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WO2002018321A3 - Amino(oxo)acetic acid protein tyrosine phosphatase inhibitors - Google Patents

Amino(oxo)acetic acid protein tyrosine phosphatase inhibitors Download PDF

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Publication number
WO2002018321A3
WO2002018321A3 PCT/US2001/026133 US0126133W WO0218321A3 WO 2002018321 A3 WO2002018321 A3 WO 2002018321A3 US 0126133 W US0126133 W US 0126133W WO 0218321 A3 WO0218321 A3 WO 0218321A3
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WO
WIPO (PCT)
Prior art keywords
protein tyrosine
oxo
amino
acetic acid
tyrosine phosphatase
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PCT/US2001/026133
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French (fr)
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WO2002018321A2 (en
Inventor
Gang Liu
Yihong Li
David A Janowick
Zhonghua Pei
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Abbott Lab
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Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of WO2002018321A2 publication Critical patent/WO2002018321A2/en
Publication of WO2002018321A3 publication Critical patent/WO2002018321A3/en

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
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    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
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    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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Abstract

Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
PCT/US2001/026133 2000-08-29 2001-08-21 Amino(oxo)acetic acid protein tyrosine phosphatase inhibitors WO2002018321A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65092300A 2000-08-29 2000-08-29
US09/650,923 2000-08-29

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WO2002018321A2 WO2002018321A2 (en) 2002-03-07
WO2002018321A3 true WO2002018321A3 (en) 2003-04-10

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US7247741B2 (en) 2005-01-21 2007-07-24 Ptc Therapeutics, Inc. Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease
WO2004009533A1 (en) * 2002-07-24 2004-01-29 Ptc Therapeutics, Inc. Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease
CL2004000541A1 (en) * 2003-03-31 2005-02-04 Warner Lambert Co PROCEDURE FOR PREPARATION OF QUINAPRIL CHLORHYDRATE BY REACTION BETWEEN A 2,5-DIOXO-OXAZOLIDINE AND A TERBUTILIC ESTER OF AN ISOQUINOLINE TETRAHYDRA, USED AS AN ACTIVE PRINCIPLE TO TREAT HYGERTENSION AND CARDIAC INSUFFICIENCY
EP1654247B1 (en) * 2003-07-21 2010-01-20 Merck Serono SA Alkynyl aryl carboxamides
US7141596B2 (en) 2003-10-08 2006-11-28 Incyte Corporation Inhibitors of proteins that bind phosphorylated molecules
US7521473B2 (en) 2004-02-25 2009-04-21 Wyeth Inhibitors of protein tyrosine phosphatase 1B
EP1768984B1 (en) 2004-07-16 2010-10-20 Sunesis Pharmaceuticals, Inc. Thienopyrimidines useful as aurora kinase inhibitors
CN101260086B (en) * 2007-03-06 2011-08-10 中国科学院上海药物研究所 Protein-tyrosine-phosphatase 1B inhibitor and its preparation method and use
WO2015134357A1 (en) * 2014-03-03 2015-09-11 Emory University Modulators of insulin receptor
CN106866523A (en) * 2015-03-12 2017-06-20 佛山市赛维斯医药科技有限公司 PTP1B inhibitor, preparation method and its usage containing niacin hydroxyacyl amine structure
CN104761540A (en) * 2015-03-12 2015-07-08 佛山市赛维斯医药科技有限公司 Compound containing structures of nicotinamide and piperidine and application thereof
CN104725307A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide structure and preparation method and use thereof
CN104725353A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide and piperidine structures and use thereof
CN104725306A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide structure and preparation method and use thereof
CN106748998A (en) * 2015-03-12 2017-05-31 佛山市赛维斯医药科技有限公司 A kind of PTP1B inhibitor containing niacin hydroxyacyl amine structure and application thereof
CN104725312A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide and aniline structures and preparation method and use thereof
CN106831560A (en) * 2015-03-12 2017-06-13 佛山市赛维斯医药科技有限公司 A kind of PTP1B inhibitor containing niacin hydroxyacyl amine and aniline structure and application thereof
CN104725355A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide and piperidine structures and use thereof
CN104725354A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 Compound containing nicotinic acid amide and piperidine structures and use thereof
CN104725311A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide structure and use thereof

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