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WO2002046209A3 - Haplotypes du gene cyp3a5 - Google Patents

Haplotypes du gene cyp3a5 Download PDF

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Publication number
WO2002046209A3
WO2002046209A3 PCT/US2001/047218 US0147218W WO0246209A3 WO 2002046209 A3 WO2002046209 A3 WO 2002046209A3 US 0147218 W US0147218 W US 0147218W WO 0246209 A3 WO0246209 A3 WO 0246209A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
cyp3a5
gene
disclosed
cyp3a5 gene
Prior art date
Application number
PCT/US2001/047218
Other languages
English (en)
Other versions
WO2002046209A2 (fr
Inventor
Alison E Anastasio
Jin-Hua Han
Stefanie E Kliem
Eileen Rounds
Original Assignee
Genaissance Pharmaceuticals
Alison E Anastasio
Jin-Hua Han
Stefanie E Kliem
Eileen Rounds
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Alison E Anastasio, Jin-Hua Han, Stefanie E Kliem, Eileen Rounds filed Critical Genaissance Pharmaceuticals
Priority to AU2002236581A priority Critical patent/AU2002236581A1/en
Publication of WO2002046209A2 publication Critical patent/WO2002046209A2/fr
Publication of WO2002046209A3 publication Critical patent/WO2002046209A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des variantes du gène polypeptide 5 (CYP3A5) du cytochrome P450, sous-famille IIIA. La présente invention porte également sur divers génotypes, haplotypes et des paires d'haplotypes existant en règle générale dans la population des Etats-Unis, relativement au gène CYP3A5. Cette invention concerne aussi des compositions et des procédés d'haplotypage et/ou de génotypage du gène CYP3A5 chez un individu, ainsi que des polynucléotides définies par les haplotypes susmentionnés.
PCT/US2001/047218 2000-12-08 2001-12-07 Haplotypes du gene cyp3a5 WO2002046209A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002236581A AU2002236581A1 (en) 2000-12-08 2001-12-07 Haplotypes of the cyp3a5 gene

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25436700P 2000-12-08 2000-12-08
US60/254,367 2000-12-08
US28847001P 2001-05-03 2001-05-03
US60/288,470 2001-05-03

Publications (2)

Publication Number Publication Date
WO2002046209A2 WO2002046209A2 (fr) 2002-06-13
WO2002046209A3 true WO2002046209A3 (fr) 2003-09-04

Family

ID=26944013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047218 WO2002046209A2 (fr) 2000-12-08 2001-12-07 Haplotypes du gene cyp3a5

Country Status (2)

Country Link
AU (1) AU2002236581A1 (fr)
WO (1) WO2002046209A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022475B2 (en) * 2001-03-29 2006-04-04 St. Jude Children's Research Hospital Genotyping assay to predict CYP3A5 phenotype
JP5592802B2 (ja) * 2008-01-25 2014-09-17 セラノスティクス ラボラトリー 薬物応答を評価するための方法および組成物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AOYAMA ET AL.: "Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentialy expressed in adult human liver", J. OF BIOL. CHEM., vol. 264, no. 18, 1989, pages 10388 - 10395, XP002909958 *
JOUNAIDI ET AL.: "Detection of a CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein", BIOCHEM. AND BIOPHYS. RESEARCH COMM., vol. 221, 1996, pages 466 - 470, XP002961263 *
MACLEOD ET AL.: "Cancer therapy and polymorphisms of cytochromes P450", CLIN. CHEM. LAB. MED., vol. 38, no. 9, 2000, pages 883 - 887, XP002961947 *
SMITH ET AL.: "Molecular genetics of the human cytochrome P450 monooxygenase superfamily", XENOBIOTICA, vol. 28, no. 12, 1998, pages 1129 - 1165, XP002930143 *

Also Published As

Publication number Publication date
WO2002046209A2 (fr) 2002-06-13
AU2002236581A1 (en) 2002-06-18

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