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WO2002050098A3 - Haplotypes of the prlr gene - Google Patents

Haplotypes of the prlr gene Download PDF

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Publication number
WO2002050098A3
WO2002050098A3 PCT/US2001/049049 US0149049W WO0250098A3 WO 2002050098 A3 WO2002050098 A3 WO 2002050098A3 US 0149049 W US0149049 W US 0149049W WO 0250098 A3 WO0250098 A3 WO 0250098A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
prlr
gene
disclosed
prlr gene
Prior art date
Application number
PCT/US2001/049049
Other languages
French (fr)
Other versions
WO2002050098A2 (en
Inventor
Karyn M Bieglecki
Amy Duda
Beena Koshy
Original Assignee
Genaissance Pharmaceuticals
Karyn M Bieglecki
Amy Duda
Beena Koshy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Karyn M Bieglecki, Amy Duda, Beena Koshy filed Critical Genaissance Pharmaceuticals
Priority to AU2002229099A priority Critical patent/AU2002229099A1/en
Publication of WO2002050098A2 publication Critical patent/WO2002050098A2/en
Publication of WO2002050098A3 publication Critical patent/WO2002050098A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel genetic variants of the Prolactin Receptor (PRLR) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the PRLR gene. Compositions and methods for haplotyping and/or genotyping the PRLR gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/049049 2000-12-18 2001-12-18 Haplotypes of the prlr gene WO2002050098A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002229099A AU2002229099A1 (en) 2000-12-18 2001-12-18 Haplotypes of the prlr gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25652300P 2000-12-18 2000-12-18
US60/256,523 2000-12-18

Publications (2)

Publication Number Publication Date
WO2002050098A2 WO2002050098A2 (en) 2002-06-27
WO2002050098A3 true WO2002050098A3 (en) 2003-03-20

Family

ID=22972544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/049049 WO2002050098A2 (en) 2000-12-18 2001-12-18 Haplotypes of the prlr gene

Country Status (2)

Country Link
AU (1) AU2002229099A1 (en)
WO (1) WO2002050098A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006235258A1 (en) * 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. Cancer-related genes
EP2129793A1 (en) * 2007-03-20 2009-12-09 Institut National De La Sante Et De La Recherche Medicale Constitutively active mutants of the prolactin receptor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GLASOW ET AL.: "Mutational analysis of the PRL receptor gene in human breast tumors with differential PRL receptor protein expression", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 86, no. 8, August 2001 (2001-08-01), pages 3826 - 3832, XP002958195 *
HU ET AL.: "The human prolactin receptor gene structure and alternative promoter utilization: the generic promoter hPIII and a novel human promoter hPN", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 84, no. 3, March 1999 (1999-03-01), pages 1153 - 1156, XP002958196 *
NICKERSON ET AL.: "Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene", GENOME RESEARCH, vol. 10, no. 10, October 2000 (2000-10-01), pages 1532 - 1545, XP002947337 *

Also Published As

Publication number Publication date
WO2002050098A2 (en) 2002-06-27
AU2002229099A1 (en) 2002-07-01

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