WO2003066869A8 - Lmt tumor suppressor gene - Google Patents
Lmt tumor suppressor geneInfo
- Publication number
- WO2003066869A8 WO2003066869A8 PCT/AU2003/000126 AU0300126W WO03066869A8 WO 2003066869 A8 WO2003066869 A8 WO 2003066869A8 AU 0300126 W AU0300126 W AU 0300126W WO 03066869 A8 WO03066869 A8 WO 03066869A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tumor suppressor
- suppressor gene
- present
- gene
- expression product
- Prior art date
Links
- 102000044209 Tumor Suppressor Genes Human genes 0.000 title abstract 9
- 108700025716 Tumor Suppressor Genes Proteins 0.000 title abstract 9
- 108700028369 Alleles Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 abstract 1
- 102000007079 Peptide Fragments Human genes 0.000 abstract 1
- 108010033276 Peptide Fragments Proteins 0.000 abstract 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 230000030279 gene silencing Effects 0.000 abstract 1
- 238000012226 gene silencing method Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000002853 nucleic acid probe Substances 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
Abstract
The present invention relates generally to the field of cancer therapy and cancer diagnostics and to agents useful therefor. More particularly, the present invention provides a novel tumor suppressor gene, an expression product including a polypeptide or protein encoded thereby and nucleic acid probes and primers and peptide fragments characteristic of the tumor suppressor gene or its expression product or mutants or derivatives thereof. The present invention further provides molecules generated through combinatorial chemistry or rational chemical synthesis or identified following screening of chemical libraries or natural sources which augment or otherwise facilitate the activity or function of the tumor suppressor gene or its expression product and in particular in cells which carry a deletion or other mutation including a gene silencing event in one or both alleles of the tumor suppressor gene. The present invention provides diagnostic agents to detect the presence or absence of the tumor suppressor gene or the presence or absence of an expressible tumor suppressor gene or the presence or absence of an expression product of the tumor suppressor gene useful in determining the likelihood of development of a tumor in a vertebrate animal such as mammal and in particular a human. The present invention further provides genetically modified animals carrying cells in which one or both alleles of the tumor suppressor gene are deleted or mutated or where expression of the gene is otherwise silenced.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003202315A AU2003202315A1 (en) | 2002-02-07 | 2003-02-07 | Lmt tumor suppressor gene |
| US10/512,477 US20050172424A1 (en) | 2002-02-07 | 2003-04-30 | Lmt turmor suppressor gene |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPS0371 | 2002-02-07 | ||
| AUPS0371A AUPS037102A0 (en) | 2002-02-07 | 2002-02-07 | A novel gene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2003066869A1 WO2003066869A1 (en) | 2003-08-14 |
| WO2003066869A8 true WO2003066869A8 (en) | 2004-02-12 |
Family
ID=3833972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/AU2003/000126 WO2003066869A1 (en) | 2002-02-07 | 2003-02-07 | Lmt tumor suppressor gene |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20050172424A1 (en) |
| AU (1) | AUPS037102A0 (en) |
| WO (1) | WO2003066869A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090031582A1 (en) * | 2007-07-30 | 2009-02-05 | Anyi Lu | Shoe with sock lining and elastic collar |
| CN105779572B (en) * | 2014-12-22 | 2020-07-07 | 深圳华大基因研究院 | Chip and method for capturing target sequence of tumor susceptibility gene and mutation detection method |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US757816A (en) * | 1903-12-29 | 1904-04-19 | Gustavus Krieger | Ankle-supporting shoe. |
| US991036A (en) * | 1910-12-13 | 1911-05-02 | Wolf Spiegelman | Shoe. |
| US1717432A (en) * | 1928-07-12 | 1929-06-18 | Michael Brite | Ankle and arch support for children's shoes |
| US3590411A (en) * | 1968-12-26 | 1971-07-06 | Usm Corp | Stiffening processes |
| US4706316A (en) * | 1985-11-27 | 1987-11-17 | Giancarlo Tanzi | Method for producing footwear |
| CA1277135C (en) * | 1986-07-21 | 1990-12-04 | Pierre Charles Lepine | Adjustable inner sole for footwear |
| US5152082A (en) * | 1991-12-16 | 1992-10-06 | Culpepper Thomas C | Shoe and ankle support therefor |
| US5392532A (en) * | 1993-10-18 | 1995-02-28 | R. G. Barry Corporation | Slipper having an insole attached to a peripheral outsole wall |
| US6079128A (en) * | 1993-11-30 | 2000-06-27 | Bauer Nike Hockey Inc. | Skate boot construction with integral plastic insert |
| US6041524A (en) * | 1998-10-05 | 2000-03-28 | Jeffrey S. Brooks, Inc. | Footwear having recessed heel cup |
| US6519877B2 (en) * | 2001-01-12 | 2003-02-18 | K-2 Corporation | Snowboard boot with removable upper support |
-
2002
- 2002-02-07 AU AUPS0371A patent/AUPS037102A0/en not_active Abandoned
-
2003
- 2003-02-07 WO PCT/AU2003/000126 patent/WO2003066869A1/en not_active Application Discontinuation
- 2003-04-30 US US10/512,477 patent/US20050172424A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AUPS037102A0 (en) | 2002-02-28 |
| WO2003066869A1 (en) | 2003-08-14 |
| US20050172424A1 (en) | 2005-08-11 |
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