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WO2002018363A3 - 3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors - Google Patents

3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors Download PDF

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Publication number
WO2002018363A3
WO2002018363A3 PCT/US2001/026356 US0126356W WO0218363A3 WO 2002018363 A3 WO2002018363 A3 WO 2002018363A3 US 0126356 W US0126356 W US 0126356W WO 0218363 A3 WO0218363 A3 WO 0218363A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein tyrosine
phenyl
acid derivatives
propanoic acid
tyrosine phosphatase
Prior art date
Application number
PCT/US2001/026356
Other languages
French (fr)
Other versions
WO2002018363A2 (en
Inventor
Gang Liu
Zhong Hua Pei
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of WO2002018363A2 publication Critical patent/WO2002018363A2/en
Publication of WO2002018363A3 publication Critical patent/WO2002018363A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
PCT/US2001/026356 2000-08-29 2001-08-23 3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors WO2002018363A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65092400A 2000-08-29 2000-08-29
US09/650,924 2000-08-29

Publications (2)

Publication Number Publication Date
WO2002018363A2 WO2002018363A2 (en) 2002-03-07
WO2002018363A3 true WO2002018363A3 (en) 2002-06-27

Family

ID=24610852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026356 WO2002018363A2 (en) 2000-08-29 2001-08-23 3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors

Country Status (1)

Country Link
WO (1) WO2002018363A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106542A1 (en) 2003-05-29 2004-12-09 Sankyo Company, Limited Insulin resistance curative and method of screening the same
US7582773B2 (en) * 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
WO2005035551A2 (en) 2003-10-08 2005-04-21 Incyte Corporation Inhibitors of proteins that bind phosphorylated molecules
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2970177A1 (en) 2013-03-15 2016-01-20 Pfizer Inc. Indole compounds that activate ampk

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0455006A2 (en) * 1990-05-04 1991-11-06 American Cyanamid Company Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
WO1999046268A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)
WO1999046236A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO1999046267A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO1999058518A2 (en) * 1998-05-12 1999-11-18 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
WO1999061435A1 (en) * 1998-05-12 1999-12-02 American Home Products Corporation Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia
WO1999061410A1 (en) * 1998-05-12 1999-12-02 American Home Products Corporation 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0455006A2 (en) * 1990-05-04 1991-11-06 American Cyanamid Company Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
WO1999046268A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)
WO1999046236A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO1999046267A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO1999058518A2 (en) * 1998-05-12 1999-11-18 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
WO1999061435A1 (en) * 1998-05-12 1999-12-02 American Home Products Corporation Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia
WO1999061410A1 (en) * 1998-05-12 1999-12-02 American Home Products Corporation 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MALAMAS,M.S. ET AL.: "Novel Benzofuran and Benzothiophene Biphenyls as Inhibitors of Protein Tyrosine Phophatase 1B with Antihyperglycemic Properites", J.MED.CHEM., vol. 43, no. 7, 6 April 2000 (2000-04-06), WASHINGTON, pages 1293 - 1310, XP002190818 *
WROBEL JAY ET AL: "PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo(b) naphtho(2,3-d)furans and 11-arylbenzo(b) naphtho(2,3-d)thiophenes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 17, 26 August 1999 (1999-08-26), pages 3199 - 3202, XP002181876, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
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