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WO2002057453A3 - Polypeptides et acides nucleiques codant ces derniers - Google Patents

Polypeptides et acides nucleiques codant ces derniers Download PDF

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Publication number
WO2002057453A3
WO2002057453A3 PCT/US2001/050331 US0150331W WO02057453A3 WO 2002057453 A3 WO2002057453 A3 WO 2002057453A3 US 0150331 W US0150331 W US 0150331W WO 02057453 A3 WO02057453 A3 WO 02057453A3
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WO
WIPO (PCT)
Prior art keywords
nucleic acids
polypetides
acids encoding
encoding same
disclosed
Prior art date
Application number
PCT/US2001/050331
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English (en)
Other versions
WO2002057453A2 (fr
Inventor
Esha A Gangolli
Meera Patturajan
Corine A M Vernet
Uriel M Malyankar
Ramesh Kekuda
David J Stone
David Anderson
Richard A Shimkets
Catherine E Burgess
Bryan D Zerhusen
Xiaohong Liu
Kimberly A Spytek
Stacie J Casman
Ferenc L Boldog
Glennda Smithson
Li Li
Weizhen Ji
Original Assignee
Curagen Corp
Esha A Gangolli
Meera Patturajan
Corine A M Vernet
Uriel M Malyankar
Ramesh Kekuda
David J Stone
David Anderson
Richard A Shimkets
Catherine E Burgess
Bryan D Zerhusen
Xiaohong Liu
Kimberly A Spytek
Stacie J Casman
Ferenc L Boldog
Glennda Smithson
Li Li
Weizhen Ji
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, Esha A Gangolli, Meera Patturajan, Corine A M Vernet, Uriel M Malyankar, Ramesh Kekuda, David J Stone, David Anderson, Richard A Shimkets, Catherine E Burgess, Bryan D Zerhusen, Xiaohong Liu, Kimberly A Spytek, Stacie J Casman, Ferenc L Boldog, Glennda Smithson, Li Li, Weizhen Ji filed Critical Curagen Corp
Priority to CA002433313A priority Critical patent/CA2433313A1/fr
Priority to JP2002558505A priority patent/JP2005508601A/ja
Priority to EP01993342A priority patent/EP1352065A2/fr
Publication of WO2002057453A2 publication Critical patent/WO2002057453A2/fr
Publication of WO2002057453A3 publication Critical patent/WO2002057453A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)

Abstract

L'invention concerne des séquences d'acides nucléiques qui codent de nouveaux polypeptides. L'invention concerne également des polypeptides codés par ces séquences d'acides nucléiques, ainsi que des anticorps qui se lient de manière immunospécifique au polypeptide. L'invention concerne également des dérivés, variants, mutants ou fragments dudit polypeptide, polynucléotide ou anticorps. L'invention concerne en outre des méthodes de traitement, de diagnostic et de recherche pour diagnostiquer, traiter et prévenir des troubles dans lesquels intervient un acide nucléique quelconque ou une protéine quelconque de ces nouveaux acides nucléiques et protéines humains.
PCT/US2001/050331 2000-12-19 2001-12-19 Polypeptides et acides nucleiques codant ces derniers WO2002057453A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002433313A CA2433313A1 (fr) 2000-12-19 2001-12-19 Polypeptides et acides nucleiques codant ces derniers
JP2002558505A JP2005508601A (ja) 2000-12-19 2001-12-19 ポリペプチドおよびそれをコードする核酸
EP01993342A EP1352065A2 (fr) 2000-12-19 2001-12-19 Polypeptides et acides nucleiques codant ces derniers

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US26570400P 2000-12-19 2000-12-19
US60/256,704 2000-12-19
US25731400P 2000-12-20 2000-12-20
US60/257,314 2000-12-20
US28815301P 2001-05-02 2001-05-02
US60/288,153 2001-05-02
US29407501P 2001-05-29 2001-05-29
US60/294,075 2001-05-29
US30750601P 2001-07-24 2001-07-24
US60/307,506 2001-07-24
US31159001P 2001-08-10 2001-08-10
US31161301P 2001-08-10 2001-08-10
US60/311,590 2001-08-10
US60/311,613 2001-08-10
US31561701P 2001-08-29 2001-08-29
US60/315,617 2001-08-29
US32235801P 2001-09-14 2001-09-14
US60/322,358 2001-09-14

Publications (2)

Publication Number Publication Date
WO2002057453A2 WO2002057453A2 (fr) 2002-07-25
WO2002057453A3 true WO2002057453A3 (fr) 2003-08-14

Family

ID=27578753

Family Applications (1)

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PCT/US2001/050331 WO2002057453A2 (fr) 2000-12-19 2001-12-19 Polypeptides et acides nucleiques codant ces derniers

Country Status (3)

Country Link
JP (1) JP2005508601A (fr)
CA (1) CA2433313A1 (fr)
WO (1) WO2002057453A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008332B2 (en) 2006-05-31 2011-08-30 Takeda San Diego, Inc. Substituted indazoles as glucokinase activators
US8034822B2 (en) 2006-03-08 2011-10-11 Takeda San Diego, Inc. Glucokinase activators
US8124617B2 (en) 2005-09-01 2012-02-28 Takeda San Diego, Inc. Imidazopyridine compounds
US8163779B2 (en) 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
US9370565B2 (en) 2000-04-28 2016-06-21 The Johns Hopkins University Dendritic cell co-stimulatory molecules

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1234031T3 (en) 1999-11-30 2017-07-03 Mayo Foundation B7-H1, AN UNKNOWN IMMUNE REGULATORY MOLECULE
WO2002055704A2 (fr) * 2001-01-09 2002-07-18 Curagen Corp Proteines, polynucleotides codant pour elles et procedes d'utilisation correspondants
WO2003038094A1 (fr) * 2001-10-30 2003-05-08 Bayer Healthcare Ag Regulation du transporteur de glucose humain
US20050124793A1 (en) * 2001-12-21 2005-06-09 Takeda Chemical Industries, Ltd. Novel proteins and dnas thereof
WO2004106935A2 (fr) * 2003-05-27 2004-12-09 Bayer Healthcare Ag Agents diagnostiques et therapeutiques destines a des maladies associees au recepteur 103 couples aux proteines g (gpr103)
DK2096120T3 (da) * 2004-02-20 2012-07-09 Develogen Ag Anvendelse af sekreterede proteinprodukter til at forebygge og behandle pankreatiske sygdomme og/eller obesitet og/eller metabolsk syndrom
DK3428191T3 (da) 2004-10-06 2025-01-02 Mayo Found Medical Education & Res B7-h1 og pd-1 til behandling af renalcellekarcinom
WO2006055704A2 (fr) * 2004-11-17 2006-05-26 Curagen Corporation Anticorps diriges contre des proteines ten-m et utilisations associees
WO2006062135A1 (fr) * 2004-12-07 2006-06-15 Riken Diagnostic pour maladie mentale
WO2010052288A1 (fr) * 2008-11-07 2010-05-14 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Teneurine et cancer
US9302005B2 (en) 2013-03-14 2016-04-05 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
US10259875B2 (en) 2013-10-01 2019-04-16 Mayo Foundation For Medical Education And Research Methods for treating cancer in patients with elevated levels of BIM
US10302653B2 (en) 2014-05-22 2019-05-28 Mayo Foundation For Medical Education And Research Distinguishing antagonistic and agonistic anti B7-H1 antibodies
US10517875B2 (en) 2014-07-23 2019-12-31 Mayo Foundation for Medical Engineering and Research Targeting DNA-PKcs and B7-H1 to treat cancer
WO2017075045A2 (fr) 2015-10-30 2017-05-04 Mayo Foundation For Medical Education And Research Anticorps anti-b7-h1
US12264189B2 (en) 2018-10-31 2025-04-01 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
US12257286B2 (en) 2018-10-31 2025-03-25 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001066690A2 (fr) * 2000-03-06 2001-09-13 Smithkline Beecham Corporation Nouveaux composes
WO2001072961A2 (fr) * 2000-03-24 2001-10-04 Smithkline Beecham Corporation Nouveaux composes
WO2002046409A2 (fr) * 2000-12-06 2002-06-13 Curagen Corporation Proteines et acides nucleiques les codant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001066690A2 (fr) * 2000-03-06 2001-09-13 Smithkline Beecham Corporation Nouveaux composes
WO2001072961A2 (fr) * 2000-03-24 2001-10-04 Smithkline Beecham Corporation Nouveaux composes
WO2002046409A2 (fr) * 2000-12-06 2002-06-13 Curagen Corporation Proteines et acides nucleiques les codant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EBI; 1 October 2000 (2000-10-01), XP002223479, retrieved from EMBL Database accession no. Q9NQ36 *
GRIMMOND SEAN ET AL: "Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1).", GENOMICS, vol. 70, no. 1, 15 November 2000 (2000-11-15), pages 74 - 81, XP002223477, ISSN: 0888-7543 *
GRIMMOND SEAN ET AL: "Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development.", MECHANISMS OF DEVELOPMENT, vol. 102, no. 1-2, April 2001 (2001-04-01), pages 209 - 211, XP002223478, ISSN: 0925-4773 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9370565B2 (en) 2000-04-28 2016-06-21 The Johns Hopkins University Dendritic cell co-stimulatory molecules
US8124617B2 (en) 2005-09-01 2012-02-28 Takeda San Diego, Inc. Imidazopyridine compounds
US8034822B2 (en) 2006-03-08 2011-10-11 Takeda San Diego, Inc. Glucokinase activators
US8008332B2 (en) 2006-05-31 2011-08-30 Takeda San Diego, Inc. Substituted indazoles as glucokinase activators
US8394843B2 (en) 2006-05-31 2013-03-12 Takeda California, Inc. Substituted isoindoles as glucokinase activators
US8163779B2 (en) 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators

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Publication number Publication date
WO2002057453A2 (fr) 2002-07-25
JP2005508601A (ja) 2005-04-07
CA2433313A1 (fr) 2002-07-25

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