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WO2002016635A3 - Procede pour le marquage de substances chimiques - Google Patents

Procede pour le marquage de substances chimiques Download PDF

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Publication number
WO2002016635A3
WO2002016635A3 PCT/DE2001/003009 DE0103009W WO0216635A3 WO 2002016635 A3 WO2002016635 A3 WO 2002016635A3 DE 0103009 W DE0103009 W DE 0103009W WO 0216635 A3 WO0216635 A3 WO 0216635A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemical substances
receptor
marking
nucleic acid
chemical substance
Prior art date
Application number
PCT/DE2001/003009
Other languages
German (de)
English (en)
Other versions
WO2002016635A2 (fr
Inventor
Gerhard Hartwich
Michael Bandilla
Original Assignee
Friz Biochem Gmbh
Gerhard Hartwich
Michael Bandilla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friz Biochem Gmbh, Gerhard Hartwich, Michael Bandilla filed Critical Friz Biochem Gmbh
Priority to EP01971604A priority Critical patent/EP1334208A2/fr
Publication of WO2002016635A2 publication Critical patent/WO2002016635A2/fr
Publication of WO2002016635A3 publication Critical patent/WO2002016635A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un procédé pour le marquage et la détection de substances chimiques qui se lient spécifiquement à un récepteur. Selon l'invention, la séquence d'un simple brin d'oligomère d'ADN, d'ARN ou de PNA sert de marquage moléculaire non équivoque appliqué au récepteur correspondant. Après séparation des complexes constitués de la substance chimique et de l'unité oligomère d'acide nucléique récepteur, le constituant oligomère d'acide nucléique et non la substance chimique est identifié et quantifié.
PCT/DE2001/003009 2000-08-25 2001-08-04 Procede pour le marquage de substances chimiques WO2002016635A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP01971604A EP1334208A2 (fr) 2000-08-25 2001-08-04 Procede pour le marquage de substances chimiques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2000141766 DE10041766A1 (de) 2000-08-25 2000-08-25 Verfahren zur Markierung chemischer Substanzen
DE10041766.3 2000-08-25

Publications (2)

Publication Number Publication Date
WO2002016635A2 WO2002016635A2 (fr) 2002-02-28
WO2002016635A3 true WO2002016635A3 (fr) 2003-06-05

Family

ID=7653758

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/003009 WO2002016635A2 (fr) 2000-08-25 2001-08-04 Procede pour le marquage de substances chimiques

Country Status (3)

Country Link
EP (1) EP1334208A2 (fr)
DE (1) DE10041766A1 (fr)
WO (1) WO2002016635A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10156329A1 (de) * 2001-07-17 2003-02-06 Frieder Breitling Verfahren und Anordnung zum Anbringen von in Transportmittel immobilisierten Substanzen sowie Monomerpartikel
DE10200374A1 (de) * 2002-01-08 2003-07-24 Friz Biochem Gmbh Verfahren zur qualitativ und quantitativ vergleichenden Detektion chemischer Substanzen
US7341837B2 (en) * 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
CA2571431A1 (fr) * 2004-06-24 2006-01-05 The Scripps Research Institute Reseaux de liants clivables
CZ2014527A3 (cs) * 2014-08-05 2016-02-17 Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. Způsob detekce aktivní formy analytů ve vzorku a stanovení schopnosti dalších látek vázat se do aktivních míst těchto analytů
CN112834736B (zh) * 2020-12-02 2024-09-06 杭州百凌生物科技有限公司 一种检测多种抗原的病理检测试剂盒及其制备方法和应用
CN115436622B (zh) * 2022-09-26 2024-03-08 重庆医科大学国际体外诊断研究院 一种单分子蛋白的检测方法及其试剂盒和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0314904A1 (fr) * 1987-09-24 1989-05-10 MERCK PATENT GmbH Méthode et réactif pour exécuter des réactions d'hybridations
EP0530998A1 (fr) * 1991-08-15 1993-03-10 Microgenics Corporation Détection de sequences nucléotidiques complémentaires
WO1996032640A1 (fr) * 1995-04-04 1996-10-17 Chiron Diagnostics Corporation Dosages immunologiques de haute precision dans lesquels on utilise des conjugues d'anticorps comprenant des matrices d'adn replicables
US5665539A (en) * 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
US5985548A (en) * 1993-02-04 1999-11-16 E. I. Du Pont De Nemours And Company Amplification of assay reporters by nucleic acid replication
WO1999063109A1 (fr) * 1998-06-04 1999-12-09 Baxter Aktiengesellschaft Procede permettant de determiner des antigenes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748111A (en) * 1984-03-12 1988-05-31 Molecular Diagnostics, Inc. Nucleic acid-protein conjugate used in immunoassay
US5635602A (en) * 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
CA2373047A1 (fr) * 1999-06-01 2000-12-07 Phylos, Inc. Procedes de production de conjugats de 5'-acide nucleique-proteine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0314904A1 (fr) * 1987-09-24 1989-05-10 MERCK PATENT GmbH Méthode et réactif pour exécuter des réactions d'hybridations
US5665539A (en) * 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
EP0530998A1 (fr) * 1991-08-15 1993-03-10 Microgenics Corporation Détection de sequences nucléotidiques complémentaires
US5985548A (en) * 1993-02-04 1999-11-16 E. I. Du Pont De Nemours And Company Amplification of assay reporters by nucleic acid replication
WO1996032640A1 (fr) * 1995-04-04 1996-10-17 Chiron Diagnostics Corporation Dosages immunologiques de haute precision dans lesquels on utilise des conjugues d'anticorps comprenant des matrices d'adn replicables
WO1999063109A1 (fr) * 1998-06-04 1999-12-09 Baxter Aktiengesellschaft Procede permettant de determiner des antigenes

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ASLAM, MOHAMMED: "Bioconjugation", 1998, NYCOMED AMERSHAM, LONDON, UK *
CASE MARIAN C ET AL: "Enhanced ultrasensitive detection of structurally diverse antigens using a single immuno-PCR assay protocol.", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 223, no. 1, 1 February 1999 (1999-02-01), pages 93 - 106, XP002234679, ISSN: 0022-1759 *
CHEMICAL ABSTRACTS, vol. 125, no. 25, 1996, Columbus, Ohio, US; abstract no. 318836z, VARY, CALVIN P.H.: "Nonisotopic DNA labelling strategies" XP008014182 *
CHEMICAL ABSTRACTS, vol. 130, no. 19, 1998, Columbus, Ohio, US; abstract no. 248388z, SIMMONDS, A., CUNNINGHAM, M.: "The preparation of protein-nucleic acid conjugates" XP008014161 *
DANGLER, CHARLES A.: "Nucleic Acid Analysis", 1996, WILEY, NEW YORK, N.Y. *
HENDRICKSON EDWIN R ET AL: "High sensitivity multianalyte immunoassay using covalent DNA-labeled antibodies and polymerase chain reaction", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 23, no. 3, 1995, pages 522 - 529, XP002151883, ISSN: 0305-1048 *
JOERGER R D ET AL: "ANALYTE DETECTION WITH DNA-LABELED ANTIBODIES AND POLYMERASE CHAIN REACTION", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY. WINSTON, US, vol. 41, no. 9, September 1995 (1995-09-01), pages 1371 - 1377, XP001018334, ISSN: 0009-9147 *
NIEMEYER CHRISTOF M ET AL: "Self-assembly of DNA-streptavidin nanostructures and their use as reagents in immuno-PCR.", NUCLEIC ACIDS RESEARCH, vol. 27, no. 23, 1 December 1999 (1999-12-01), pages 4553 - 4561, XP002176567, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
WO2002016635A2 (fr) 2002-02-28
EP1334208A2 (fr) 2003-08-13
DE10041766A1 (de) 2002-03-14

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