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WO2003066869A8 - Gene suppresseur de tumeur lmt - Google Patents

Gene suppresseur de tumeur lmt

Info

Publication number
WO2003066869A8
WO2003066869A8 PCT/AU2003/000126 AU0300126W WO03066869A8 WO 2003066869 A8 WO2003066869 A8 WO 2003066869A8 AU 0300126 W AU0300126 W AU 0300126W WO 03066869 A8 WO03066869 A8 WO 03066869A8
Authority
WO
WIPO (PCT)
Prior art keywords
tumor suppressor
suppressor gene
present
gene
expression product
Prior art date
Application number
PCT/AU2003/000126
Other languages
English (en)
Other versions
WO2003066869A1 (fr
Inventor
Wendy Dianne Cook
Benjamin John Mccaw
Original Assignee
Inst Medical W & E Hall
Wendy Dianne Cook
Benjamin John Mccaw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Medical W & E Hall, Wendy Dianne Cook, Benjamin John Mccaw filed Critical Inst Medical W & E Hall
Priority to AU2003202315A priority Critical patent/AU2003202315A1/en
Priority to US10/512,477 priority patent/US20050172424A1/en
Publication of WO2003066869A1 publication Critical patent/WO2003066869A1/fr
Publication of WO2003066869A8 publication Critical patent/WO2003066869A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)

Abstract

La présente invention relève d'une manière générale du domaine du traitement du cancer et du dépistage du cancer et concerne des agents utilisés à cet effet. De manière plus spécifique, la présente invention concerne un nouveau gène suppresseur de tumeur, un produit d'expression comprenant un polypeptide ou une protéine codée par ce produit d'expression et des sondes et amorces nucléotidiques et des fragments peptidiques caractéristiques du gène suppresseur de tumeur ou de son produit d'expression ou des mutants ou dérivés de celui-ci. Cette invention concerne également des molécules générées par chimie combinatoire ou synthèse chimique rationnelle ou criblage suivant identifié de bibliothèques chimiques ou sources naturelles qui augmentent ou facilitent l'activité ou la fonction du gène supresseur de tumeur ou de son produit d'expression et en particulier dans des cellules qui portent une délétion ou autre mutation comprenant un événement de silençage génique dans un ou les deux allèles du gène suppresseur de tumeur. Cette invention concerne également des agents de diagnostic permettant de détecter la présence ou l'absence du gène suppresseur de tumeur expressible ou la présence ou l'absence d'un produit d'expression du gène suppresseur de tumeur utilisé pour déterminer la probabilité du développement d'une tumeur chez un animal vertébré et en particulier chez un être humain. Cette invention concerne également des animaux génétiquement modifiés porteurs de cellules dans lesquelles un ou les deux allèles du gène suppresseur de tumeur sont supprimés ou mutés ou pour lesquels l'expression du gène est silencée.
PCT/AU2003/000126 2002-02-07 2003-02-07 Gene suppresseur de tumeur lmt WO2003066869A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003202315A AU2003202315A1 (en) 2002-02-07 2003-02-07 Lmt tumor suppressor gene
US10/512,477 US20050172424A1 (en) 2002-02-07 2003-04-30 Lmt turmor suppressor gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPS0371 2002-02-07
AUPS0371A AUPS037102A0 (en) 2002-02-07 2002-02-07 A novel gene

Publications (2)

Publication Number Publication Date
WO2003066869A1 WO2003066869A1 (fr) 2003-08-14
WO2003066869A8 true WO2003066869A8 (fr) 2004-02-12

Family

ID=3833972

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2003/000126 WO2003066869A1 (fr) 2002-02-07 2003-02-07 Gene suppresseur de tumeur lmt

Country Status (3)

Country Link
US (1) US20050172424A1 (fr)
AU (1) AUPS037102A0 (fr)
WO (1) WO2003066869A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090031582A1 (en) * 2007-07-30 2009-02-05 Anyi Lu Shoe with sock lining and elastic collar
CN105779572B (zh) * 2014-12-22 2020-07-07 深圳华大基因研究院 肿瘤易感基因目标序列捕获芯片、方法及突变检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US757816A (en) * 1903-12-29 1904-04-19 Gustavus Krieger Ankle-supporting shoe.
US991036A (en) * 1910-12-13 1911-05-02 Wolf Spiegelman Shoe.
US1717432A (en) * 1928-07-12 1929-06-18 Michael Brite Ankle and arch support for children's shoes
US3590411A (en) * 1968-12-26 1971-07-06 Usm Corp Stiffening processes
US4706316A (en) * 1985-11-27 1987-11-17 Giancarlo Tanzi Method for producing footwear
CA1277135C (fr) * 1986-07-21 1990-12-04 Pierre Charles Lepine Semelle interieure reglable pour chaussure
US5152082A (en) * 1991-12-16 1992-10-06 Culpepper Thomas C Shoe and ankle support therefor
US5392532A (en) * 1993-10-18 1995-02-28 R. G. Barry Corporation Slipper having an insole attached to a peripheral outsole wall
US6079128A (en) * 1993-11-30 2000-06-27 Bauer Nike Hockey Inc. Skate boot construction with integral plastic insert
US6041524A (en) * 1998-10-05 2000-03-28 Jeffrey S. Brooks, Inc. Footwear having recessed heel cup
US6519877B2 (en) * 2001-01-12 2003-02-18 K-2 Corporation Snowboard boot with removable upper support

Also Published As

Publication number Publication date
AUPS037102A0 (en) 2002-02-28
WO2003066869A1 (fr) 2003-08-14
US20050172424A1 (en) 2005-08-11

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