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WO2003051291A3 - Composes de 5-hydroxy-indole substitues destines au traitement du glaucome - Google Patents

Composes de 5-hydroxy-indole substitues destines au traitement du glaucome Download PDF

Info

Publication number
WO2003051291A3
WO2003051291A3 PCT/US2002/038625 US0238625W WO03051291A3 WO 2003051291 A3 WO2003051291 A3 WO 2003051291A3 US 0238625 W US0238625 W US 0238625W WO 03051291 A3 WO03051291 A3 WO 03051291A3
Authority
WO
WIPO (PCT)
Prior art keywords
glaucoma
hydroxy
substituted
treatment
indole compounds
Prior art date
Application number
PCT/US2002/038625
Other languages
English (en)
Other versions
WO2003051291A2 (fr
Inventor
Jesse A May
Anura P Dantanarayana
Abdelmoula Namil
Najam A Sharif
Paul W Zinke
Thomas R Dean
Original Assignee
Alcon Inc
Jesse A May
Anura P Dantanarayana
Abdelmoula Namil
Najam A Sharif
Paul W Zinke
Thomas R Dean
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc, Jesse A May, Anura P Dantanarayana, Abdelmoula Namil, Najam A Sharif, Paul W Zinke, Thomas R Dean filed Critical Alcon Inc
Priority to AU2002364711A priority Critical patent/AU2002364711A1/en
Publication of WO2003051291A2 publication Critical patent/WO2003051291A2/fr
Publication of WO2003051291A3 publication Critical patent/WO2003051291A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des nouveaux composés présentant une activité agoniste de 5-HT2, des compositions contenant ces composés ainsi que des méthodes d'utilisation correspondantes permettant d'abaisser la pression intraoculaire et/ou d'assurer une neuroprotection.
PCT/US2002/038625 2001-12-14 2002-12-05 Composes de 5-hydroxy-indole substitues destines au traitement du glaucome WO2003051291A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002364711A AU2002364711A1 (en) 2001-12-14 2002-12-05 Substituted 5-hydroxy-indole compounds for the treatment of glaucoma

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34044501P 2001-12-14 2001-12-14
US60/340,445 2001-12-14

Publications (2)

Publication Number Publication Date
WO2003051291A2 WO2003051291A2 (fr) 2003-06-26
WO2003051291A3 true WO2003051291A3 (fr) 2003-10-23

Family

ID=23333383

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038625 WO2003051291A2 (fr) 2001-12-14 2002-12-05 Composes de 5-hydroxy-indole substitues destines au traitement du glaucome

Country Status (2)

Country Link
AU (1) AU2002364711A1 (fr)
WO (1) WO2003051291A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
AU2003300915B2 (en) 2002-12-13 2008-08-28 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
US7476687B2 (en) 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
TW200520760A (en) 2003-12-15 2005-07-01 Alcon Inc Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
CN109172580B (zh) * 2018-09-06 2021-04-27 中山万汉制药有限公司 包含前列腺素衍生物的组合物以及包含该组合物的眼用液体制剂

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571833A (en) * 1991-06-21 1996-11-05 Smithkline Beecham Plc Tryptamine analogues, their synthesis and their use as 5-HT1 -like or 5-HT2 receptor agonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571833A (en) * 1991-06-21 1996-11-05 Smithkline Beecham Plc Tryptamine analogues, their synthesis and their use as 5-HT1 -like or 5-HT2 receptor agonists

Also Published As

Publication number Publication date
AU2002364711A1 (en) 2003-06-30
AU2002364711A8 (en) 2003-06-30
WO2003051291A2 (fr) 2003-06-26

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