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WO2002030952A3 - Haplotypes du gene cyp27a1 - Google Patents

Haplotypes du gene cyp27a1 Download PDF

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Publication number
WO2002030952A3
WO2002030952A3 PCT/US2001/042727 US0142727W WO0230952A3 WO 2002030952 A3 WO2002030952 A3 WO 2002030952A3 US 0142727 W US0142727 W US 0142727W WO 0230952 A3 WO0230952 A3 WO 0230952A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
cyp27a1
gene
disclosed
cyp27a1 gene
Prior art date
Application number
PCT/US2001/042727
Other languages
English (en)
Other versions
WO2002030952A2 (fr
Inventor
Alison E Anastasio
Anne Chew
Jin-Hua Han
Angela Sanchis
Original Assignee
Genaissance Pharmaceuticals
Alison E Anastasio
Anne Chew
Jin-Hua Han
Angela Sanchis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Alison E Anastasio, Anne Chew, Jin-Hua Han, Angela Sanchis filed Critical Genaissance Pharmaceuticals
Priority to AU2002213489A priority Critical patent/AU2002213489A1/en
Publication of WO2002030952A2 publication Critical patent/WO2002030952A2/fr
Publication of WO2002030952A3 publication Critical patent/WO2002030952A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne de nouveaux variants génétiques du gène (CYP27A1) du Cytochrome P450, sous-famille XXVIIA (Stéroïde 27-Hydroxylase, Cerebrotendinous Xanthomatosis), polypeptide 1. Elle concerne également divers génotypes, haplotypes, et paires d'haplotypes du gène CYP27A1 existants dans la population générale des Etats-Unis. L'invention concerne en outre des compositions et des méthodes d'haplotypage et/ou de génotypage du gène CYP27A1 chez un individu. Elle concerne enfin des polynucléotides définis par les haplotypes de l'invention.
PCT/US2001/042727 2000-10-13 2001-10-15 Haplotypes du gene cyp27a1 WO2002030952A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002213489A AU2002213489A1 (en) 2000-10-13 2001-10-15 Haplotypes of the cyp27a1 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23994200P 2000-10-13 2000-10-13
US60/239,942 2000-10-13

Publications (2)

Publication Number Publication Date
WO2002030952A2 WO2002030952A2 (fr) 2002-04-18
WO2002030952A3 true WO2002030952A3 (fr) 2002-09-06

Family

ID=22904417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/042727 WO2002030952A2 (fr) 2000-10-13 2001-10-15 Haplotypes du gene cyp27a1

Country Status (2)

Country Link
AU (1) AU2002213489A1 (fr)
WO (1) WO2002030952A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CALI ET AL.: "Mutations of the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 12, April 1991 (1991-04-01), pages 7779 - 7783, XP002921850 *
DATABASE GENBANK [online] NATIONAL LIBRARY OF MEDICINE, NIH (BETHESDA, MD, USA); 17 June 2000 (2000-06-17), WATERSTON, R.H.: "Nucleotide sequences", XP002951195, accession no. NCBI Database accession no. (AC009974) *

Also Published As

Publication number Publication date
WO2002030952A2 (fr) 2002-04-18
AU2002213489A1 (en) 2002-04-22

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