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WO2002066060A3 - Ultraschallgestützte transmembrane medikamentenapplikation in vivo - Google Patents

Ultraschallgestützte transmembrane medikamentenapplikation in vivo Download PDF

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Publication number
WO2002066060A3
WO2002066060A3 PCT/DE2002/000582 DE0200582W WO02066060A3 WO 2002066060 A3 WO2002066060 A3 WO 2002066060A3 DE 0200582 W DE0200582 W DE 0200582W WO 02066060 A3 WO02066060 A3 WO 02066060A3
Authority
WO
WIPO (PCT)
Prior art keywords
ultrasound
medicaments
transmembrane
assisted
externally
Prior art date
Application number
PCT/DE2002/000582
Other languages
English (en)
French (fr)
Other versions
WO2002066060A2 (de
Inventor
Hans-Peter Berlien
Gerhard Mueller
Carsten Philipp
Peter Urban
Original Assignee
Dornier Medtech Systems Gmbh
Hans-Peter Berlien
Gerhard Mueller
Carsten Philipp
Peter Urban
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dornier Medtech Systems Gmbh, Hans-Peter Berlien, Gerhard Mueller, Carsten Philipp, Peter Urban filed Critical Dornier Medtech Systems Gmbh
Publication of WO2002066060A2 publication Critical patent/WO2002066060A2/de
Publication of WO2002066060A3 publication Critical patent/WO2002066060A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Die Erfindung bezieht sich auf ein Verfahren und auf eine Vorrichtung zur ultraschallgestützten transmembranen Medikamentenapplikation in vivo. Zur lokal extern steuerbaren Verabreichung von Medikamenten unmittelbar in lebende Zellen, Zellcluster und damit in Gewebe soll es ermöglicht werden, zunächst durch eine getrennte Injektion die zu verarbreichenden Medikamente derart in den Körper zu bringen, dass sie wahlweise an oder innerhalb kleiner Vesikel bzw. Bläschen aggregiert sind, die sodann durch eine zusätzliche Massnahme mittels Ultraschall zur Abgabe der Medikamente an die Zellmembranen veranlasst werden. Gelöst ist diese Aufgabe im wesentlichen dadurch, dass in zwei getrennten Schritten zum einen präformierte Gasblasen, die von aussen und oder innen mit der gewünschten Wirksubstanz in innigem Kontakt stehen, in die Zielregion eingebracht werden und dass in einem zweiten Schritt anschliessend von aussen durch einen Ultraschallgeber ein Kavitationsprozess ausgelöst wird.
PCT/DE2002/000582 2001-02-19 2002-02-18 Ultraschallgestützte transmembrane medikamentenapplikation in vivo WO2002066060A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10108798.5 2001-02-19
DE2001108798 DE10108798A1 (de) 2001-02-19 2001-02-19 Verfahren und Vorrichtung zur ultraschallgestützten transmembranen Medikamentenapplikation in vivo

Publications (2)

Publication Number Publication Date
WO2002066060A2 WO2002066060A2 (de) 2002-08-29
WO2002066060A3 true WO2002066060A3 (de) 2003-02-06

Family

ID=7675272

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/000582 WO2002066060A2 (de) 2001-02-19 2002-02-18 Ultraschallgestützte transmembrane medikamentenapplikation in vivo

Country Status (2)

Country Link
DE (1) DE10108798A1 (de)
WO (1) WO2002066060A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005075700A1 (en) * 2004-02-09 2005-08-18 Paul Scherrer Institut Pulsed protection window for applications in pulsed laser deposition

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033474A1 (en) * 1996-03-12 1997-09-18 Board Of Regents Of The University Of Nebraska Targeted site specific drug delivery compositions and method of use
WO1997040679A1 (en) * 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
WO1998051284A1 (en) * 1997-05-13 1998-11-19 Imarx Pharmaceutical Corp. Novel acoustically active drug delivery systems
WO2000002588A1 (en) * 1998-07-13 2000-01-20 The Board Of Regents Of The University Of Nebraska Targeted site specific drug delivery compositions and method of use
USRE36939E (en) * 1991-03-22 2000-10-31 Ekos Corporation Composition for therapy of diseases with ultrasonic and pharmaceutical liquid composition containing the same
WO2001026704A2 (en) * 1999-10-12 2001-04-19 Yehuda Yarmut Targeted drug activation
WO2002066597A1 (de) * 2001-02-19 2002-08-29 Dornier Medtech Systems Gmbh Verfahren und vorrichtung zur ultraschallimpfung von biologischem zellmaterial

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE36939E (en) * 1991-03-22 2000-10-31 Ekos Corporation Composition for therapy of diseases with ultrasonic and pharmaceutical liquid composition containing the same
WO1997033474A1 (en) * 1996-03-12 1997-09-18 Board Of Regents Of The University Of Nebraska Targeted site specific drug delivery compositions and method of use
WO1997040679A1 (en) * 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
WO1998051284A1 (en) * 1997-05-13 1998-11-19 Imarx Pharmaceutical Corp. Novel acoustically active drug delivery systems
WO2000002588A1 (en) * 1998-07-13 2000-01-20 The Board Of Regents Of The University Of Nebraska Targeted site specific drug delivery compositions and method of use
WO2001026704A2 (en) * 1999-10-12 2001-04-19 Yehuda Yarmut Targeted drug activation
WO2002066597A1 (de) * 2001-02-19 2002-08-29 Dornier Medtech Systems Gmbh Verfahren und vorrichtung zur ultraschallimpfung von biologischem zellmaterial

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PORTER T R ET AL: "THE EFFECT OF MICROBUBBLE GAS COMPOSITION AND EXTERNAL ULTRASOUND FREQUENCY ON THE NON-INVASIVE ENHANCEMENT OF ANTISENSE OLIGONUCLEOTIDE DELIVERY TO THE VASCULAR WALL IN PIGS", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 96, no. 8, 21 October 1997 (1997-10-21), pages L - 401, XP000198974, ISSN: 0009-7322 *

Also Published As

Publication number Publication date
DE10108798A1 (de) 2002-09-26
WO2002066060A2 (de) 2002-08-29

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