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WO2003000873A3 - Régulation de la sérine/thréonine protéine kinase humaine nek1 - Google Patents

Régulation de la sérine/thréonine protéine kinase humaine nek1 Download PDF

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Publication number
WO2003000873A3
WO2003000873A3 PCT/EP2002/006879 EP0206879W WO03000873A3 WO 2003000873 A3 WO2003000873 A3 WO 2003000873A3 EP 0206879 W EP0206879 W EP 0206879W WO 03000873 A3 WO03000873 A3 WO 03000873A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
threonine protein
human serine
regulation
nek1
Prior art date
Application number
PCT/EP2002/006879
Other languages
English (en)
Other versions
WO2003000873A2 (fr
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to AU2002312997A priority Critical patent/AU2002312997A1/en
Publication of WO2003000873A2 publication Critical patent/WO2003000873A2/fr
Publication of WO2003000873A3 publication Critical patent/WO2003000873A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des réactifs régulant la sérine/thréonine protéine kinase NEK1 et des réactifs se liant à des produits génétiques de la sérine/thréonine protéine kinase humaine NEK1. Les réactifs selon l'invention peuvent jouer un rôle dans la prévention, l'amélioration ou la correction de dysfonctionnements ou de maladies tels que par exemple, le cancer, notamment le cancer du côlon, les troubles cardio-vasculaires, les troubles du système nerveux central, le diabète ou la bronchopneumopathie chronique obstructive.
PCT/EP2002/006879 2001-06-25 2002-06-21 Régulation de la sérine/thréonine protéine kinase humaine nek1 WO2003000873A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002312997A AU2002312997A1 (en) 2001-06-25 2002-06-21 Regulation of human serine/threonine protein kinase nek1

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US30007101P 2001-06-25 2001-06-25
US60/300,071 2001-06-25
US33144701P 2001-11-16 2001-11-16
US60/331,447 2001-11-16
US33669301P 2001-12-07 2001-12-07
US60/336,693 2001-12-07

Publications (2)

Publication Number Publication Date
WO2003000873A2 WO2003000873A2 (fr) 2003-01-03
WO2003000873A3 true WO2003000873A3 (fr) 2003-03-20

Family

ID=27404691

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/006879 WO2003000873A2 (fr) 2001-06-25 2002-06-21 Régulation de la sérine/thréonine protéine kinase humaine nek1

Country Status (2)

Country Link
AU (1) AU2002312997A1 (fr)
WO (1) WO2003000873A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2377885T3 (es) * 2005-12-27 2012-04-02 Genentech, Inc. Uso de antagonistas de hedgehog cinasa para inhibir la señalización de hedgehog y para tratar cáncer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHO-CHUNG YOON S: "Antisense oligonucleotide inhibition of serine/threonine kinases: An innovative approach to cancer treatment.", PHARMACOLOGY & THERAPEUTICS, vol. 82, no. 2-3, May 1999 (1999-05-01), pages 437 - 449, XP002224531, ISSN: 0163-7258 *
DATABASE EMBL [online] 1 October 1996 (1996-10-01), LETWIN ET AL.: "Serine/threonine-protein kinase NEK1 (EC 2.7.1.37)", XP002224533, retrieved from EBI Database accession no. P51954 *
DATABASE EMBL [online] 27 May 1999 (1999-05-27), KOEHRER ET AL.: "Homo sapiens mRNA; DKFZp564L2416", XP002224532, retrieved from EBI Database accession no. AL050385 *
LEE J C ET AL: "INHIBITORS OF SERINE/THEONINE KENASES", CURRENT OPINION IN BIOTECHNOLOGY, LONDON, GB, vol. 6, no. 6, 1995, pages 657 - 661, XP000567263, ISSN: 0958-1669 *
LETWIN K ET AL: "A MAMMALIAN DUAL SPECIFICITY PROTEIN KINASE NEK1 IS RELATED TO THE NIMA CELL CYCLE REGULATOR AND HIGHLY EXPRESSED IN MEIOTIC GERM CELLS", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 11, no. 10, 1992, pages 3521 - 3531, XP002160269, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
AU2002312997A1 (en) 2003-01-08
WO2003000873A2 (fr) 2003-01-03

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