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WO2002004520A3 - Transporters and ion channels - Google Patents

Transporters and ion channels Download PDF

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Publication number
WO2002004520A3
WO2002004520A3 PCT/US2001/021448 US0121448W WO0204520A3 WO 2002004520 A3 WO2002004520 A3 WO 2002004520A3 US 0121448 W US0121448 W US 0121448W WO 0204520 A3 WO0204520 A3 WO 0204520A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion channels
trich
transporters
provides
polynucleotides
Prior art date
Application number
PCT/US2001/021448
Other languages
French (fr)
Other versions
WO2002004520A2 (en
Inventor
Brigitte E Raumann
Michael Thornton
Li Ding
Henry Yue
Y Tom Tang
Lee Harland
Neil Burford
Barrie D Greene
Madhu S Sanjanwala
Mariah R Baughn
Original Assignee
Incyte Genomics Inc
Brigitte E Raumann
Michael Thornton
Li Ding
Henry Yue
Y Tom Tang
Lee Harland
Neil Burford
Barrie D Greene
Madhu S Sanjanwala
Mariah R Baughn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Brigitte E Raumann, Michael Thornton, Li Ding, Henry Yue, Y Tom Tang, Lee Harland, Neil Burford, Barrie D Greene, Madhu S Sanjanwala, Mariah R Baughn filed Critical Incyte Genomics Inc
Priority to EP01952496A priority Critical patent/EP1313854A2/en
Priority to CA002415808A priority patent/CA2415808A1/en
Priority to US10/332,447 priority patent/US20040053258A1/en
Priority to AU2001273239A priority patent/AU2001273239A1/en
Priority to JP2002509382A priority patent/JP2004513618A/en
Publication of WO2002004520A2 publication Critical patent/WO2002004520A2/en
Publication of WO2002004520A3 publication Critical patent/WO2002004520A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.
PCT/US2001/021448 2000-07-07 2001-07-05 Transporters and ion channels WO2002004520A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01952496A EP1313854A2 (en) 2000-07-07 2001-07-05 Transporters and ion channels
CA002415808A CA2415808A1 (en) 2000-07-07 2001-07-05 Transporters and ion channels
US10/332,447 US20040053258A1 (en) 2001-07-05 2001-07-05 Transporters and ion channels
AU2001273239A AU2001273239A1 (en) 2000-07-07 2001-07-05 Transporters and ion channels
JP2002509382A JP2004513618A (en) 2000-07-07 2001-07-05 Transporters and ion channels

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US21654700P 2000-07-07 2000-07-07
US60/216,547 2000-07-07
US21823200P 2000-07-14 2000-07-14
US60/218,232 2000-07-14
US22011200P 2000-07-21 2000-07-21
US60/220,112 2000-07-21
US22183900P 2000-07-28 2000-07-28
US60/221,839 2000-07-28

Publications (2)

Publication Number Publication Date
WO2002004520A2 WO2002004520A2 (en) 2002-01-17
WO2002004520A3 true WO2002004520A3 (en) 2003-03-20

Family

ID=27499045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021448 WO2002004520A2 (en) 2000-07-07 2001-07-05 Transporters and ion channels

Country Status (5)

Country Link
EP (1) EP1313854A2 (en)
JP (1) JP2004513618A (en)
AU (1) AU2001273239A1 (en)
CA (1) CA2415808A1 (en)
WO (1) WO2002004520A2 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030236389A1 (en) * 2000-12-15 2003-12-25 Shimkets Richard A. Proteins, polynucleotides encoding them and methods of using the same
US6586179B1 (en) * 1999-07-13 2003-07-01 Icagen, Incorporated Human Eag2
AU2001241446A1 (en) * 2000-02-03 2001-08-14 Lexicon Genetics Incorporated Human transporter proteins and polynucleotides encoding the same
US20020042100A1 (en) * 2000-07-03 2002-04-11 Chunhua Yan Isolated human ion channel proteins, nucleic acid molecules encoding human ion channel proteins, and uses thereof
WO2002024744A2 (en) * 2000-09-25 2002-03-28 Millennium Pharmaceuticals, Inc. 49938, a human phospholipid transporter and uses therefor
GB2372503A (en) * 2000-10-19 2002-08-28 Glaxo Group Ltd Voltage-gated potassium channel polypeptides
WO2002040674A2 (en) * 2000-11-14 2002-05-23 Millenium Pharmaceuticals, Inc. '67118', '67067' and '62092', human proteins and methods of use thereof
JP2004535760A (en) * 2000-11-20 2004-12-02 メルク　エンド　カムパニー　インコーポレーテッド Human ERG2 potassium channel
US20020103337A1 (en) * 2000-12-04 2002-08-01 Chunhua Yan Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
UA79927C2 (en) * 2000-12-05 2007-08-10 Serono Genetics Inst Sa Polynucleotide, coding a polypeptide of potential-depending portal ionic human channel (canion), polypeptyde, antibody, method for identification of candidate modulator of canion-polypeptyde, method for treatment of bipolar disorder or schizophrenia and use of an antibody for production of drugs for treatment of schizophrenia or bipolar disorder
JP2005501505A (en) * 2000-12-12 2005-01-20 ピーイー コーポレイション （エヌワイ） Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and methods of use thereof
EP1358196A4 (en) * 2000-12-20 2004-11-03 Merck & Co Inc Human hyperpolarization-activated cyclic nucleotide-gated cation channel hcn3
JP3997912B2 (en) * 2000-12-27 2007-10-24 アステラス製薬株式会社 New potassium channel
EP1353951A1 (en) * 2001-01-22 2003-10-22 PE Corporation (NY) Isolated human transporter protein, nucleic acid molecules encoding human transporter protein, and uses thereof
EP1273660A3 (en) * 2001-01-30 2004-01-07 Aeomica, Inc. Human sodium-hydrogen exchanger like protein 1
GB2390093A (en) * 2001-01-30 2003-12-31 Aeomica Inc Human sodium-hydrogen exchanger like protein 1
US20020142378A1 (en) * 2001-03-21 2002-10-03 Hongyu Zhang Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
GB2377445A (en) * 2001-04-20 2003-01-15 Smithkline Beecham Plc Ion channel vanilloid receptor, VANILREP7
EP1258496A1 (en) * 2001-05-09 2002-11-20 Millenium Pharmaceuticals, Inc. 63751, Human sugar tranporter family member and uses therefor
JPWO2002101035A1 (en) * 2001-05-10 2004-09-24 持田製薬株式会社 A novel voltage-gated cation channel protein
AU2002320536A1 (en) * 2001-07-10 2003-01-29 Millennium Pharmaceuticals, Inc. 52908, a human potassium channel, and uses thereof
US20030044933A1 (en) * 2001-08-15 2003-03-06 Millennium Pharmaceuticals, Inc. 96895, a human sodium-hydrogen exchanger family member and uses therefor
WO2003038094A1 (en) * 2001-10-30 2003-05-08 Bayer Healthcare Ag Regulation of human glucose transporter
WO2003037929A1 (en) * 2001-11-01 2003-05-08 Bayer Healthcare Ag Polynucleotides encoding human potassium channel polypeptides
EP1457557A4 (en) * 2001-12-21 2005-12-28 Takeda Pharmaceutical NEW CORRESPONDING PROTEINS AND DNA
WO2003056005A1 (en) * 2001-12-27 2003-07-10 Takeda Chemical Industries, Ltd. Human sglt homolog promoter and use thereof
WO2003062274A1 (en) * 2002-01-18 2003-07-31 Takeda Chemical Industries, Ltd. Novel proteins and dnas thereof
US20050176010A1 (en) * 2002-04-16 2005-08-11 Bayer Healthcare Ag Regulation of human transient receptor potential channel
AU2003275713A1 (en) * 2002-10-29 2004-05-25 Takeda Pharmaceutical Company Limited Use of sglt homolog
WO2004081041A1 (en) * 2003-03-10 2004-09-23 Bayer Healthcare Ag Organic anion transporting (oat)-like protein ust3-like1 and uses thereof
WO2005029086A2 (en) * 2003-09-22 2005-03-31 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with organic cation transporter slc22a10 (ust3-like2) (slc22a10)
AU2010300093B2 (en) * 2009-09-25 2015-07-09 Australian Centre For Plant Functional Genomics Pty Ltd Cation channel activity
US20230357391A1 (en) * 2020-08-04 2023-11-09 Exelixis, Inc. Cd47 binding agents and uses thereof
CN115322248B (en) * 2022-05-18 2024-05-17 大连理工大学 A potassium ion channel protein AlAKT1, its encoding gene and its application

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005367A2 (en) * 1998-07-24 2000-02-03 Sagami Chemical Research Center Human proteins having hydrophobic domains and dnas encoding these proteins
WO2000026245A2 (en) * 1998-11-04 2000-05-11 Incyte Pharmaceuticals, Inc. Human membrane transport proteins
WO2000026253A1 (en) * 1998-11-03 2000-05-11 Smithkline Beecham P.L.C. Human potassium channel (h-traak)
WO2000027871A2 (en) * 1998-11-09 2000-05-18 Centre National De La Recherche Scientifique - Cnrs New family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs
WO2000052164A2 (en) * 1999-03-01 2000-09-08 Millennium Pharmaceuticals, Inc. Potassium channel molecules and uses therefor
WO2001032872A2 (en) * 1999-11-01 2001-05-10 Millennium Pharmaceuticals, Inc. Twik potassium channel molecules and uses therefor
WO2001055367A1 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005367A2 (en) * 1998-07-24 2000-02-03 Sagami Chemical Research Center Human proteins having hydrophobic domains and dnas encoding these proteins
WO2000026253A1 (en) * 1998-11-03 2000-05-11 Smithkline Beecham P.L.C. Human potassium channel (h-traak)
WO2000026245A2 (en) * 1998-11-04 2000-05-11 Incyte Pharmaceuticals, Inc. Human membrane transport proteins
WO2000027871A2 (en) * 1998-11-09 2000-05-18 Centre National De La Recherche Scientifique - Cnrs New family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs
WO2000052164A2 (en) * 1999-03-01 2000-09-08 Millennium Pharmaceuticals, Inc. Potassium channel molecules and uses therefor
WO2001032872A2 (en) * 1999-11-01 2001-05-10 Millennium Pharmaceuticals, Inc. Twik potassium channel molecules and uses therefor
WO2001055367A1 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 2 May 2001 (2001-05-02), "Homo sapiens 2P domain potassium channel Talk-2 (KCNK17) mRNA, complete cds.", XP002212647, Database accession no. AF358910 *
DATABASE EMBL [online] 23 December 1998 (1998-12-23), "CIT-HSP-2384B13.TRB CIT-HSP Homo sapiens genomic clone 2384B13, genomic survey sequence.", XP002212499, Database accession no. AQ310967 *
DATABASE EMBL [online] 7 January 2000 (2000-01-07), "Human DNA sequence from clone RP1-137F1 on chromosome 6p21.1-21.2 Contains two genes for novel members of the potassium channel subfamily K (KCNK).Contains ESTs, STSs, GSSs and a CpG island.", XP002212498, Database accession no. AL136087 *
DATABASE GENESEQ [online] 8 January 2002 (2002-01-08), "Human musculoskeletal system related polynucleotide SEQ ID NO 3748.", XP002212648, Database accession no. AAL37383 *
DATABASE GENESEQ [online] 8 January 2002 (2002-01-08), "Human musculoskeletal system related polynucleotide SEQ ID NO 881.", XP002212649, Database accession no. AAL35539 *
GIRARD C ET AL: "GENOMIC AND FUNCTIONAL CHARACTERISTICS OF NOVEL HUMAN PANCREATIC 2P DOMAIN K+ CHANNELS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 1, no. 282, 23 March 2001 (2001-03-23), pages 249 - 256, XP002908280, ISSN: 0006-291X *

Also Published As

Publication number Publication date
EP1313854A2 (en) 2003-05-28
CA2415808A1 (en) 2002-01-17
AU2001273239A1 (en) 2002-01-21
JP2004513618A (en) 2004-05-13
WO2002004520A2 (en) 2002-01-17

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