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WO2003068790A3 - Macrolide antibacterial compounds - Google Patents

Macrolide antibacterial compounds Download PDF

Info

Publication number
WO2003068790A3
WO2003068790A3 PCT/US2003/004117 US0304117W WO03068790A3 WO 2003068790 A3 WO2003068790 A3 WO 2003068790A3 US 0304117 W US0304117 W US 0304117W WO 03068790 A3 WO03068790 A3 WO 03068790A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
antibacterial compounds
macrolide antibacterial
prodrugs
salts
Prior art date
Application number
PCT/US2003/004117
Other languages
French (fr)
Other versions
WO2003068790A2 (en
Inventor
Zhenkun Ma
Richard Clark
Stevan Djuric
Sanyi Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/075,011 external-priority patent/US20030171308A1/en
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to CA002476223A priority Critical patent/CA2476223A1/en
Priority to MXPA04007883A priority patent/MXPA04007883A/en
Priority to JP2003567916A priority patent/JP2005522453A/en
Priority to EP03707854A priority patent/EP1474431A2/en
Publication of WO2003068790A2 publication Critical patent/WO2003068790A2/en
Publication of WO2003068790A3 publication Critical patent/WO2003068790A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Antibacterial compounds having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.
PCT/US2003/004117 2002-02-13 2003-02-11 Macrolide antibacterial compounds WO2003068790A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002476223A CA2476223A1 (en) 2002-02-13 2003-02-11 Macrolide antibacterial compounds
MXPA04007883A MXPA04007883A (en) 2002-02-13 2003-02-11 Macrolide antibacterial compounds.
JP2003567916A JP2005522453A (en) 2002-02-13 2003-02-11 Macrolide antibacterial compounds
EP03707854A EP1474431A2 (en) 2002-02-13 2003-02-11 Macrolide antibacterial compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/075,011 US20030171308A1 (en) 2002-02-13 2002-02-13 Macrolide antibacterial compounds
US10/075,011 2002-02-13
US36165103A 2003-02-10 2003-02-10
US10/361,651 2003-02-10

Publications (2)

Publication Number Publication Date
WO2003068790A2 WO2003068790A2 (en) 2003-08-21
WO2003068790A3 true WO2003068790A3 (en) 2003-12-04

Family

ID=27736825

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/004117 WO2003068790A2 (en) 2002-02-13 2003-02-11 Macrolide antibacterial compounds

Country Status (5)

Country Link
EP (1) EP1474431A2 (en)
JP (1) JP2005522453A (en)
CA (1) CA2476223A1 (en)
MX (1) MXPA04007883A (en)
WO (1) WO2003068790A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201509006D0 (en) * 2015-05-26 2015-07-08 Redx Pharma Plc Antibacterial compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69733369T2 (en) * 1996-09-04 2006-01-26 Abbott Laboratories, Abbott Park 6-o-substituted ketolides with antibacterial activity
CO4990960A1 (en) * 1997-10-29 2000-12-26 Abbott Lab 2-HALO-6-O SUBSTITUTED CETOLIDE DERIVATIVES

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity

Also Published As

Publication number Publication date
MXPA04007883A (en) 2004-11-26
WO2003068790A2 (en) 2003-08-21
EP1474431A2 (en) 2004-11-10
JP2005522453A (en) 2005-07-28
CA2476223A1 (en) 2003-08-21

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