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WO2002018321A3 - Inhibiteurs de proteine tyrosine phosphatase d'acide amino(oxo)acetique - Google Patents

Inhibiteurs de proteine tyrosine phosphatase d'acide amino(oxo)acetique Download PDF

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Publication number
WO2002018321A3
WO2002018321A3 PCT/US2001/026133 US0126133W WO0218321A3 WO 2002018321 A3 WO2002018321 A3 WO 2002018321A3 US 0126133 W US0126133 W US 0126133W WO 0218321 A3 WO0218321 A3 WO 0218321A3
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Prior art keywords
protein tyrosine
oxo
amino
acetic acid
tyrosine phosphatase
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PCT/US2001/026133
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English (en)
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WO2002018321A2 (fr
Inventor
Gang Liu
Yihong Li
David A Janowick
Zhonghua Pei
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Abbott Lab
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Publication of WO2002018321A2 publication Critical patent/WO2002018321A2/fr
Publication of WO2002018321A3 publication Critical patent/WO2002018321A3/fr

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    • C07—ORGANIC CHEMISTRY
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07C233/00—Carboxylic acid amides
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    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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Abstract

L'invention concerne des composés de formule (I), y compris les sels thérapeutiquement acceptables correspondants, qui sont des inhibiteurs de protéine tyrosine kinase PTP1B. L'invention concerne également l'élaboration des composés considérés, différentes compositions renfermant ce type de composé, et le traitement de maladies par le biais de tels composés.
PCT/US2001/026133 2000-08-29 2001-08-21 Inhibiteurs de proteine tyrosine phosphatase d'acide amino(oxo)acetique WO2002018321A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65092300A 2000-08-29 2000-08-29
US09/650,923 2000-08-29

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Publication Number Publication Date
WO2002018321A2 WO2002018321A2 (fr) 2002-03-07
WO2002018321A3 true WO2002018321A3 (fr) 2003-04-10

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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04007253A (es) * 2002-01-29 2004-10-29 Applied Research Systems Derivados de metilenamidas sustituidos como moduladores de proteina tirosina fosfatasas (ptp).
US7247741B2 (en) 2005-01-21 2007-07-24 Ptc Therapeutics, Inc. Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease
WO2004009533A1 (fr) * 2002-07-24 2004-01-29 Ptc Therapeutics, Inc. Composes d'acide acetylamino benzoique et leur utilisation pour la suppression de non-sens et le traitement de maladie
CL2004000541A1 (es) * 2003-03-31 2005-02-04 Warner Lambert Co Procedimiento de preparacion de clorhidrato de quinapril por reaccion entre una 2,5-dioxo-oxazolidina y un ester terbutilico de una tetrahidro isoquinolina, util como principio activo para tratar la hipertension y la insuficiencia cardiaca congestiva
AU2004261400A1 (en) 2003-07-21 2005-02-10 Laboratoires Serono Sa Alkynyl aryl carboxamides
WO2005035551A2 (fr) 2003-10-08 2005-04-21 Incyte Corporation Inhibiteurs de proteines se liant a des molecules phosphorylees
TW200602337A (en) 2004-02-25 2006-01-16 Wyeth Corp Inhibitors of protein tyrosine phosphatase 1B
BRPI0513405A (pt) 2004-07-16 2008-05-06 Sunesis Pharmaceuticals Inc tienopirimidinas úteis como inibidores de aurora quinase
CN101260086B (zh) * 2007-03-06 2011-08-10 中国科学院上海药物研究所 蛋白酪氨酸磷酸酯酶1b抑制剂及其制备方法和用途
WO2015134357A1 (fr) * 2014-03-03 2015-09-11 Emory University Modulateurs du récepteur de l'insuline
CN106748998A (zh) * 2015-03-12 2017-05-31 佛山市赛维斯医药科技有限公司 一种含烟酸酰胺结构的ptp1b抑制剂及其用途
CN104761540A (zh) * 2015-03-12 2015-07-08 佛山市赛维斯医药科技有限公司 一种含烟酸酰胺和哌啶结构的化合物及其用途
CN106831561A (zh) * 2015-03-12 2017-06-13 佛山市赛维斯医药科技有限公司 一种含烟酸酰胺和苯胺结构的ptp1b抑制剂、其制备及用途
CN104725307A (zh) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 一种含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途
CN104725353A (zh) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 一类含烟酸酰胺和哌啶结构ptp1b抑制剂及其用途
CN106748999A (zh) * 2015-03-12 2017-05-31 佛山市赛维斯医药科技有限公司 一类含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途
CN104725355A (zh) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 一种含烟酸酰胺和哌啶结构ptp1b抑制剂及其用途
CN106831562A (zh) * 2015-03-12 2017-06-13 佛山市赛维斯医药科技有限公司 含烟酸酰胺结构的ptp1b抑制剂及其用途
CN104725310A (zh) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 一种含烟酸酰胺和苯胺结构的ptp1b抑制剂及其用途
CN106866523A (zh) * 2015-03-12 2017-06-20 佛山市赛维斯医药科技有限公司 含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途
CN106883211A (zh) * 2015-03-12 2017-06-23 佛山市赛维斯医药科技有限公司 一类含烟酸酰胺和哌啶结构化合物及其用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3836541A (en) * 1972-09-27 1974-09-17 Upjohn Co 3-cyano-2-pyrryl oxamic acids
WO1993015044A1 (fr) * 1992-01-29 1993-08-05 Smithkline Beecham Corporation Derives d'acide n-benzyloxamique, d'oxamate et d'oxamide et leur utilisation comme inhibiteurs du facteur de necrose tumorale (fnt) et de la phosphodiesterase iv (pde iv)
US5532267A (en) * 1992-02-10 1996-07-02 Torii & Co., Ltd. Amidinonaphthyl furancarboxylate derivatives and acid addition salts therof
WO1999046267A1 (fr) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulateurs de proteine tyrosine phosphatases (ptpases)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3836541A (en) * 1972-09-27 1974-09-17 Upjohn Co 3-cyano-2-pyrryl oxamic acids
WO1993015044A1 (fr) * 1992-01-29 1993-08-05 Smithkline Beecham Corporation Derives d'acide n-benzyloxamique, d'oxamate et d'oxamide et leur utilisation comme inhibiteurs du facteur de necrose tumorale (fnt) et de la phosphodiesterase iv (pde iv)
US5532267A (en) * 1992-02-10 1996-07-02 Torii & Co., Ltd. Amidinonaphthyl furancarboxylate derivatives and acid addition salts therof
WO1999046267A1 (fr) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulateurs de proteine tyrosine phosphatases (ptpases)

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002224849, Database accession no. 7044775 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002224850, Database accession no. 7490376 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002224851, Database accession no. 2732230 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002224852, Database accession no. 2732219 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002224853, Database accession no. 5045520 *
GODEFROI ET AL, JOURNAL OF ORGANIC CHEMISTRY., vol. 32, 1967, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, pages 1259, ISSN: 0022-3263 *
GODFROI ET AL, JOURNAL OF ORGANIC CHEMISTRY., vol. 32, 1967, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, pages 1259, ISSN: 0022-3263 *
HENNEUSE, C ET AL, SYNTHESIS., vol. 4, 1996, GEORG THIEME VERLAG. STUTTGART., DE, pages 495 - 501, ISSN: 0039-7881 *
KLAUBERT, D H ET AL, JOURNAL OF MEDICINAL CHEMISTRY., vol. 24, no. 6, 1981, AMERICAN CHEMICAL SOCIETY., US, pages 748 - 752, ISSN: 0022-2623 *
RAULT, I ET AL, HETEROCYCLES., vol. 38, no. 4, 1994, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM., NL, pages 811 - 818, ISSN: 0385-5414 *

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