-10-20 Shamci Dr. Monajemsbashi Echantillon pour manipulation par pinces optiques, et procédé et dispositif pour engendrer des forces induites optiquement
JP2007510160A (ja) * 2003-10-28 2007-04-19 アリックス インコーポレイテッド ホログラフィック光トラッピングを用いて物質を操作し、処理するためのシステム及び方法
JP2007537885A (ja) * 2004-03-17 2007-12-27 アリックス インコーポレイテッド ホログラフィック光トラッピングを用いて物質を操作し、処理するためのシステム及び方法
US7525088B2 (en) 2004-07-23 2009-04-28 The Science And Technology Facilities Council Optically controllable device
US8169600B2 (en) 2006-09-15 2012-05-01 Arryx, Inc. Surface mapping by optical manipulation of particles in relation to a functionalized surface
EP2150806A4 (fr) * 2007-05-10 2013-01-02 Pacific Biosciences California Procédés et systèmes d'analyse de matière fluorescente à autofluorescence limitée
KR20150023810A (ko) * 2012-06-18 2015-03-05 존 마일즈 브루배춰 미생물 평가 시스템

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010538645A (ja) * 2007-09-11 2010-12-16 アリックス インク 対象物を選別するための結合方法および装置
WO2009035621A1 (fr) * 2007-09-13 2009-03-19 Arryx, Inc. Procédés et appareils pour trier des objets dans une analyse médico-légale d'arn et dans des diagnostics médicaux
PL2280875T3 (pl) * 2008-04-23 2012-10-31 Signode Int Ip Holdings Llc Urządzenie do opasywania taśmą ściągającą z układem przekładni
CN109239937A (zh) * 2018-09-15 2019-01-18 天津大学 一种光镊自动化操控装置
CN113053556A (zh) * 2021-03-10 2021-06-29 暨南大学 具有可重构性的生物微马达阵列及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3102523B2 (ja) * 1992-10-12 2000-10-23 日本電信電話株式会社 微粒子の配列制御方法
US5776674A (en) * 1995-06-05 1998-07-07 Seq, Ltd Chemical biochemical and biological processing in thin films
CN1079158C (zh) * 1996-11-26 2002-02-13 中国科学院上海光学精密机械研究所 光悬浮测量系统
US6055106A (en) * 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1469483A2 (fr) 2003-04-16 2004-10-20 Shamci Dr. Monajemsbashi Echantillon pour manipulation par pinces optiques, et procédé et dispositif pour engendrer des forces induites optiquement
EP1469483A3 (fr) * 2003-04-16 2009-06-03 Monajemsbashi, Shamci, Dr. Echantillon pour manipulation par pinces optiques, et procédé et dispositif pour engendrer des forces induites optiquement
JP2007510160A (ja) * 2003-10-28 2007-04-19 アリックス インコーポレイテッド ホログラフィック光トラッピングを用いて物質を操作し、処理するためのシステム及び方法
EP1687663A4 (fr) * 2003-10-28 2010-03-31 Arryx Inc Systeme et procede de manipulation et de traitement de nano-materiaux faisant appel au piegeage optique holographique
JP2007537885A (ja) * 2004-03-17 2007-12-27 アリックス インコーポレイテッド ホログラフィック光トラッピングを用いて物質を操作し、処理するためのシステム及び方法
EP1745530A4 (fr) * 2004-03-17 2009-08-05 Arryx Inc Systeme et procede pour manipuler et traiter des materiaux par piegeage optique holographique
US7525088B2 (en) 2004-07-23 2009-04-28 The Science And Technology Facilities Council Optically controllable device
US8169600B2 (en) 2006-09-15 2012-05-01 Arryx, Inc. Surface mapping by optical manipulation of particles in relation to a functionalized surface
EP2150806A4 (fr) * 2007-05-10 2013-01-02 Pacific Biosciences California Procédés et systèmes d'analyse de matière fluorescente à autofluorescence limitée
KR20150023810A (ko) * 2012-06-18 2015-03-05 존 마일즈 브루배춰 미생물 평가 시스템
KR102102285B1 (ko) 2012-06-18 2020-04-20 존 마일즈 브루배춰 미생물 평가 시스템

Also Published As

Publication number Publication date
HK1078933A1 (en) 2006-03-24
JP2004532991A (ja) 2004-10-28
EP1412519A4 (fr) 2007-07-04
JP4199107B2 (ja) 2008-12-17
CN1715918A (zh) 2006-01-04
CN1715918B (zh) 2010-05-12
CA2451222A1 (fr) 2003-01-03
NZ530239A (en) 2006-08-31
WO2003001178A3 (fr) 2003-02-27
EP1412519A2 (fr) 2004-04-28
CN1545561A (zh) 2004-11-10

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