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WO2003041495A1 - Animal chimerique - Google Patents

Animal chimerique Download PDF

Info

Publication number
WO2003041495A1
WO2003041495A1 PCT/JP2002/011236 JP0211236W WO03041495A1 WO 2003041495 A1 WO2003041495 A1 WO 2003041495A1 JP 0211236 W JP0211236 W JP 0211236W WO 03041495 A1 WO03041495 A1 WO 03041495A1
Authority
WO
WIPO (PCT)
Prior art keywords
nonhuman animal
chimeric nonhuman
chimeric
desired protein
protein
Prior art date
Application number
PCT/JP2002/011236
Other languages
English (en)
French (fr)
Inventor
Kazuma Tomizuka
Makoto Kakitani
Takashi Yoneya
Isao Ishida
Original Assignee
Kirin Beer Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Beer Kabushiki Kaisha filed Critical Kirin Beer Kabushiki Kaisha
Priority to US10/495,629 priority Critical patent/US20050177884A1/en
Priority to JP2003543395A priority patent/JP4087338B2/ja
Priority to EP02777997A priority patent/EP1452093A4/en
Publication of WO2003041495A1 publication Critical patent/WO2003041495A1/ja
Priority to US12/481,476 priority patent/US20100011452A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PCT/JP2002/011236 2001-11-15 2002-10-29 Animal chimerique WO2003041495A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/495,629 US20050177884A1 (en) 2001-11-15 2002-10-29 Chimeric nonhuman animal
JP2003543395A JP4087338B2 (ja) 2001-11-15 2002-10-29 キメラ非ヒト動物
EP02777997A EP1452093A4 (en) 2001-11-15 2002-10-29 CHIMESE NON-MENTAL ANIMAL
US12/481,476 US20100011452A1 (en) 2001-11-15 2009-06-09 Chimeric non-human animal

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001350481 2001-11-15
JP2001-350481 2001-11-15
JP2002042321 2002-02-19
JP2002-042321 2002-02-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/481,476 Continuation US20100011452A1 (en) 2001-11-15 2009-06-09 Chimeric non-human animal

Publications (1)

Publication Number Publication Date
WO2003041495A1 true WO2003041495A1 (fr) 2003-05-22

Family

ID=26624538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/011236 WO2003041495A1 (fr) 2001-11-15 2002-10-29 Animal chimerique

Country Status (4)

Country Link
US (2) US20050177884A1 (ja)
EP (2) EP1994824A1 (ja)
JP (1) JP4087338B2 (ja)
WO (1) WO2003041495A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006094849A (ja) * 2004-08-30 2006-04-13 Kirin Brewery Co Ltd 相同組換え効率が向上した分化多能性細胞及びその利用
WO2006078072A1 (ja) * 2005-01-21 2006-07-27 Kirin Beer Kabushiki Kaisha キメラ非ヒト動物およびその使用
WO2008013067A1 (fr) 2006-07-07 2008-01-31 Kyowa Hakko Kirin Co., Ltd. Vecteur de chromosome artificiel humain (cah), et substance pharmaceutique à base de cellules humaines contenant un vecteur de chromosome artificiel humain (cah)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
EP1573314B1 (en) * 2002-12-16 2008-07-23 Genentech, Inc. Transgenic mice expressing human cd20
EP1603450A4 (en) 2003-03-07 2009-07-29 Univ Columbia PROCEDURE BASED ON TYPE 1 RYANODIN RECEPTOR
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
WO2010040363A2 (de) 2008-10-07 2010-04-15 Fev Motorentechnik Gmbh Lithium-ionen-batterie
EP4049535B1 (en) * 2009-10-06 2024-11-27 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
DK3375284T3 (da) 2011-02-15 2023-06-12 Univ Yale Humaniserede M-CSF-mus og anvendelser deraf
KR102321909B1 (ko) 2011-10-28 2021-11-05 리제너론 파아마슈티컬스, 인크. 유전자 변형된 ｔ 세포 수용체 마우스
AU2013312359B8 (en) 2012-09-07 2019-08-15 Institute For Research In Biomedicine (Irb) Genetically modified non-human animals and methods of use thereof
DK3556206T3 (da) 2012-11-05 2021-08-09 Regeneron Pharma Genmodificerede ikke-humane dyr og fremgangsmåder til anvendelse deraf
KR102574155B1 (ko) 2014-05-19 2023-09-05 리제너론 파마슈티칼스 인코포레이티드 인간 epo를 발현하는 유전자 변형된 비-인간 동물
LT3280257T (lt) 2015-04-06 2023-09-25 Regeneron Pharmaceuticals, Inc. Imuniniai atsakai gyvūnuose, išskyrus žmogų, tarpininkaujant humanizuotoms t ląstelėms
WO2016168212A1 (en) 2015-04-13 2016-10-20 Regeneron Pharmaceuticals, Inc. Humanized sirpa-il15 knockin mice and methods of use thereof
CA3006465A1 (en) * 2015-10-27 2017-05-04 Recombinetics, Inc. Engineering of humanized car t-cells and platelets by genetic complementation
GB2603289A (en) * 2019-05-21 2022-08-03 Univ Kent State Ohio Animal cell lines for foods containing cultured animal cells
CA3231125A1 (en) 2021-10-19 2023-04-27 Joshua MARCH Plant base/animal cell hybrid meat substitute

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994024301A1 (en) * 1993-04-21 1994-10-27 The University Of Edinburgh Expression of heterologous genes according to a targeted expression profile
JPH08322427A (ja) * 1995-01-19 1996-12-10 Fujita Gakuen トランスジェニック動物においてマークをつけた細胞及び組織を標的とする方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877397A (en) * 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
SG47030A1 (en) 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
DE69636868T2 (de) * 1995-08-29 2007-10-25 Kirin Beer Kabushiki Kaisha Chimäres tier und methode zu dessen herstellung
DE19632532A1 (de) * 1996-08-13 1998-02-19 Boehringer Ingelheim Int Verfahren zur Herstellung von Säugetieren mit definierten genetischen Eigenschaften
TWI255853B (en) 1998-08-21 2006-06-01 Kirin Brewery Method for modifying chromosomes
JP4016575B2 (ja) 2000-06-09 2007-12-05 セイコーエプソン株式会社 データ管理装置、データ管理プログラムを記憶した記憶媒体、利用証データを記憶した記憶媒体及びデータ利用方法
JP2002042321A (ja) 2000-07-26 2002-02-08 Tdk Corp 磁気記録媒体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994024301A1 (en) * 1993-04-21 1994-10-27 The University Of Edinburgh Expression of heterologous genes according to a targeted expression profile
JPH08322427A (ja) * 1995-01-19 1996-12-10 Fujita Gakuen トランスジェニック動物においてマークをつけた細胞及び組織を標的とする方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEN J. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 4528 - 4532, XP002962993 *
LIEGEOIS N.J. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, no. 1, 1996, pages 1303 - 1307, XP002962991 *
See also references of EP1452093A4 *
SLECKMAN B.P. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 7975 - 7980, XP002962992 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006094849A (ja) * 2004-08-30 2006-04-13 Kirin Brewery Co Ltd 相同組換え効率が向上した分化多能性細胞及びその利用
WO2006078072A1 (ja) * 2005-01-21 2006-07-27 Kirin Beer Kabushiki Kaisha キメラ非ヒト動物およびその使用
WO2008013067A1 (fr) 2006-07-07 2008-01-31 Kyowa Hakko Kirin Co., Ltd. Vecteur de chromosome artificiel humain (cah), et substance pharmaceutique à base de cellules humaines contenant un vecteur de chromosome artificiel humain (cah)

Also Published As

Publication number Publication date
US20050177884A1 (en) 2005-08-11
EP1994824A1 (en) 2008-11-26
EP1452093A4 (en) 2007-08-15
JP4087338B2 (ja) 2008-05-21
EP1452093A1 (en) 2004-09-01
US20100011452A1 (en) 2010-01-14
JPWO2003041495A1 (ja) 2005-03-03

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