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WO2002044351A3 - Regulation de la coa ligase humaine d'acides gras - Google Patents

Regulation de la coa ligase humaine d'acides gras Download PDF

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Publication number
WO2002044351A3
WO2002044351A3 PCT/EP2001/013795 EP0113795W WO0244351A3 WO 2002044351 A3 WO2002044351 A3 WO 2002044351A3 EP 0113795 W EP0113795 W EP 0113795W WO 0244351 A3 WO0244351 A3 WO 0244351A3
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acid
coa ligase
acid coa
human fatty
regulation
Prior art date
Application number
PCT/EP2001/013795
Other languages
English (en)
Other versions
WO2002044351A2 (fr
Inventor
Alex Smolyar
Original Assignee
Bayer Ag
Alex Smolyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Alex Smolyar filed Critical Bayer Ag
Priority to AU2002227949A priority Critical patent/AU2002227949A1/en
Publication of WO2002044351A2 publication Critical patent/WO2002044351A2/fr
Publication of WO2002044351A3 publication Critical patent/WO2002044351A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des réactifs qui régulent la CoA ligase humaine d'acides gras et des réactifs qui se lient à des produits géniques de la CoA ligase humaine d'acides gras, ces réactifs pouvant jouer un rôle dans la prévention, l'amélioration ou la correction de maladies ou de dysfonctionnements tels que, de façon non exhaustive, des troubles du SNC, des troubles cardiovasculaires et le cancer.
PCT/EP2001/013795 2000-12-01 2001-11-27 Regulation de la coa ligase humaine d'acides gras WO2002044351A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002227949A AU2002227949A1 (en) 2000-12-01 2001-11-27 Regulation of human fatty acid coa ligase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25012300P 2000-12-01 2000-12-01
US60/250,123 2000-12-01

Publications (2)

Publication Number Publication Date
WO2002044351A2 WO2002044351A2 (fr) 2002-06-06
WO2002044351A3 true WO2002044351A3 (fr) 2002-11-21

Family

ID=22946378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013795 WO2002044351A2 (fr) 2000-12-01 2001-11-27 Regulation de la coa ligase humaine d'acides gras

Country Status (2)

Country Link
AU (1) AU2002227949A1 (fr)
WO (1) WO2002044351A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2462587A1 (fr) * 2001-12-19 2003-07-03 Exelixis, Inc. Modulation de la signalisation des recepteurs de l'insuline par ciblage de genes de facl (acyl-coa synthetase))

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
[online] EBI; 1 August 1998 (1998-08-01), "SA gene", XP002213134, retrieved from EMBL Database accession no. O60363 *
[online] EBI; 15 April 1994 (1994-04-15), "Human SA mRNA for SA gene product, acetyl-CoA synthetase homologue", XP002213135, retrieved from EMBL Database accession no. D16350 *
[online] EBI; 2 February 1995 (1995-02-02), "H. sapiens SA mRNA", XP002213136, retrieved from EMBL Database accession no. X80062 *
[online] EBI; 27 November 1998 (1998-11-27), "Mus musculus SA protein mRNA", XP002213137, retrieved from EMBL Database accession no. AF068246 *
[online] EBI; 4 June 1999 (1999-06-04), "Bos taurus mitochondrial mRNA for xenobiotic/medium chain fatty acid:CoA ligase from XL-III", XP002213138, retrieved from EMBL Database accession no. AJ132751 *
FUJINO TAKAHIRO ET AL: "Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 38, 21 September 2001 (2001-09-21), pages 35961 - 35966, XP001094129, ISSN: 0021-9258 *
IWAI NAOHARU ET AL: "Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension.", CIRCULATION, vol. 105, no. 1, January 1-8, 2002, pages 41 - 47, XP001105333, ISSN: 0009-7322 *
IWAI NAOHARU ET AL: "Human SA gene locus as a candidate locus for essential hypertension.", HYPERTENSION (DALLAS), vol. 23, no. 3, March 1994 (1994-03-01), pages 375 - 380, XP001097389, ISSN: 0194-911X *
KNIGHTS K M ET AL: "Xenobiotic-CoA ligases: Kinetic and molecular characterization.", CURRENT DRUG METABOLISM, vol. 1, no. 1, July 2000 (2000-07-01), July, 2000, pages 49 - 66, XP001105301, ISSN: 1389-2002 *
LOFTUS BRENDAN J ET AL: "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.", GENOMICS, vol. 60, no. 3, 15 September 1999 (1999-09-15), pages 295 - 308, XP002177511, ISSN: 0888-7543 *
NABIKA TORU ET AL: "Evaluation of the SA Locus in Human Hypertension.", HYPERTENSION (DALLAS), vol. 25, no. 1, 1995, pages 6 - 13, XP001104818, ISSN: 0194-911X *

Also Published As

Publication number Publication date
AU2002227949A1 (en) 2002-06-11
WO2002044351A2 (fr) 2002-06-06

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